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Project: Cellular expression of the BRCA1 protein and influence of ALP's (alkyllipofosfolipids).

1998-01-01 – 2000-12-31

Abstract

Expression of the BRCA1 protein is studied in normal breast tissue, in premalignant and in malignant breast lesions by immunehistochemistry and confocal microscopy. Clinical and genetic implications of differences in expression of this protein in patients with breast cancer will be examined. The influence of ALP's on BRCA1 expression, motility and chemotaxis will be investigated. Research will be focused on the possible role of this protein as an oncosuppressor gen.