ereprof. dr. Eric Achten
- ORCID iD
- 0000-0002-5148-4178
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- Journal Article
- A1
- open access
Developing blood-brain barrier arterial spin labelling as a non-invasive early biomarker of Alzheimer's disease (DEBBIE-AD) : a prospective observational multicohort study protocol
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- Journal Article
- A1
- open access
Effect of acetylcholinesterase inhibitors on cerebral perfusion and cognition : a systematic review
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Investigation of technical variability in ASL data using MR phantoms
(2023) MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE. In Magnetic Resonance Materials in Physics, Biology and Medicine 36(S1-S328). p.S221-S222 -
The impact of a Siemens scanner upgrade from 3 T trio tim to 3 T prisma fit on the variability of volumetric measurements based on phantom and human data
(2023) MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE. In Magnetic Resonance Materials in Physics, Biology and Medicine 36(S1-S328). p.S285-S287 -
- Journal Article
- A1
- open access
Current state and guidance on arterial spin labeling perfusion MRI in clinical neuroimaging
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- Journal Article
- A1
- open access
Imaging blood-brain barrier dysfunction : a state-of-the-art review from a clinical perspective
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The impact of a Siemens scanner upgrade from 3T Trio Tim to 3T Prisma Fit on the variability of volumetric measurements based on phantom and human data
(2023) -
Application of frozen Thiel-embalmed specimens for radiotherapy delineation guideline development : a method to create accurate MRI-enhanced CT datasets
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- Journal Article
- A1
- open access
Characterizing scatter correction software of 5 mobile radiography units : an anthropomorphic phantom study
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- Journal Article
- A1
- open access
Evaluation of virtual grid processed clinical chest radiographs
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- Journal Article
- A1
- open access
The impact of accelerated HF-rTMS on canine brain metabolism : an [18F]-FDG PET study in healthy beagles
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- Journal Article
- A1
- open access
ASL-BIDS, the brain imaging data structure extension for arterial spin labeling
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ASL-BIDS Example Datasets
(2022) -
Perfusion imaging : a biomarker for treatment response in Alzheimer’s disease?
(2022) JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. In Journal of Cerebral Blood Flow and Metabolism 42(supplement 1). p.91-92 -
- Miscellaneous
- open access
ASL-BIDS, the brain imaging data structure extension for arterial spin labeling
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- Journal Article
- A1
- open access
The costs and benefits of estimating T-1 of tissue alongside cerebral blood flow and arterial transit time in pseudo-continuous arterial spin labeling
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- Journal Article
- A1
- open access
Supporting measurements or more averages? How to quantify cerebral blood flow most reliably in 5 minutes by arterial spin labeling
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- Journal Article
- A1
- open access
Impact of a code stroke protocol on the door-to-needle time for IV thrombolysis : a feasibility study
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Impact of software parameter settings on image quality of virtual grid processed radiography images : a contrast-detail phantom study
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- Journal Article
- A1
- open access
Modeling brain dynamics after tumor resection using The Virtual Brain
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- Journal Article
- A1
- open access
ExploreASL : an image processing pipeline for multi-center ASL perfusion MRI studies
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- Journal Article
- A2
- open access
SCSA based MATLAB pre-processing toolbox for 1H MR spectroscopic water suppression and denoising
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The use of Thiel embalmed human cadavers for retrograde injection and visualization of the lymphatic system
(2020) ANATOMICAL RECORD - ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY. 303(9). p.2392-2401 -
- Journal Article
- A1
- open access
Optimization of PET protocol and interrater reliability of 18F-PSMA-11 imaging of prostate cancer
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- Journal Article
- A1
- open access
A new class of smart gadolinium contrast agent for tissue pH probing using magnetic resonance imaging
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Radiation dosimetry and biodistribution of 18F-PSMA-11 for PET imaging of prostate cancer
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- Journal Article
- A1
- open access
Residual water suppression using the squared eigenfunctions of the Schrödinger operator
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Matlab tool for residual water suppression and denoising of MRS signal using the Schrodinger operator
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Semi-classical signal analysis method with soft-thresholding for MRS denoising
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A multi-site round robin assessment of ASL using a perfusion phantom
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A joint coordinate system for biomechanical analysis of the sacroiliac joint
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TVB time series and connectomes for personalized brain modeling in brain tumor patients
(2019) -
- Journal Article
- A1
- open access
Modeling brain dynamics in brain tumor patients using the virtual brain
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Multi-center reproducibility of structural, diffusion tensor, and resting state functional magnetic resonance imaging measures
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Targeting phosphocreatine metabolism in relapsing-remitting multiple sclerosis : evaluation with brain MRI, 1H and 31P MRS, and clinical and cognitive testing
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- Journal Article
- A1
- open access
Reduction of acquisition time using partition of the signal decay in spectroscopic imaging technique (RAPID-SI)
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- Conference Paper
- P1
- open access
Automated assessment of bone age using deep learning and Gaussian process regression
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- Journal Article
- A1
- open access
Variability of physiological brain perfusion in healthy subjects : a systematic review of modifiers : considerations for multi-center ASL studies
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Reduction of Acquisition time by Partition of the signal Decay in Spectroscopic Imaging (RAPID-SI) technique: Preliminary in-vivo results and comparison with CSI.
