prof. dr. Michel Struys
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- Journal Article
- A1
- open access
Urinary biomarkers in a living donor kidney transplantation cohort : predictive value on graft function
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- Journal Article
- A1
- open access
General purpose models for intravenous anesthetics, the next generation for target-controlled infusion and total intravenous anesthesia?
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- Conference Paper
- C3
- open access
Feasibility of a Bayesian based advisory tool for target-controlled infusion of propofol using qCON as control variable
(2023) Euroanaesthesia 2023 : the European Anaesthesiology Congress, Abstracts programme. In European Journal of Anaesthesiology 40(Supplement 61). p.7-7 -
Frontal electroencephalogram based drug, sex, and age independent sedation level prediction using non-linear machine learning algorithms
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- Journal Article
- A1
- open access
Bayesian statistics in anesthesia practice : a tutorial for anesthesiologists
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Dexmedetomidine clearance decreases with increasing drug exposure : implications for current dosing regimens and target-controlled infusion models assuming linear pharmacokinetics
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- Journal Article
- A1
- open access
Machine learning in anesthesiology : detecting adverse events in clinical practice
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- Journal Article
- A1
- open access
What's new in intravenous anaesthesia? New hypnotics, new models and new applications
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Immune modulatory effects of nonsteroidal anti-inflammatory drugs in the perioperative period and their consequence on postoperative outcome
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- Journal Article
- A1
- open access
Mechanism-based pharmacodynamic model for propofol haemodynamic effects in healthy volunteers
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- Journal Article
- A1
- open access
General purpose pharmacokinetic-pharmacodynamic models for target-controlled infusion of anaesthetic drugs : a narrative review
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Uncertainty minimization and feasibility study for managing the complex and interacting anesthesia-hemodynamic system
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Allometric scaling in pharmacokinetic studies in anesthesiology
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Clinical validation of pharmacokinetic/pharmacodynamic models for propofol infusion : response to Br J Anaesth 2021 : 126 : e172-4
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- Journal Article
- A1
- open access
Perioperative SARS-CoV-2 infections increase mortality, pulmonary complications, and thromboembolic events : a Dutch, multicenter, matched-cohort clinical study
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- Journal Article
- A1
- open access
Population pharmacodynamic modeling using the sigmoid E-max model : influence of inter-individual variability on the steepness of the concentration-effect relationship : a simulation study
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Modeling the effect of excitation on depth of anesthesia monitoring in gamma-aminobutyric acid type A receptor agonist ABP-700
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Resisting neural inertia : an exercise in floccinaucinihilipilification?
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- Journal Article
- A1
- open access
Prospective clinical validation of the Eleveld propofol pharmacokinetic-pharmacodynamic model in general anaesthesia
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Modeling the effect of excitation on depth of anesthesia monitoring in gamma-aminobutyric acid type A receptor agonist ABP-700 (vol 134, pg 35, 2021)
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- Journal Article
- A1
- open access
Comparison of haemodynamic- and electroencephalographic-monitored effects evoked by four combinations of effect-site concentrations of propofol and remifentanil, yielding a predicted tolerance to laryngoscopy of 90%
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Propofol-based anaesthesia versus sevoflurane-based anaesthesia for living donor kidney transplantation : results of the VAPOR-1 randomized controlled trial (vol 118, pg 720, 2017)
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- Journal Article
- A1
- open access
Dexmedetomidine-induced deep sedation mimics non-rapid eye movement stage 3 sleep : large-scale validation using machine learning
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- Journal Article
- A1
- open access
Etomidate and its analogs : a review of pharmacokinetics and pharmacodynamics
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Environmental footprint of anesthesia : more than inhaled anesthetics!
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- Miscellaneous
- open access
Comment on Morse et al. A universal pharmacokinetic model for dexmedetomidine in children and adults
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- Journal Article
- A1
- open access
Inhaled anesthetics : environmental role, occupational risk, and clinical use
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Influence of an "electroencephalogram-based" monitor choice on the delay between the predicted propofol effect-site concentration and the measured drug effect
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Sevoflurane, a sigh of relief in COVID-19?
