prof. dr. apr. Niek Sanders
- ORCID iD
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0000-0003-4585-0343
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Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo
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Transcriptomic heterogeneity of nine complementary mouse TNBC models based on their comparative in vitro and in vivo characterization
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- Journal Article
- A1
- open access
A f entanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity
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- Journal Article
- A1
- open access
CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity
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- Journal Article
- A1
- open access
Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation
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- Journal Article
- A1
- open access
Less is more : self-amplifying mRNA becomes self-killing upon dose escalation in immune-competent retinal cells
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- Journal Article
- A1
- open access
PH-triggered, lymph node focused immunodrug release by polymeric 2-propionic-3-methyl-maleic anhydrides with cholesteryl end groups
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- Journal Article
- A1
- open access
Immunogenicity and biodistribution of lipid nanoparticle formulated self-amplifying mRNA vaccines against H5 avian influenza
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- Journal Article
- A1
- open access
Combinatorial screening of biscarbamate ionizable lipids identifies a low reactogenicity lipid for lipid nanoparticle mRNA delivery
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Chitin-mediated blockade of chitinase-like proteins reduces tumor growth and immunosuppression in a mouse model for TNBC