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Reduction of Acquisition time by Partition of the signal Decay in Spectroscopic Imaging (RAPID-SI) technique : preliminary In-vivo results and comparison with CSI
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- Journal Article
- A1
- open access
'Unforgettable' : a pictorial essay on anatomy and pathology of the hippocampus
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- Journal Article
- A1
- open access
Proximal aortic stiffening in Turner patients may be present before dilation can be detected : a segmental functional MRI study
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Effects of histidine and β-alanine supplementation on human muscle carnosine storage
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Evaluation of automatic image quality assessment in chest CT : a human cadaver study
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Reduction of Acquisition time by Partition of the signal Decay in Spectroscopic Imaging (RAPID-SI) technique : simulation results on a 2D application
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Cyclic movement frequency is associated with muscle typology in athletes
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Reduction of Acquisition time by Partition of the signal Decay in Spectroscopic Imaging (RAPID-SI) technique : a new approach for high speed spectroscopic imaging
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Brachial plexus 3D reconstruction from MRI with dissection validation : a baseline study for clinical applications
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- Journal Article
- A1
- open access
Optimal number of atlases and label fusion for automatic multi-atlas-based brachial plexus contouring in radiotherapy treatment planning
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The role of Size-Specific Dose Estimate (SSDE) in patient-specific organ dose and cancer risk estimation in paediatric chest and abdominopelvic CT examinations
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Magnetic resonance imaging de-noising using the squared eigenfunctions of the Schrödinger operator : application to brain MRI data
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Using Tc-99m-HMPAO SPECT as tool to compare two transcranial magnetic stimulation protocols and their long-term effects in dogs
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Proximal aortic stiffening in Turner patients is more pronounced in the presence of a bicuspid valve : a segmental functional MRI study
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The better the distance runner, the more slow-twitch muscle typology?
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- Conference Paper
- C3
- open access
Modeling brain activity in brain tumor patients and healthy controls: a proof-of-concept study
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- Journal Article
- A1
- open access
The effect of morphometric atlas selection on multi-atlas-based automatic brachial plexus segmentation
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- Journal Article
- A2
- open access
Exercise training and beta-alanine-induced muscle carnosine loading
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Organ doses and radiation risk of computed tomographic coronary angiography in a clinical patient population: how do low-dose acquisition modes compare?
