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M2e-tetramer-specific memory CD4 T cells are broadly protective against influenza infection
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Oral delivery of Escherichia coli persistently infected with M2e-displaying bacteriophages partially protects against influenza A virus
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Bispecific T cell engaging antibody constructs targeting a universally conserved part of the viral M2 ectodomain cure and prevent influenza A virus infection
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M2-based influenza vaccines : recent advances and clinical potential
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- Journal Article
- A1
- open access
Long-lasting cross-protection against influenza A by neuraminidase and M2e-based immunization strategies
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Crystal structure of the conserved amino terminus of the extracellular domain of matrix protein 2 of influenza A virus gripped by an antibody
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Comparison of the antiviral activity of Mus spretus Mx1 and Mus musculus A2G Mx1 against influenza A viruses
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- Journal Article
- A2
- open access
M2e-based universal influenza A vaccines
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Functional comparison of Mx1 from two different mouse species reveals the involvement of loop L4 in the antiviral activity against influenza A viruses
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- Journal Article
- A1
- open access
Protection against influenza A virus challenge with M2e-displaying filamentous Escherichia coli phages
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- Journal Article
- A1
- open access
A GFP expressing influenza A virus to report in vivo tropism and protection by a matrix protein 2 ectodomain-specific monoclonal antibody
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Structure of the extracellular domain of matrix protein 2 of influenza A virus in complex with a protective monoclonal antibody
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- Journal Article
- A1
- open access
Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein
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Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge
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Natural and long-lasting cellular immune responses against influenza in the M2e-immune host
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- Journal Article
- A1
- open access
Immunogenicity of live attenuated B. pertussis BPZE1 producing the universal influenza vaccine candidate M2e
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- Journal Article
- A1
- open access
M2e-displaying virus-like particles with associated RNA promote T helper 1 type adaptive immunity against influenza A
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Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice
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Cutting edge approaches towards novel and cross-protective influenza vaccines
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Interferon-inducible protein Mx1 inhibits influenza virus by interfering with functional viral ribonucleoprotein complex assembly
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Cytokine research in Belgium
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A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus
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Universal vaccine based on ectodomain of matrix protein 2 of Influenza A: Fc receptors and alveolar macrophages mediate protection
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- Journal Article
- A1
- open access
Antiserum against the conserved nine amino acid N-terminal peptide of influenza A virus matrix protein 2 is not immunoprotective
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- Journal Article
- A1
- open access
Controlling influenza by cytotoxic T-cells : calling for help from destroyers
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Cloning and expression of human interferon-beta: from bc to ac
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M2e-based universal influenza A vaccine
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Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments
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PANDEMIC PREPAREDNESS: TOWARD A UNIVERSAL INFLUENZA VACCINE
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Universal influenza A M2e-HBc vaccine protects against disease even in the presence of pre-existing anti-HBc antibodies
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An influenza A vaccine based on tetrameric ectodomain of matrix protein 2
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CTA1-M2e-DD: A novel mucosal adjuvant targeted influenza vaccine
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- Journal Article
- A3
- open access
A universal vaccine against influenza
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Improved design and intranasal delivery of an M2e-based human influenza A vaccine
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Improved periplasmic production of biologically active murine interleukin-2 in Escherichia coli through a single amino acid change at the cleavage site
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The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection
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Universal influenza A vaccine: Optimization of M2-based constructs
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A "universal" human influenza A vaccine
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Tumor necrosis factor-alpha augmented tumor response in B16BL6 melanoma-bearing mice treated with stealth liposomal doxorubicin (DOXIL (R)) correlates with altered DOXIL (R) pharmacokinetics
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Characterization of the interaction between murine tumour necrosis factor and monoclonal antibodies.
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Bioavailability of recombinant tumor necrosis factor determines its lethality in mice.
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Spontaneous and oncogene-mediated acquisition of the invasive phenotype by cells in culture.
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Soluble recombinant influenza vaccines
(2001) PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES. 356(1416). p.1961-1963 -
Kanker: wat brengt de toekomst?
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Heterotrimers formed by tumor necrosis factors of different species or muteins.
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Identification of tumor necrosis factor (TNF) amino acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants.
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Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria.
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Expression in Escherichia coli of the death domain of the human p55 tumor necrosis factor receptor.
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Role of reactive oxygen species in tumor necrosis factor toxicity
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Structure/function analysis of p55 tumor necrosis factor receptor and Fas-associated death domain : effect on necrosis in L929sA cells.
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Cloning and expression of cytokine genes
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Protection against TNF-induced lethal shock by soluble guanylate cyclase inhibition requires functional inducible nitric oxide synthase.
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Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential.
