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Project: Development and production of bispecific monovalent antibodies and immunotoxins for immunotherapy of cancer.

project duration
01-JAN-96 – 31-DEC-99
abstract
The synthesis of antibody derivatives, directed towards a tumor-antigen, is described. On the one hand, genetic fusion of the antibody fragment recognising the tumor antigen to a toxin will be carried out, and on the other hand, the synthesis of bispecific derivatives is envisaged. Both products aim at the destruction of the cancer cell, either by direct killing, or by more efficient presentation to the immune system.