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Project: ACE and ACE inhibitory peptides in insects

01-JAN-03 – 31-OCT-08

The project investigates the presence of ACE inhibitory peptides in insect protein. Different insects (about 50 species) from different origin, orders/families and development will be screened. After enzymatic hydrolysis of the protein, active fractions are isolated by ACE affinity chromatography. During the project, an ACE affinity column is to be developed wherein ACE (angiotensin converting enzyme) is bound to an Affi-15 gel. After isolation of the active ACE-inhibitory peptides, their antihypertensive activity is evaluated by in vivo tests with rats. Also, the use of this novel target site in the conrol of pest insects will be evaluated. Finally, we will search for the existence of a simple correlation between ACE activity with the origin/habitat, development and overall proein composition (content of total proteins, collagen and myofibrillar protein) of the tested insects.