prof. dr. Kris Vleminckx

Loss of function of the zinc finger homeobox 4 gene, ZFHX4, underlies a neurodevelopmental disorder

Maria del Rocio Pérez Baca (UGent) , María Palomares-Bralo, Michiel Vanhooydonck (UGent) , Lisa Hamerlinck (UGent) , Eva D'haene (UGent) , Sebastian Leimbacher (UGent) , Eva Jacobs, Laurenz De Cock (UGent) , Erika D'haenens (UGent) , Annelies Dheedene (UGent) , et al.

(2025) AMERICAN JOURNAL OF HUMAN GENETICS.

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CRISPR/Cas9 mediated disruption of an evolutionary conserved putative enhancer in the mab21l2 locus induces developmental eye anomalies in Xenopus tropicalis

Münevver Burcu Cicekdal (UGent) , Fabiola Ceroni, Richard Holt, Thomas Naert (UGent) , Soeren S. Lienkamp, Elena Sorokin, Elena Semina, Nicolas Chassaing, Nicola Ragge, Elfride De Baere (UGent) , et al.

(2024) EUROPEAN JOURNAL OF HUMAN GENETICS. In European Journal of Human Genetics 32(Supplement 1). p.247-247

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Deletion upstream of MAB21L2 highlights the importance of evolutionarily conserved non-coding sequences for eye development

Fabiola Ceroni, Münevver Burcu Cicekdal (UGent) , Richard Holt, Elena Sorokina, Nicolas Chassaing, Samuel Clokie, Thomas Naert (UGent) , Lidiya V. Talbot, Sanaa Muheisen, Dorine A. Bax, et al.

(2024) NATURE COMMUNICATIONS. 15(1).

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Evolutionary origin of Hoxc13-dependent skin appendages in amphibians

Marjolein Carron (UGent) , Attila Placido Sachslehner, Münevver Burcu Cicekdal (UGent) , Inge Bruggeman (UGent) , Suzan Demuynck (UGent) , Bahar Golabi, Elfride De Baere (UGent) , Wim Declercq (UGent) , Erwin Tschachler, Kris Vleminckx (UGent) , et al.

(2024) NATURE COMMUNICATIONS. 15(1).

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Regulation of non-canonical expression of ABCA4 by an RPE-specific enhancer with implications in ABCA4-associated disease

Victor Lopez Soriano (UGent) , Alfredo Dueñas Rey (UGent) , Giulia Ascari (UGent) , Münevver Burcu Cicekdal (UGent) , Eva D'haene (UGent) , Quinten Mahieu (UGent) , Hanna De Saffel (UGent) , Andy Willaert (UGent) , Kris Vleminckx (UGent) , Juan Jesus Tena-Aguilar, et al.

(2024) EUROPEAN JOURNAL OF HUMAN GENETICS. In European Journal of Human Genetics 32(Supplement 1). p.39-40

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Dual molecular effects of constitutional SF3B2 variants cause a novel dominant spliceosomopathy displaying retinitis pigmentosa or developmental skeletal anomalies

Stijn Van de Sompele (UGent) , Caroline Van Cauwenbergh (UGent) , Marjolein Carron (UGent) , Alfredo Dueñas Rey (UGent) , Frauke Coppieters (UGent) , Toon Rosseel (UGent) , Hong Tran, Robrecht Cannoodt (UGent) , Thalia Van Laethem (UGent) , Brecht Guillemyn (UGent) , et al.

(2023) EUROPEAN JOURNAL OF HUMAN GENETICS. In European Journal of Human Genetics 31(Supplement 1). p.71-71

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Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis

Dieter Tulkens, Marthe Boelens (UGent) , Thomas Naert (UGent) , Marjolein Carron (UGent) , Suzan Demuynck (UGent) , Sylviane Dewaele (UGent) , Gert Van Isterdael (UGent) , David Creytens (UGent) , Tim Pieters (UGent) , Steven Goossens (UGent) , et al.

(2023) LEUKEMIA. 37. p.2404-2413

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Multi-omics approach dissects cis-regulatory mechanisms underlying North Carolina macular dystrophy, a retinal enhanceropathy

Stijn Van de Sompele (UGent) , Kent W. Small, Münevver Burcu Cicekdal (UGent) , Victor Lopez Soriano (UGent) , Eva D'haene (UGent) , Fadi S. Shaya, Steven Agemy, Thijs Van der Snickt (UGent) , Alfredo Dueñas Rey (UGent) , Toon Rosseel (UGent) , et al.

(2022) AMERICAN JOURNAL OF HUMAN GENETICS. 109(11). p.2029-2048

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Identifying and characterizing EZH2 as a druggable dependency factor for desmoid tumors in a genetic Xenopus tropicalis model for Gardner's Syndrome

Thomas Naert (UGent) , Dieter Tulkens, Tom Van Nieuwenhuysen (UGent) , Joanna Przybyl, Suzan Demuynck (UGent) , Mushriq Al-Jazrawe, Matt van de Rijn, Benjamin Alman, Kim De Leenheer, Paul Coucke (UGent) , et al.

(2022) EUROPEAN JOURNAL OF HUMAN GENETICS. 30(SUPPL 1). p.71-72

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Engraftment of allotransplanted tumor cells in adult rag2 mutant Xenopus tropicalis

Dieter Tulkens, Dionysia Dimitrakopoulou, Marthe Boelens (UGent) , Tom Van Nieuwenhuysen (UGent) , Suzan Demuynck (UGent) , Wendy Toussaint (UGent) , David Creytens (UGent) , Pieter Van Vlierberghe (UGent) and Kris Vleminckx (UGent)

(2022) CANCERS. 14(19).

Academic Bibliography

prof. dr. Kris Vleminckx

Loss of function of the zinc finger homeobox 4 gene, ZFHX4, underlies a neurodevelopmental disorder

CRISPR/Cas9 mediated disruption of an evolutionary conserved putative enhancer in the mab21l2 locus induces developmental eye anomalies in Xenopus tropicalis

Deletion upstream of MAB21L2 highlights the importance of evolutionarily conserved non-coding sequences for eye development

Evolutionary origin of Hoxc13-dependent skin appendages in amphibians

Regulation of non-canonical expression of ABCA4 by an RPE-specific enhancer with implications in ABCA4-associated disease

Dual molecular effects of constitutional SF3B2 variants cause a novel dominant spliceosomopathy displaying retinitis pigmentosa or developmental skeletal anomalies

Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis

Multi-omics approach dissects cis-regulatory mechanisms underlying North Carolina macular dystrophy, a retinal enhanceropathy

Identifying and characterizing EZH2 as a druggable dependency factor for desmoid tumors in a genetic Xenopus tropicalis model for Gardner's Syndrome

Engraftment of allotransplanted tumor cells in adult rag2 mutant Xenopus tropicalis

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