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Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23
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- Journal Article
- A1
- open access
Ym1 protein crystals promote type 2 immunity
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- Journal Article
- A1
- open access
Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2
(2024) EMBO JOURNAL. -
- Journal Article
- A1
- open access
Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice
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- Journal Article
- A1
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Mechanism of receptor assembly via the pleiotropic adipokine Leptin
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- Journal Article
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Rare antagonistic leptin variants and severe, early-onset obesity
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- Journal Article
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Improving de novo protein binder design with deep learning
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- Journal Article
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Unexpected complexity of the ammonia monooxygenase in archaea
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- Journal Article
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EGOC inhibits TOROID polymerization by structurally activating TORC1
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- Journal Article
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Pore-forming proteins as drivers of membrane permeabilization in cell death pathways
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- Journal Article
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The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement
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- Journal Article
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Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27
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- Journal Article
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The Charcot-Leyden crystal protein Galectin-10 is not a major determinant of human regulatory T-cell function
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- Journal Article
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Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity
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- Journal Article
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Design of protein-binding proteins from the target structure alone
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- Journal Article
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The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice
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- Journal Article
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Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding
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- Journal Article
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Natural antibodies : protecting role of IgM in glioblastoma and brain tumours
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- Journal Article
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Rational design and development of HDAC inhibitors for breast cancer treatment
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- Journal Article
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Hapin1b, a central organizer of the ECM, modulates kit signaling to control developmental hematopoiesis in zebrafish
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A recombinant antibody fragment directed to the thymic stromal lymphopoietin receptor (CRLF2) efficiently targets pediatric Philadelphia chromosome-like acute lymphoblastic leukemia
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- Journal Article
- A1
- open access
Structural basis of cytokine-mediated activation of ALK family receptors
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Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors
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CRISPR-SID : identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping
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Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase
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- Journal Article
- A1
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Minimal epitope for Mannitou IgM on paucimannose-carrying glycoproteins.
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- Journal Article
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Engineering and crystal structure of a monomeric FLT3 ligand variant
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Charcot-Leyden crystals and other protein crystals driving type 2 immunity and allergy
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- Journal Article
- A1
- open access
Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding
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- Journal Article
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Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting
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- Journal Article
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Attenuated CSF-1R signalling drives cerebrovascular pathology
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- Journal Article
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Molecular architecture of the endocytic TPLATE complex
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- Journal Article
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- open access
Homogeneously N-glycosylated proteins derived from the GlycoDelete HEK293 cell line enable diffraction-quality crystallogenesis
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Structure and assembly mechanism of the signaling complex mediated by human CSF-1 (vol 23, pg 1621, 2015)
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- Journal Article
- A1
- open access
Mouse strain-dependent difference toward the staphylococcus aureus allergen serine protease-like protein D reveals a novel regulator of IL-33
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- Journal Article
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Modulation of signaling mediated by TSLP and IL-7 in inflammation, autoimmune diseases, and cancer
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- Journal Article
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DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance
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- Journal Article
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Single-chain soluble receptor fusion proteins as versatile cytokine inhibitors
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- Journal Article
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Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents
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Small-molecule inhibitors get pro-inflammatory TNF into shape
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Charcot-Leyden crystals promote neutrophilic inflammation in patients with nasal polyposis
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Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms
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Revisiting the combinatorial potential of cytokine subunits in the IL-12 family
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- Journal Article
- A1
- open access
IL-33trap is a novel IL-33-neutralizing biologic that inhibits allergic airway inflammation
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Protein crystallization promotes type 2 immunity and is reversible by antibody treatment
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Pathophysiology and inhibition of IL-23 signaling in psoriatic arthritis : a molecular insight
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Disruption of endocytosis through chemical inhibition of clathrin heavy chain function
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Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle
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- Journal Article
- A1
- open access
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
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- Journal Article
