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Project: Development of reference methods in clinical chemistry for thermolabile and high molecular mass compounds based on isotope dilution mass spectrometry coupled to liquid chromatography.

project duration
01-JAN-96 – 30-APR-01
abstract
Referende methods are essential for harmonization of analytical methods on an accuracy basis. ID/MS is generally recognized as reference methodology. But, up to now MS could only be coupled to gas chromatography. Consequently, only reference methods are available for thermostable and/or low molecular mass components. Recently, coupling of MS with liquid chromatography became possible. This means that now also the development of reference methods for the component class of thermolabile and/or high molecular mass substances is possible, which is the objective of the project.