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Project: Immunolocalization of interleukin-2 receptors in inflammatory myopathies. Phenotype of inflammatory cells and expression of adhesion molecules in nodular infiltrates in inflammatory myopathies.

project duration
01-JAN-00 – 31-DEC-99
abstract
The lymphocyte activation marker interleukin-2 will be localized by dual immunofluorescence in inflammatory myopathies and compared to the activation markers ICAM-I and CD45RO. inflammatory cell phenotyping and adhesion molecule expression in nodularinfiltrates in dermatomyositis and sclerodermia will be studied. These infiltrates may show characteristics of secundary lymphoid tissues. The findings are important for the immunopathogenesis and the developm. of new therapeutic strategies.