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In vivo quantification of the [11C]-DASB binding in the normal canine brain using Positron Emission Tomography
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- Journal Article
- A1
- open access
The vulnerability to suicidal behavior is associated with reduced connectivity strength
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- Journal Article
- A1
- open access
In vivo quantification of the [11C]DASB binding in the normal canine brain using positron emission tomography
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- Journal Article
- A1
- open access
Correlation of clinical and physical-technical image quality in chest CT : a human cadaver study applied on iterative reconstruction
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Magnetic resonance spectroscopy data de-noising using semi-classical signal analysis approach: application to in-vitro MRS data
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- Journal Article
- A1
- open access
Dysfunctional modulation of default mode network activity in attention-deficit/hyperactivity disorder
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MR pulse wave velocity increases with age faster in the thoracic aorta than in the abdominal aorta
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Evaluation of a Cerebral-Blood-Volume (CBV) pharmaco-MRI (phMRI) assay utilizing low (0.1mg/70kg) and high (0.2mg/70kg) dose buprenorphine infusion and a novel USPIO contrast agent (Ferumoxytol) in healthy human subjects
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- Journal Article
- A1
- open access
A neuroradiologist's guide to arterial spin labeling MRI in clinical practice
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- Journal Article
- A1
- open access
Anticipatory processes in brain state switching : evidence from a novel cued-switching task implicating default mode and salience networks
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Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells
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- Journal Article
- A1
- open access
Overlapping neural systems represent cognitive effort and reward anticipation
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The beta-alanine dose for maintaining moderately elevated muscle carnosine levels
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Muscle carnosine loading by beta-alanine supplementation is more pronounced in trained vs. untrained muscles
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Review of confounding effects on perfusion measurements
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A decade of experience with deep brain stimulation for patients with refractory medial temporal lobe epilepsy
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Lumbar muscle dysfunction during remission of unilateral recurrent nonspecific low-back pain: evaluation with muscle functional MRI
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Picture novelty attenuates semantic interference and modulates concomitant neural activity in the anterior cingulate cortex and the locus coeruleus
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Meal and beta-alanine co-ingestion enhances muscle carnosine loading
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Praxis and language are linked: evidence from co-lateralization in individuals, with atypical language dominance
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Optimizing communication between the radiologist and the general practitioner
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Structural and metabolic features of two different variants of multiple sclerosis : a PET/MRI study
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F-18 FDG PET, MRI or combined PET/MRI reading, which method is best for discriminating high-grade from low-grade gliomas?
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An anatomically validated brachial plexus contouring method for intensity modulated radiation therapy planning
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Quantifying hemodynamic refractory BOLD effects in normal subjects at the single-subject level using an inverse logit fitting procedure
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Age-related differences in metabolites in the posterior cingulate cortex and hippocampus of normal ageing brain: a 1H-MRS study
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- Journal Article
- A1
- open access
Magnetic resonance spectroscopy in migraine: what have we learned so far?
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Late-onset post-irradiation vasculopathy of the posterior cerebral vasculature
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The influence of sex, age and heritability on human skeletal muscle carnosine content
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Reduced muscle carnosine content in type 2, but not in type 1
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Real travelled aortic path length for PWV is not substantially different between left and right measurement locations
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Influence of perspective on the neural correlates of motor resonance during natural action observation
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Cerebral lateralization of praxis in right- and left-handedness: same pattern, different strength
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Altered default-mode network activation in mild cognitive impairment compared with healthy aging
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Progressive multifocal leukoencephalopathy (PML) mimicking high-grade glioma on delayed F-18 FDG PET imaging
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Carotid to femoral pulse wave velocity: a comparison of real travelled aortic path lengths determined by MRI and superficial measurements
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Absence of haemodynamic refractory effects in patients with migraine without aura : an interictal fMRI study
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Neural correlates of pantomiming familiar and unfamiliar tools: action semantics versus mechanical problem solving?
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Variability of CT contrast enhancement in the pancreas : a cause for concern?
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Carotid-femoral pulse wave velocity: age adjusted distance estimation
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Presurgical evaluation using functional connectivity resting state fMRI
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Age-related differences in metabolites in the posterior cingulate cortex and hippocampus of normal ageing brain: A 1H-MRS study
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Proton magnetic resonance spectroscopy during photic stimulation in patients with migraine without aura
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Age-related differences in metabolites in the posterior cingulate cortex and hippocampus of normal ageing brain: a 1H-MRS study
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Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humans
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- Journal Article
- A1
- open access
Mental rotation meets the motion aftereffect: the role of hV5/MT+ in visual mental imagery
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Brain energy metabolism in migraine without aura investigated by 31P- and 1H-MRS
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Carotid to femoral pulse wave velocity: a comparison of travelled aortic path lengths determined by MRI and superficial measurements
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- Journal Article
- A1
- open access
Does visual cortex lactate increase following photic stimulation in migraine without aura patients?: a functional 1H-MRS study
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Effects of sprint training combined with vegetarian or mixed diet on muscle carnosine content and buffering capacity
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- Journal Article
- A1
- open access
31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients
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- Journal Article
- A1
- open access
A new method for non-invasive estimation of human muscle fiber type composition
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Detection of resting-state brain activity in magnetic resonance images through wavelet feature cluster analysis
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Hippocampal activation during face-name associative memory encoding: blocked versus permuted design
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Proton magnetic resonance spectroscopy in Alzheimer's disease, a review
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Use of muscle functional magnetic resonance imaging to compare cervical flexor activity between patients with whiplash-associated disorders and people who are healthy
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A magnetic resonance imaging investigation into the function of the deep cervical flexors during the performance of craniocervical flexion
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Decreased energy metabolism in patients with migraine without aura: a 31P-MRS study
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Differentiation between deep and superficial fibers of the lumbar multifidus by magnetic resonance imaging
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Fitting interictal hemodynamic response functions to characterize anomalous refractory effects in patients with migraine without aura
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Important role of muscle carnosine in rowing performance
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1H-MRS of brain metabolites in migraine without aura: absolute quantification using the phantom replacement technique
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Interictal anomalies in patients with migraine without aura: absence of hemodynamic refractory effects
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Multifocal intraparietal activation during discrimination of action intention in observed tool grasping
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Distance estimation for pulse wave velocity: choosing the right method
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Carotid to femoral pulse wave velocity: which distance, obtained by tape measure, corresponds best with the real travelled aortic path lenght?
