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Project: Regulation of peroxisome expression.

project duration
01-JAN-97 – 31-OCT-99
abstract
Because phenotypic expression of peroxisomes is variable, regulating facors are searched for in : 1) fetal development of liver in rat and human 2) oocytes and follicle cells of quail (in vivo and in vitro), mouse, human 3) hepatocytes in culture 4) liver of peroxisomal patients. The role in differentiation of peroxisomes of extracellular factors laminin, collagen IV, cell communication through gapjunctions and adhesiomolecules, retinoic acid of nuclear PPAR and RXR receptors will be examined.