prof. dr. ir. Sofie Bekaert
- ORCID iD
- 0000-0002-5716-4896
- Bio (via ORCID)
- Sofie Bekaert is Manager Translational Program at the VIB, where she coordinates the Grand Challenges Program and part-time senior lecturer at the Faculty of Medicine and Health Sciences from Ghent University.. Prof. Sofie Bekaert was trained as a doctor in Applied Biological Engineering. After 10 y of research, setting up a research platform on biological aging, next generation sequencing and biomarkers, she became valorization and innovation manager at Ghent University. In 2010 she initiated the Clinical Research Center at Ghent University Hospital where she had the responsibility over a dedicated team in the daily management of the central point of contact for facilitation of different aspects of translational biomedical research (ethico-legal aspects, datamanagement and monitoring of clinical trials, research and innovation management within the hospital, biobanking, big data). Prof. Bekaert is liaising to strategic translational initiatives concerning biobanking and clinical research and innovation, both at the regional and (inter)national level. She is past-president of the Board of directors of the BBMRI.be, the Belgian node within the European biobank infrastructure network, is Councilor within the European Society for Biopreservation and Biobanking and she is involved in multiple societal valorization projects concerning stakeholder involvement and participation in research (e.g. Eupati, King Baudouin Foundation – multistakeholder dialogue for prioritization of research).
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- Book Chapter
- open access
Biobanking across Europe post-GDPR : a deliberately fragmented landscape
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- Book Chapter
- open access
An overview of Belgian legislation applicable to biobank research and its interplay with data protection rules
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Muscle strength is a major determinant of the blood pressure response to isometric stress testing : the Asklepios population study
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High‐quality biobanks : pivotal assets for reproducibility of OMICS‐data in biomedical translational research
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- Journal Article
- A1
- open access
Biobank quality management in the BBMRI.be network
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- Journal Article
- A1
- open access
Rationalized development of a campus-wide cell line dataset for implementation in the biobank LIMS system at Bioresource center Ghent
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- Journal Article
- A1
- open access
Reversal of aging-induced increases in aortic stiffness by targeting cytoskeletal protein-protein interfaces
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Rationalised development of a campus-wide cell line dataset for implementation in the Bioresource center Ghent LIMS system
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Bioresource centre UZ Ghent : a project-based hospital-integrated biobank : growth through adaptation to customers needs
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- Journal Article
- A2
- open access
Bimetra biobank : a high quality biobank facility to stimulate translational biomedical research
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- Journal Article
- A1
- open access
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
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Telomere length as cardiovascular aging biomarker
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- Journal Article
- A1
- open access
Leukocyte telomere length and diet in the apparently healthy, middle-aged Asklepios population
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Bimetra biobank : achieving sustainability through rationalised change of service at our 5 year anniversary
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BBMRI.vlaanderen : bridging biobanks with research communities in Flanders
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Bimetra biobank : a high quality biobank facility, integrating biobank initiatives
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Telomeres and atherosclerosis : the attrition of an attractive hypothesis
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- Conference Paper
- C3
- open access
How do researchers weigh ethical priciples in pediatric clinical trials?
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- Journal Article
- A1
- open access
Reproducibility of telomere length assessment : an international collaborative study
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Is Southern blotting necessary to measure telomere length reproducibly?: authors' response to: Commentary: The reliability of telomere length measurements
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Reproducibility of telomere length assessment: authors' response to Damjan Krstajic and Ljubomir Buturovic
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- Journal Article
- A1
- open access
Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening
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Bimetra : a ‘star’ on the translational research horizon for both researchers and clinicians
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Quality optimization in the Bimetra tumorbiobank of the UZ Gent
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- Journal Article
- A1
- open access
On cross-sectional associations of leukocyte telomere length with cardiac systolic, diastolic and vascular function: the Asklepios study
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Gender and telomere length: systematic review and meta-analysis
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A non-genetic, epigenetic-like mechanism of telomere length inheritance?
