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Project: Immune mechanisms in inflammatory myopathies.

project duration
01-JAN-97 – 31-OCT-00
abstract
T cell-mediated myocytotoxicity is an immune effector mechanism in polymyositis and inclusion body myositis. The role of macrophages is unknown. In dermatomyositis, the immune effector response is primarily directed against intramuscular endothelia. Following up on our previous studies on adhesion molecule expression, CD45 isoform distribution, and TNF-alpha and TND receptor expression, we now plan to immunolocalize (1) Fas and Fas-ligand in T cell-mediated myocytotoxicity (2) the cell surface protease CD26 (3) the different forms of nitric oxide synthase on macrophages and endothelial cells.