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Project: Effect of mouse (m)IL-10 secreting Lactococcus lactis on local and systemic immune response in animal models of inflammatory bowel diseases (IBD)

project duration
01-OCT-03 – 30-SEP-05
abstract
The study aims to characterize the intestinal mucosal and systemic changes induced by delivery of mIL-10 in mice IBD models to understand the exact mode of action of IL-10 in suppression of gut inflammation and the transmucosal way of uptake and pathway of mIL)10 secreting L. lactis. The final goal is to allow safe application of this therapeutic in patients with IBD.