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Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis
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- Journal Article
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- open access
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha
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Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells
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Nonselective chemical inhibition of Sec7 domain-containing ARF GTPase exchange factors
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- Journal Article
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Structure and oligomerization of the periplasmic domain of GspL from the type II secretion system of Pseudomonas aeruginosa
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- Journal Article
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A CARD9 founder mutation disrupts NF-κB signaling by inhibiting BCL10 and MALT1 recruitment and signalosome formation
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Structure guided lead generation toward nonchiral M. tuberculosis thymidylate kinase inhibitors
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- Journal Article
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Sensory-neuropathy-causing mutations in ATL3 cause aberrant ER membrane tethering
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Structural activation of pro-inflammatory human cytokine IL-23 by cognate IL-23 receptor enables recruitment of the shared receptor IL-12Rβ1
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Structural dissection of Shewanella oneidensis old yellow enzyme 4 bound to a Meisenheimer complex and (nitro)phenolic ligands
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- Journal Article
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Virtual screening for inhibitors of the human TSLP:TSLPR interaction
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Membrane vesicle secretion and prophage induction in multidrug-resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress
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Alzheimer's-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions
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- Journal Article
- A1
- open access
Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma
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Mechanisms of immunomodulation by mammalian and viral decoy receptors : insights from structures
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Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10
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- Journal Article
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- open access
Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF
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The design and synthesis of inhibitors of Mycobacterium tuberculosis thymidylate kinase (MtTMPK)
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Structure and assembly mechanism of the signaling complex mediated by human CSF-1
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Characterization of a type D1A EUL-related lectin from rice expressed in Pichia pastoris
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- Journal Article
- A1
- open access
Structural basis of IL-23 antagonism by an Alphabody protein scaffold
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- Journal Article
- A1
- open access
The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence
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20 Years of leptin: insights into signaling assemblies of the leptin receptor
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- Journal Article
- A1
- open access
MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates
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Structural and mechanistic paradigm of leptin receptor activation revealed by complexes with wild-type and antagonist leptins
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Structural basis of the proinflammatory signaling complex mediated by TSLP
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Molecular and structural basis of glutathione import in Gram-positive bacteria via GshT and the cystine ABC importer TcyBC of Streptococcus mutans
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Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor
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Structural and biochemical characterization of an atypical short-chain dehydrogenase/reductase reveals an unusual cofactor preference
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New insights into the assembly of bacterial secretins: structural studies of the periplasmic domain of XcpQ from Pseudomonas aeruginosa
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Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases
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Crystallization of an atypical short-chain dehydrogenase from Vibrio vulnificus lacking the conserved catalytic tetrad
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Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1
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- Conference Paper
- C3
- open access
An REMD and QM/MM study into the sequence effect on asparagine deamidation
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Glutathione biosynthesis in bacteria by bifunctional GshF is driven by a modular structure featuring a novel hybrid ATP-grasp fold
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Profiling the biofilm secretome of Burkholderia cenocpepacia in a context of type two secretion system
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Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles
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- Journal Article
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- open access
Delineation of the Pasteurellaceae-specific GbpA-family of glutathione-binding proteins
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Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex
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- Conference Paper
- C3
- open access
Peptide deamidation : effect of neighboring residues
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Inducible production of recombinant human Flt3 ectodomain variants in mammalian cells and preliminary crystallographic analysis of Flt3 ligand-receptor complexes
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Hydrophobic surface patches on LolA of Pseudomonas aeruginosa are essential for lipoprotein binding
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- Journal Article
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Towards structural studies of the old yellow enzyme homologue SYE4 from Shewanella oneidensis and its complexes at atomic resolution
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Crystallization and X-ray diffraction studies of inverting trehalose phosphorylase from Thermoanaerobacter sp.
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Glutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpA
(2010) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107(30). p.13270-13275 -
Construction of cellobiose phosphorylase variants with broadened acceptor specificity towards anomerically substituted glucosides
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The 285 kDa Bap/RTX hybrid cell surface protein (SO4317) of Shewanella oneidensis MR-1 is a key mediator of biofilm formation
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- Journal Article
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Development and application of a screening assay for glycoside phosphorylases
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- Journal Article
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Crystallization and X-ray diffraction studies of cellobiose phosphorylase from Cellulomonas uda
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Efficient production of bioactive recombinant human Flt3 ligand in E. coli
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The agglutination protein AggA from Shewanella oneidensis MR-1 is a TolC-like protein and forms active channels in vitro
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Related lectins from snowdrop and maize differ in their carbohydrate-binding specificity.