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Comparison of aortic path lengths determined by MRI and tape measure
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Neurovascular dishabituation in patients with migraine without aura
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Reduction of high-energy phosphates in the occipital lobe of migraine without aura patients : a 31P- and 1H-MRS study
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- Conference Paper
- C3
- open access
Tool use-responsive regions and tool object-responsive regions in the inferior parietal lobule are not identical : effect of differences in motor goal and target object during imagined transitive movements
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Pulse wave velocity: how to assess the distance?
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Acquired stuttering with differential manifestation in different languages: A case study
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MRI analysis of muscle/fat index of the superficial and deep neck muscles in an asymptomatic cohort
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Carnosine loading and washout in human skeletal muscles
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Absolute quantification of metabolites in migraine patients: a 1H MRS study
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Hemodynamic refractory effects in healthy volunteers and patients with migraine without aura
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Preoperative fMRI in tumour surgery
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Transverse diffusivity of cerebral parenchyma predicts visual tracking performance in relapsing-remitting multiple sclerosis
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Tool responsive regions in the posterior parietal cortex : effect of differences in motor goal and target object during imagined transitive movements
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Detecting hemodynamic refractory effects in patients with migraine without aura
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Absolute quantification of phosphorous magnetic resonance spectroscopy in migraine without aura
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Absolute quantification of proton magnetic resonance spectroscopy in migraine without aura
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Intracavitary irradiation of cystic craniopharyngioma by stereotactic instillation of beta-emitting radioisotope (yttrium 90)
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Embryology, anatomy and pathology of the pituitary gland and perisellar region: MR imaging features
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MR imaging features of spinal dysraphism : a pictoral review
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1H MRS as evaluation tool of the effects of beta-alanine supplementation on the muscle carnosine content in soleus and gastrocnemius of 400m sprinters
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- Conference Paper
- C1
- open access
Single-subject hemodynamic refractory effects in healthy volunteers
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The use of functional MRI to evaluate cervical flexor activity during different cervical flexion exercises
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Simulation and experimental verification of the diffusion in an anisotropic fiber phantom
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The role of surface relaxivity and magnetic susceptibility in the design of anisotropic fiber phantoms
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Changes in lumbar muscle activity because of induced muscle pain evaluated by muscle functional magnetic resonance imaging
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Callosal function in MS patients with mild and severe callosal damage as reflected by diffusion tensor imaging
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The design of anisotropic diffusion phantoms for the validation of diffusion weighted magnetic resonance imaging
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Structural magnetic resonance imaging in epilepsy
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Diffusion weighted callosal integrity reflects interhemispheric communication efficiency in multiple sclerosis
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Health technology assessment on the use of magnetic resonance imaging (MRI) and computed tomography (CT) in the diagnosis of multiple sclerosis (MS) and clinically isolated syndromes (CIS)
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MR imaging features of malformations of cortical development: a pictorial review
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- Conference Paper
- C1
- open access
Image Aquisition Order and Input Order of BOLD-fMRI Data for Slice Time Correction in fMRI Data Processing Tools
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Absolute quantification of carnosine in human calf muscle by proton magnetic resonance spectroscopy
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PAQAP: a quality assessment protocol for MRI
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A comparison of blocked versus mixed design in the face-name association task
(2007) NeuroImage. -
Where mental rotation meets the motion after effect: the role of hMT+/V5 in imagined transformations
(2007) NeuroImage. -
Simulation of the diffusion in the interstitial space of a fiber phantom
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Postprocessing of brain white matter fiber orientation distribution functions