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The role of pharmacokinetics and pharmacodynamics in clinical anaesthesia practice
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Ten years of the Helsinki Declaration on patient safety in anaesthesiology : an expert opinion on peri-operative safety aspects
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Effects of propofol and dexmedetomidine with and without remifentanil on serum cytokine concentrations in healthy volunteers : a post hoc analysis
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Meta-analysis of ketamine pharmacokinetics : lots of work done but still lots to do
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Target-controlled-infusion models for remifentanil dosing consistent with approved recommendations
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Autonomous systems in anesthesia : where do we stand in 2020? A narrative review
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Predicting deep hypnotic state from sleep brain rhythms using deep learning : a data-repurposing approach
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Influence of remifentanil on the control performance of the bispectral index controlled Bayesian-based closed-loop system for propofol administration
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- Journal Article
- A1
- open access
Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair
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Moderate-to-deep sedation using target-controlled infusions of propofol and remifentanil : adverse events and risk factors : a retrospective cohort study of 2937 procedures
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- Journal Article
- A1
- open access
Driving pressure during general anesthesia for open abdominal surgery (DESIGNATION) : study protocol of a randomized clinical trial
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Intranasal dexmedetomidine in elderly subjects with or without beta blockade : a randomised double-blind single-ascending-dose cohort study.
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Target-controlled infusion of cefepime in critically Ill patients
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Population pharmacodynamics of propofol and sevoflurane in healthy volunteers using a clinical score and the patient state index : a crossover study
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Pharmacodynamic interaction of remifentanil and dexmedetomidine on depth of sedation and tolerance of laryngoscopy
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- Journal Article
- A1
- open access
Intraoperative fluid restriction is associated with functional delayed graft function in living donor kidney transplantation : a retrospective cohort analysis
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Novel drug-independent sedation level estimation based on machine learning of quantitative frontal electroencephalogram features in healthy volunteers
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- Journal Article
- A1
- open access
A comparison of propofol-to-BIS post-operative intensive care sedation by means of target controlled infusion, Bayesian-based and predictive control methods : an observational, open-label pilot study
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Oxygen reserve index : validation of a new variable
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Corrigendum to ‘Do we need inhaled anaesthetics toblunt arousal, haemodynamic responses tointubation after i.v. induction with propofol,remifentanil, rocuronium?’ [Br J Anaesth 2006; 97:835-841]
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Collateral ventilation measurement using chartis procedural sedation vs general anesthesia
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Opioids : refining the perioperative role of God's own medicine
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- Journal Article
- A1
- open access
Vancomycin pharmacokinetics throughout life : results from a pooled population analysis and evaluation of current dosing recommendations
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Pharmacokinetic pharmacodynamic perspective on the detection of signs of neural inertia in humans
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- Journal Article
- A1
- open access
Preemptively and non-preemptively transplanted patients show a comparable hypercoagulable state prior to kidney transplantation compared to living kidney donors
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Safety and clinical effect of i.v. infusion of cyclopropyl-methoxycarbonyl etomidate (ABP-700), a soft analogue of etomidate, in healthy subjects
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Pharmacokinetic-pharmacodynamic model for propofol for broad application in anaesthesia and sedation
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Test of neural inertia in humans during general anaesthesia
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- Journal Article
- A1
- open access
Brain changes due to hypoxia during light anaesthesia can be prevented by deepening anaesthesia : a study in rats
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European Society of Anaesthesiology and European Board of Anaesthesiology guidelines for procedural sedation and analgesia in adults
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Drug selection for ambulatory procedural sedation
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- Journal Article
- A1
- open access
Clinical pharmacokinetics and pharmacodynamics of propofol
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- Journal Article
- A1
- open access
Target-controlled continuous infusion for antibiotic dosing : proof-of-principle in an in-silico vancomycin trial in intensive care unit patients
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- Journal Article
- A1
- open access
Phenylephrine increases cardiac output by raising cardiac preload in patients with anesthesia induced hypotension
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Influence of Bayesian optimization on the performance of propofol target-controlled infusion
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Dexmedetomidine pharmacokineticpharmacodynamic modelling in healthy volunteers, 1 : influence of arousal on bispectral index and sedation
