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Project: Activation and expression of NFkB in chronic lymphatic leukemia in correlation with in vitro apoptosis and clinical relevance.

01-JAN-99 – 31-OCT-02

The purpose of the study is to examine the correlation of in vitro resistance of CLL cells to therapy with clinical resistance and other prognostic factors. A relationship with the type of NFkB and the presence of constitutive active NFkB will be explored. If such a relationship is found, it will be examined if pharmacological modification of the FNkB mediated resistance is possible.