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Myristoylated adenylate kinase-2 of Plasmodium falciparum forms a heterodimer with myristoyltransferase
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Catalytic cycle of human glutathione reductase near 1 Å resolution
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Expression, purification, crystallization and structure determination of two glutathione S-transferase-like proteins from Shewanella oneidensis
(2008) ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 64(Part 6). p.548-553 -
Structural insights into component SoxY of the thiosulfate-oxidizing multienzyme system of Chlorobaculum thiosulfatiphilum
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Towards a better understanding of extracellular cytokine receptor biology: the initial characterization of a lectin/R complex
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The "Old'' Euonymus europaeus agglutinin represents a novel family of ubiquitous plant proteins
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Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase
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Secretion superfamily ATPases swing big
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Understanding nicotinamide dinucleotide cofactor and substrate specificity in class I flavoprotein disulfide oxidoreductases: Crystallographic analysis of a glutathione amide reductase
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X-ray crystallographic analysis of the sulfur carrier protein SoxY from Chlorobium limicola f. thiosulfatophilum reveals a tetrameric structure
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Structural role of tyrosine 98 in photoactive yellow protein: Effects on fluorescence, gateway, and photocycle recovery
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Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding
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- Journal Article
- A1
- open access
Crystallization, preliminary crystallographic analysis and phasing of the thiosulfate-binding protein SoxY from Chlorobium limicola f. thiosulfatophilum
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Structural and mutagenesis studies on the cytochrome c peroxidase from Rhodobacter capsulatus provide new insights into structure-function relationships of bacterial di-heme peroxidases
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Structure of a membrane-based steric chaperone in complex with its lipase substrate
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Oligosaccharide binding in family 8 glycosidases: Crystal structures of active-site mutants of the beta-1,4-xylanase pXyl from Pseudoaltermonas haloplanktis TAH3a in complex with substrate and product
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Study of the active site residues of a glycoside hydrolase family 8 xylanase
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Structure of hemocyanin subunit CaeSS2 of the crustacean Mediterranean crab Carcinus aestuarii
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Expression, purification, crystallization and preliminary crystallographic analysis of a stand-alone RAM domain with hydrolytic activity from the hyperthermophile Pyrococcus furiosus
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Expression, purification, crystallization and preliminary X-ray crystallographic studies of a cold-adapted aspartate carbamoyltransferase from Moritella profunda
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Getting the most out of a trip to the synchrotron: Structure of a putative bacterial dehalogenase
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The C-terminal domain of full-length E-coli SSB is disordered even when bound to DNA
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The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket
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Crystal structure of the thrombin mutant D221A/D222K: the Asp222: Arg187 ion-pair stabilizes the fast form
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VirB11 ATPases are dynamic hexameric assemblies: new insights into bacterial type IV secretion
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Glutathione reductase of the malarial parasite Plasmodium falciparum: Crystal structure and inhibitor development
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Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite
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Crystal structure of the anticoagulant slow form of thrombin
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Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots
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Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system
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Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers
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Kinetics and crystallographic analysis of human glutathione reductase in complex with a xanthene inhibitor
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Charge is the major discriminating factor for glutathione reductase versus trypanothione reductase inhibitors
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OVEREXPRESSION OF CRITHIDIA-FASCICULATA TRYPANOTHIONE REDUCTASE AND CRYSTALLIZATION USING A NOVEL GEOMETRY
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KUKOAMINE-A AND OTHER HYDROPHOBIC ACYLPOLYAMINES - POTENT AND SELECTIVE INHIBITORS OF CRITHIDIA-FASCICULATA TRYPANOTHIONE REDUCTASE