Emily De Lombaerde

Journal Article
A1
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Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo

Yong Chen (UGent) , Emily De Lombaerde, Aimee-Rose Bugler-Lamb (UGent) , Zifu Zhong (UGent) , Martijn Schuijs (UGent) , Claudia Mariela Brenis Gómez (UGent) , Jamie De Baere (UGent) , Mark Gontsarik (UGent) , Heleen Lauwers (UGent) , Kim Deswarte (UGent) , et al.

(2025) ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 64(28).

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CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

Tingting Ye, Zifu Zhong (UGent) , Federica Cappellesso, Kim Deswarte (UGent) , Yong Chen (UGent) , Heleen Lauwers (UGent) , Emily De Lombaerde, Mark Gontsarik (UGent) , Stefan Lienenklaus, Dorien Van Lysebetten, et al.

(2024) BIOMATERIALS. 311.

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Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation

Emily De Lombaerde, Xiaole Cui (UGent) , Yong Chen (UGent) , Zifu Zhong (UGent) , Julie Deckers (UGent) , Giulia Mencarelli, Lisa Opsomer (UGent) , Haixiu Wang, Jamie De Baere (UGent) , Stefan Lienenklaus, et al.

(2024) ACS NANO. 18(41). p.28311-28324

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Combinatorial screening of biscarbamate ionizable lipids identifies a low reactogenicity lipid for lipid nanoparticle mRNA delivery

Emily De Lombaerde, Yong Chen (UGent) , Tingting Ye, Julie Deckers (UGent) , Giulia Mencarelli, Kim Deswarte (UGent) , Heleen Lauwers (UGent) , Ruben De Coen (UGent) , Sabah Kasmi (UGent) , Sanne Bevers, et al.

(2024) ADVANCED FUNCTIONAL MATERIALS. 34(21). p.1-16

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Lipid nanoparticle encapsulation empowers poly(I:C) to activate cytoplasmic RLRs and thereby increases its adjuvanticity

Alexander Lamoot, Sonia Jangra, Gabriel Laghlali, Prajakta Warang, Gagandeep Singh, Lauren A. Chang, Seok‐Chan Park, Gagandeep Singh, Kim Deswarte (UGent) , Zifu Zhong (UGent) , et al.

(2024) SMALL. 20(10).

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Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids

Alexander Lamoot, Joris Lammens (UGent) , Emily De Lombaerde, Zifu Zhong (UGent) , Mark Gontsarik (UGent) , Yong Chen (UGent) , Thomas De Beer (UGent) and Bruno De Geest (UGent)

(2023) BIOMATERIALS SCIENCE. 11(12). p.4327-4334

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Lipid nanoparticle delivery alters the adjuvanticity of the TLR9 agonist CpG by innate immune activation in lymphoid tissue

Zifu Zhong (UGent) , Yong Chen (UGent) , Kim Deswarte (UGent) , Heleen Lauwers (UGent) , Emily De Lombaerde, Xiaole Cui (UGent) , Simon Van Herck (UGent) , Tingting Ye, Mark Gontsarik (UGent) , Stefan Lienenklaus, et al.

(2023) ADVANCED HEALTHCARE MATERIALS. 12(32).

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PhD Thesis

Synthesis and evaluation of ionizable lipids for lipid nanoparticle mediated RNA delivery

Emily De Lombaerde

(2023)

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Delivery routes matter : safety and efficacy of intratumoral immunotherapy

Emily De Lombaerde, Olivier De Wever (UGent) and Bruno De Geest (UGent)

(2021) BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. 1875(2).

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Emily De Lombaerde

Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo

CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation

Combinatorial screening of biscarbamate ionizable lipids identifies a low reactogenicity lipid for lipid nanoparticle mRNA delivery

Lipid nanoparticle encapsulation empowers poly(I:C) to activate cytoplasmic RLRs and thereby increases its adjuvanticity

Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids

Lipid nanoparticle delivery alters the adjuvanticity of the TLR9 agonist CpG by innate immune activation in lymphoid tissue

Synthesis and evaluation of ionizable lipids for lipid nanoparticle mediated RNA delivery

Delivery routes matter : safety and efficacy of intratumoral immunotherapy

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