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Dexmedetomidine pharmacodynamics in healthy volunteers, 2 : haemodynamic profile
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A phase 1, single-center, double-blind, placebo-controlled study in healthy subjects to assess the safety, tolerability, clinical effects, and pharmacokinetics-pharmacodynamics of intravenous cyclopropyl-methoxycarbonylmetomidate (ABP-700) after a single ascending bolus dose
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Pharmacokinetics and pharmacodynamics of propofol : changes in patients with frontal brain tumours
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An allometric model of remifentanil pharmacokinetics and pharmacodynamics
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Propofol-based anaesthesia versus sevoflurane-based anaesthesia for living donor kidney transplantation : results of the VAPOR-1 randomized controlled trial
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Tracking electroencephalographic changes using distributions of linear models : application to propofol-vased depth of anesthesia monitoring
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Predictive performance of eleven pharmacokinetic models for propofol infusion in children for long-duration anaesthesia
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- Journal Article
- A1
- open access
Clinical pharmacokinetics and pharmacodynamics of dexmedetomidine
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- Journal Article
- A1
- open access
Patient safety during procedural sedation using capnography monitoring : a systematic review and meta-analysis
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Pharmacokinetic and pharmacodynamic interactions in anaesthesia : a review of current knowledge and how it can be used to optimize anaesthetic drug administration
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Prophylactic atropine administration attenuates the negative haemodynamic effects of induction of anaesthesia with propofol and high-dose remifentanil : a randomised controlled trial
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Acute and life-threatening remifentanil overdose resulting from the misuse of a syringe pump
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Probability to tolerate laryngoscopy and noxious stimulation response index as general indicators of the anaesthetic potency of sevoflurane, propofol, and remifentanil
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Comparisons of electroencephalographically derived measures of hypnosis and antinociception in response to standardized stimuli during target-controlled propofol-remifentanil anesthesia
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The safety of target-controlled infusions
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Performance of the Eleveld pharmacokinetic model to titrate propofol in an obese Japanese patient population
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Model-based drug administration: current status of target-controlled infusion and closed-loop control
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Propofol breath monitoring as a potential tool to improve the prediction of intraoperative plasma concentrations
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Neural mass model-based tracking of anesthetic brain states
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The history of target-controlled infusion
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Target-controlled infusion: a mature technology
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Comparisons of electroencephalographically derived measures of hypnosis and antinociception during propofol-remifentanil anesthesia
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- Journal Article
- A1
- open access
Noninvasive pulse pressure variation and stroke volume variation to predict fluid responsiveness at multiple thresholds : a prospective observational study
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Differential effects of phenylephrine and norepinephrine on peripheral tissue oxygenation during general anaesthesia: a randomised controlled trial
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A new pharmacokinetic model of propofol: effect of age on clearance and impact of the terminal distribution phase: response
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Nonlinear dynamics of the patient's response to drug effect during general anesthesia
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Comparison of continuous non-invasive finger arterial pressure monitoring with conventional intermittent automated arm arterial pressure measurement in patients under general anaesthesia
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- Journal Article
- A2
- open access
Hemodynamics and tissue oxygenation during balanced anesthesia with a high antinociceptive contribution : an observational study
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- Journal Article
- A1
- open access
A response surface model approach for continuous measures of hypnotic and analgesic effect during sevoflurane-remifentanil interaction: quantifying the pharmacodynamic shift evoked by stimulation
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Bispectral index values and propofol concentrations at loss and return of consciousness in patients with frontal brain tumours and control patients
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Accuracy of the composite variability index as a measure of the balance between nociception and, antinociception during anesthesia
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A general purpose pharmacokinetic model for propofol
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- Journal Article
- A1
- open access
Moxifloxacin dosing in post-bariatric surgery patients
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Comparison of arterial pressure and plethysmographic waveform-based dynamic preload variables in assessing fluid responsiveness and dynamic arterial tone in patients undergoing major hepatic resection
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Interaction between nitrous oxide, sevoflurane, and opioids: a response surface approach