dr. Yong Chen

Multivalent antibody-recruiters targeting fibroblast activation protein for innate immune killing

Weiwei Mu (UGent) , Yong Chen (UGent) , Zifu Zhong (UGent) , Jamie De Baere (UGent) , Heleen Lauwers (UGent) , Demi Defreyne (UGent) , Haixia Peng, Bruno De Geest (UGent) and Benoit Louage (UGent)

(2026) BIOMACROMOLECULES. 27(6). p.4026-4037

Add to list

Admixing of mRNA with pre‐formed lipid nanoparticles containing a slightly‐cationic ionizable lipid allows for efficient mRNA transfection in vitro and in vivo

Haixiu Wang, Heleen Lauwers (UGent) , Mark Gontsarik (UGent) , Yong Chen (UGent) , Niek Sanders (UGent) , Miffy Hok Yan Cheng, Bruno De Geest (UGent) and Zifu Zhong (UGent)

(2025) ADVANCED HEALTHCARE MATERIALS. 14(23).

Add to list

Journal Article
A1
open access

Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo

Yong Chen (UGent) , Emily De Lombaerde, Aimee-Rose Bugler-Lamb (UGent) , Zifu Zhong (UGent) , Martijn Schuijs (UGent) , Claudia Mariela Brenis Gómez (UGent) , Jamie De Baere (UGent) , Mark Gontsarik (UGent) , Heleen Lauwers (UGent) , Kim Deswarte (UGent) , et al.

(2025) ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 64(28).

Add to list

Journal Article
A1
open access

A fentanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity

Zifu Zhong (UGent) , Marie Deventer (UGent) , Yong Chen (UGent) , Stijn Vanhee (UGent) , Inés Lammens (UGent) , Kim Deswarte (UGent) , Yi Huang (UGent) , Tingting Ye, Haixiu Wang, Lutz Nuhn (UGent) , et al.

(2025) ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 64(7).

Add to list

Journal Article
A2
open access

Exploration of solid phase peptoid synthesis for the design of trifunctional hapten-lipid-TLR7/8 agonist antibody-recruiting oligomers that combine innate effector with innate activation function

Haixia Peng, Steven Martens (UGent) , Annemiek Uvyn (UGent) , Yong Chen (UGent) , Zifu Zhong (UGent) , Benoit Louage (UGent) and Bruno De Geest (UGent)

(2024) ACS APPLIED BIO MATERIALS. 8(1). p.177-188

Add to list

Journal Article
A1
open access

Galloyl dialkyl lipids drive encapsulation of peptides into lipid nanoparticles by hydrogen bonding

Tingting Ye, Yong Chen (UGent) , Zifu Zhong (UGent) , Yi Huang (UGent) , Jamie De Baere (UGent) , Mark Gontsarik (UGent) , Kim Deswarte (UGent) , Bianka Golba, Martijn Risseeuw (UGent) , Serge Van Calenbergh (UGent) , et al.

(2024) JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 147(1). p.1307-1318

Add to list

Journal Article
A1
open access

HER2 nanobody-poly(rhamnose) conjugates efficiently recruit anti-rhamnose antibodies from serum to the surface of HER2-expressing cells

Weiwei Mu (UGent) , Yong Chen (UGent) , Zifu Zhong (UGent) , Benoit Louage (UGent) , Heleen Lauwers (UGent) , Nick Devoogdt, Jurgen Haustraete (UGent) and Bruno De Geest (UGent)

(2024) CHEMISTRY OF MATERIALS. 36(20). p.10113-10124

Add to list

Journal Article
A1
open access

CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

Tingting Ye, Zifu Zhong (UGent) , Federica Cappellesso, Kim Deswarte (UGent) , Yong Chen (UGent) , Heleen Lauwers (UGent) , Emily De Lombaerde, Mark Gontsarik (UGent) , Stefan Lienenklaus, Dorien Van Lysebetten, et al.

(2024) BIOMATERIALS. 311.

Add to list

Journal Article
A1
open access

Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation

Emily De Lombaerde, Xiaole Cui (UGent) , Yong Chen (UGent) , Zifu Zhong (UGent) , Julie Deckers (UGent) , Giulia Mencarelli, Lisa Opsomer (UGent) , Haixiu Wang, Jamie De Baere (UGent) , Stefan Lienenklaus, et al.

(2024) ACS NANO. 18(41). p.28311-28324

Add to list

Journal Article
A1
open access

Lysosomal trafficking and degradation of extracellular proteins via multivalent small molecule ligand display on dextran scaffolds

Benoit Louage (UGent) , Demi Defreyne (UGent) , Heleen Lauwers (UGent) , Jamie De Baere (UGent) , Annemiek Uvyn (UGent) , Haixia Peng, Yong Chen (UGent) and Bruno De Geest (UGent)

(2024) BIOMACROMOLECULES. 26(1). p.738-750

Academic Bibliography

dr. Yong Chen

Multivalent antibody-recruiters targeting fibroblast activation protein for innate immune killing

Admixing of mRNA with pre‐formed lipid nanoparticles containing a slightly‐cationic ionizable lipid allows for efficient mRNA transfection in vitro and in vivo

Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo

A fentanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity

Exploration of solid phase peptoid synthesis for the design of trifunctional hapten-lipid-TLR7/8 agonist antibody-recruiting oligomers that combine innate effector with innate activation function

Galloyl dialkyl lipids drive encapsulation of peptides into lipid nanoparticles by hydrogen bonding

HER2 nanobody-poly(rhamnose) conjugates efficiently recruit anti-rhamnose antibodies from serum to the surface of HER2-expressing cells

CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation

Lysosomal trafficking and degradation of extracellular proteins via multivalent small molecule ligand display on dextran scaffolds

Contents

Support

Contact