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Quantitative proton magnetic resonance spectroscopy in presence of sidebands
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Absolute quantification of carnosine in human calf muscle by proton magnetic resonance spectroscopy
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Quantitative proton magnetic resonance spectroscopy without water suppression
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Simulation and experimental verification of the diffusion in the interstitial space
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A systematic comparison of absolute quantification schemes for proton magnetic resonance spectroscopy in presence of standing waves
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Quantifying the diffusion in an anisotropic fiber phantom
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Absolute quantification of carnosine in human calf muscle by proton magnetic resonance spectroscopy
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Comparison between functional magnetic resonance imaging at 1.5 and 3 tesla - Effect of increased field strength on 4 paradigms used during presurgical work-up
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beta-alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters
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Cerebral haemorraghe due to intracranial invasion of infantile haemagioma of the neck in a neonate
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Bilateral hypothalamic activation in SUNCT : a second case
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Phantom design for diffusion tensor magnetic resonance imaging
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A single measurement-based method for absolute quantification of metabolites by proton magnetic resonance spectroscopy
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Quantitative Validation of White Matter Fiber Tractography by use of an Anatomically Realistic Synthetic Diffusion Tensor Phantom
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Phantom optimization for diffusion tensor magnetic resonance imaging
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Modelling the diffusion in the interstital space of a fiber phantom
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Correlation and regularization of white matter fiber orientation distribution functions
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Applicability of the face-name associative encoding task to elicit anterior hippocampal activation in normal subjects: a pilot study
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Encoding and recognition of novel faces in the continuous face recognition task: an fMRI study
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Intracranial video-EEG monitoring at Ghent University Hospital
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Comparison between 1 T MRI and non-MRI based volumetry in inoculated tumours in mice
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Initial results of a hardware diffusion head phantom
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Single Measurement-Based Absolute Quantification of Metabolites by Proton Magnetic Resonance Spectroscopy
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Absolute metabolite quantification by proton magnetic resonance spectroscopy: preliminary results
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Density Regularized Fiber Tractography of the Brain White Matter using Diffusion Tensor MRI
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A flexible hardware phantom for validation of diffusion imaging sequences
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Amygdalohippocampal deep brain stimulation (AH-DBS) for refractory temporal lobe epilepsy
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Small animal positron emission tomography during vagus nerve stimulation in rats: A pilot study
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Stimulus pacing affects the activation of the medial temporal lobe during a semantic classification task: An fMRI study
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Trial pacing in mental rotation tasks
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Magnetic resonance angiography of the circle of Willis in migraine patients
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- Journal Article
- A1
- open access
Lateralized anterior mesiotemporal lobe activation: Semirandom functional MR imaging encoding paradigm in patients with temporal lobe epilepsy-initial experience
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Tertiary epilepsy care in Belgium: The practice at Ghent University Hospital Reference Centre for Refractory Epilepsy
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Amygdalohippocampal deep brain stimulation for refractory temporal lobe epilepsy
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Vagus nerve stimulation for refractory epilepsy: a transatlantic experience
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Cardiale kernspintomografie (NMR) bij de evaluatie van de tetralogie van Fallot
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The mechanism of action of vagus nerve stimulation
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Lessons for neuropsychology from functional MRI in patients with epilepsy
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Validation and application of polymer gel dosimetry for the dose verification of an intensity-modulated arc therapy (IMAT) treatment
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Does egocentric mental rotation elicit sex differences?