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Fab chains as an efficient heterodimerization scaffold for the production of recombinant bispecific and trispecific antibody derivatives.
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Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.
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Tumor necrosis factor-induced microtubule stabilization mediated by hyperphosphorylated oncoprotein 18 promotes cell death.
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Redox regulation of TNF signaling.
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Proteolytic cleavage of beta-catenin by caspases: an in vitro analysis.
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The proteolytic procaspase activation network: an in vitro analysis.
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More than one way to die: apoptosis, necrosis and reactive oxygen damage.
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An advanced vector system for high-level recombinant gene expression in Escherichia coli
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GAL4 is a substrate for caspases : implications for two-hybrid screening and other GAL4-based assays
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The structure of mouse tumour-necrosis factor at 1.4 angstrom resolution: towards modulation of its selectivity and trimerization.
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The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.
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Identification of a locus on distal mouse chromosome 12 that controls resistance to tumor necrosis factor-induced lethal shock.
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A universal influenza A vaccine based on the extracellular domain of the M2 protein.
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Inhibition of Tumor Necrosis Factor-induced necrotic cell death by the zinc finger protein A20.
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- Journal Article
- A1
- open access
The zinc finger protein A20 inhibits TNF-induced NF-kappa B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappa B-inhibiting protein ABIN.
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The role of complement activation in tumour necrosis factor-induced lethal hepatitis.
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Protection of mice against a lethal influenza virus challenge after immunization with yeast-derived secreted influenza virus hemagglutinin.
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Identification of caspases that cleave presenilin-1 and presenilin-2 - Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases.
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Multiple signal transduction pathways regulate TNF-induced actin reorganization in macrophages: Inhibition of Cdc42-mediated filopodium formation by TNF.
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The 55-kDa tumor necrosis factor receptor induces clustering of mitochondria through its membrane-proximal region.
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Tumor necrosis factor and lymphotoxin
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Engineering of the carbohydrate moiety of fungal proteins to a mammalian type
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Identification of a new caspase homologue: caspase-14.
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Cathepsin B-mediated activation of the proinflammatory caspase-11
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Quiescence-inducing and antiapoptotic activities of IL-15 enhance secondary CD4(+) T cell responsiveness to antigen.
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- Journal Article
- A1
- open access
Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.
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Cooperation of both TNF receptors in inducing apoptosis: Involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75.
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Molecular cloning and identification of murine caspase-8.
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An antibody which binds to the membrane-proximal end of influenza virus haemagglutinin (H3 subtype) inhibits the low-pH-induced conformational change and cell-cell fusion but does not neutralize virus.
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Cross-talk between steroids and NF-kappa B: what language?
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Use of the yeast three-hybrid system as a tool to study caspases.
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Differentiation of EL4 lymphoma cells by tumoral environment is associated with inappropriate expression of the large chondroitin sulfate proteoglycan PG-M and the tumor-associated antigen HTgp-175.
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Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity.
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TRAF2 plays a dual role in NF-kappa B-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and I kappa B kinase pathways.
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- Journal Article
- A1
- open access
Dual signaling of the Fas receptor: Initiation of both apoptotic and necrotic cell death pathways.
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Macrophages induce cellular immunity by activating Th1 cell responses and suppressing Th2 cell responses.
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Differential activation of phospholipases during necrosis or apoptosis: A comparative study using tumor necrosis factor and anti-Fas antibodies.
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Evaluation of recombinant A/Victoria/3/75 (H3N2) influenza neuraminidase mutants as potential broad-spectrum subunit vaccines against influenza A.
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Cloning and expression of a fused gene encoding TNFRI death domain and chloramphenicol acetyltransferase.
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Regulation of microsomal triglyceride transfer protein mRNA expression by endotoxin and cytokines.
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Functional display of a heterologous protein on the surface of Lactococcus lactis by means of the cell wall anchor of Staphylococcus aureus protein A
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pH-dependent aggregation and secretion of soluble monomeric influenza hemagglutinin.
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- Journal Article
- A1
- open access
Autocrine tumor necrosis factor (TNF) and lymphotoxin (LT) alpha differentially modulate cellular sensitivity to TNF/LT-alpha cytotoxicity in L929 cells.
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Induction of unresponsiveness to tumor necrosis factor (TNF) after autocrine TNF expression requires TNF membrane retention.
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p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor kappa B p65 transactivation mediated by tumor necrosis factor.
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Efficient secretion of biologically active recombinant OB protein (leptin) in Escherichia coli, purification from the periplasm and characterization.
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High-level constitutive expression of alpha(1)-acid glycoprotein and lack of protection against tumor necrosis factor-induced lethal shock in transgenic mice.