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MRI language dominance assessment in epilepsy patients at 1.0 T: region of interest analysis and comparison with intracarotid amytal testing
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MRI images of the anatomy of the axillary and supraclavicular region in treatment position for the adjuvant radiation treatment of breast cancer
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Imaging of microglial activation with PET and atrophy with MRI in multiple sclerosis : interrelationship and clinical correlates
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PET visualization of microglia in multiple sclerosis patients using [C-11]PK11195
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Amygdalohippocampal deep brain stimulation for refractory temporal lobe epilepsy
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Diepe hersenstimulatie van de mediaal temporale kwab bij patiënten met refractaire epilepsie
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Anterior mesiotemporal and hippocampal activity in healthy subjects and temporal lobe epilepsy patients detected with a variable block length fMRI paradigm
(2003) NeuroImage. -
Sex differences in mental rotation of graspable stimuli: an fMRI study
(2003) NeuroImage. -
Does handedness influence motor imagery in mental rotation? An fMRI study
(2003) NeuroImage. -
The effect of stimulus pacing on cortical activation patterns during a mental rotation paradigm: an fMRI study
(2003) NeuroImage. -
Self pacing of a semantic decision task produces better lateralization indexes and induces novelty encoding by the left mesial temporal structures: an fMRI study
(2003) NeuroImage. -
Object naming in mother tongue versus non-native languages in multilinguals reveals different patterns of lateralizaton: an fMRI study
(2003) NeuroImage. -
Assessment of neuroinflammation and microglial activation in Alzheimer’s disease with radiolabelled PK11195 and single photon emission computed tomography : a pilot study
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Neurostimulatie voor refractaire epilepsie
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Hemangioma of the left cheek: A case report
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Multilingualism: an fMRI study
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Neurostimulation for refractory epilepsy
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A pure sensorimotor stroke due to cervical vertebral artery occlusion
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Value of the quantity and distribution of subarachnoid haemorrhage on CT in the localization of a ruptured cerebral aneurysm - Comment
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Functional MRI of language and memory activation redistribution in post-operative temporal lobe epilepsy patients
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Usefulness of language and memory testing during intracarotid amobarbital testing: observations from an fMRI study
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IMAT treatment verification with monomer/polymer gel dosimetry
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fMRI of developmental stuttering: A pilot study
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Individual anterior mesiotemporal lobe FMRI activation in healthy volunteers and temporal lobe epilepsy patients using a semi-random encoding paradigm
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Application of monomer/polymer gel dosimetry to study the effects of tissue inhomogeneities on intensity-modulated radiation therapy (IMRT) dose distributions
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An unusual cause of stroke with right sensorimotor hemisyndrome
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An unusual cause of stroke with right sensorimotor hemisyndrome
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Digitale beeldenstorm: medische beeldvorming: beter, sterker, sneller
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Semiquantification of the peripheral-type benzodiazepine ligand [C-11]PK11195 in normal human brain and application in multiple sclerosis patients
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Developing a comprehensive presurgical functional MRI protocol for patients with intractable temporal lobe epilepsy: a pilot study
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Ictal source localization in presurgical patients with refractory epilepsy.
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Iterative reconstruction of magnetic resonance images from arbitrary samples in k-space.
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Motor imagery in mental rotation: An fMRI study.
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Long-term amygdalohippocampal stimulation for refractory temporal lobe epilepsy.
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Language lateralization in epilepsy patients on a 1 Tesla clinical MR scanner using a simple word generation paradigm: results confirmed by Wada-testing
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Developing a comprehensive pre-surgical fMRI protocol for patients with intractable TLE: results of a pilot study
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Functional MR pilot study of stuttering
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99mTc-ECD brain perfusion SPET: variability, asymmetry and effects of age and gender in healthy adults
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Psychiatrische morbiditeit na epilepsiechirurgie
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Morbidité psychiatrique après chirurgie de l'épilepsie
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Nervus vagus stimulatie voor patiënten met refractaire epilepsie
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A patient with rhotacism: a fMRI case report.
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Functional MR pilot study of stuttering.
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T-1 relaxation times for viability evaluation of the engrafted and the native liver in a rat model of heterotopic auxiliary liver transplantation: a pilot study
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57Co SPECT, 99mTc-ECD SPECT, MRI and neuropsychological testing in senile dementia of the Alzheimer type
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Relationship between periventricular or deep white matter lesions and arterial elasticity indices in very old people.
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Human brain chemical shift imaging at age 60 to 90 - Analysis of the causes of the observed sex differences in brain metabolites.
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MR spectroscopy detection of lactate and lipid signals in the brains of healthy elderly people.