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Arterial stiffness and influences of the metabolic syndrome: a cross-countries study
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Bimetra : platforms for facilitating translational biomedical research
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Bimetra biobank : bringing together different initiatives for high quality biobanking
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Bimetra integrative model for translational research
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Associations between single nucleotide polymorphisms in thyroid hormone transporter genes (MCT8, MCT10 and OATP1C1) and circulating thyroid hormones
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Family history of cardiovascular disease and offspring echocardiographic left ventricular structure and function: the Asklepios study
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- Journal Article
- A1
- open access
Addition of a novel, protective family history category allows better profiling of cardiovascular risk and atherosclerotic burden in the general population: the Asklepios study
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Associations of rs4704397 in phosphodiesterase 8B with thyrotropin and thyroid hormone concentrations
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Translational biomedical research at Ghent
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UZGent Tumorbiobank : key player in an optimal organized quality controlled biobank
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Translational research and multimorbidity
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- Journal Article
- A1
- open access
Molecular diagnostics for congenital hearing loss including 15 deafness genes using a next generation sequencing platform
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No shorter telomeres in subjects with a family history of cardiovascular disease in the Asklepios Study
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Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium
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Low dose irradiation of thyroid cells reveals a unique transcriptomic and epigenetic signature in RET/PTC-positive cells
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- Journal Article
- A1
- open access
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
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- Journal Article
- A1
- open access
Practical tools to implement massive parallel pyrosequencing of PCR products in next generation molecular diagnostics
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Modest opposite associations of endogenous testosterone and oestradiol with left ventricular remodelling and function in healthy middle-aged men
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Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system
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Translational research and multimorbidity : need for a paradigm-shift
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Telomere length and cardiovascular aging: the means to the ends?
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Evaluation of standard and advanced preprocessing methods for the univariate analysis of blood serum 1H-NMR spectra
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Next generation sequencing: (r)evolutie in DNA sequenering en haar rol in de moderne geneeskunde
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- Journal Article
- A1
- open access
Analysing 454 amplicon resequencing experiments using the modular and database oriented Variant Identification Pipeline
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Chromosome 9p21 Polymorphism Interacts With Waist-to-Hip Ratio in Carotid Plaque
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Prevalence of Chlamydophila psittaci infections in a human population in contact with domestic and companion birds
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Amplification of the Pressure Pulse in the Upper Limb in Healthy, Middle-Aged Men and Women
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External X-irradiation causes a decrease in the proliferation of two papillary thyroid carcinoma cell lines with no significant increase in cell death
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Systemic telomere length and preclinical atherosclerosis : the Asklepios study
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E2Fs mediate a fundamental cell-cycle deregulation in high-grade serous ovarian carcinomas
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Circulating oxidized low-density lipoprotein : a biomarker of atherosclerosis and cardiovascular risk?
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Genrisk-T project: response of the TPC-1 papillary thyroid carcinoma cell line to a range of low to high doses of irradiation
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Long term oral contraceptive use is an independent risk factor for arterial stiffening
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Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects
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Femoral Plaques Confound the Association of Circulating Oxidized 951 Low-density Lipoprotein with Carotid Atherosclerosis in a General Population Aged 35-55 Years (Asklepios Study)
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Studying telomeres in a longitudinal population based study
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Lower red blood cell counts in middle-aged subjects with shorter peripheral blood leukocyte telomere length
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Single-nucleotide polymorphisms in DNA double-strand break repair genes: Association with head and neck cancer and interaction with tobacco use and alcohol consumption
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In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia
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Femoral plaques confound the association of circulating oxidized low-density lipoprotein with carotid atherosclerosis in a general population aged 35 to 55 years - The Asklepios study
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Oxidized low-density lipoprotein cholesterol is associated with decreases in cardiac function independent of vascular alterations
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Pubmeth: reviewed methylation database in cancer based on text-mining
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NMR-based characterization of metabolic alterations in hypertension using an adaptive, intelligent binning algorithm
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Telomere biology in giant cell tumour of bone
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- Journal Article
- A1
- open access
PubMeth: a cancer methylation database combining text-mining and expert annotation
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Anticonceptive drug use and increased carotid and femoral plaque prevalence: Population data from asklepios
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Oral contraceptives cause major C-reactive protein rises in the female general population
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- Journal Article
- A1
- open access
Relation between telomerase activity, hTERT and telomere length for intracranial tumours
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Rationale, design, methods and baseline characteristics of the Asklepios Study
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- Journal Article
- A1
- open access
Paternal age at birth is an important determinant of offspring telomere length
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Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease
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Reference values and basic determinants of telomere length in a large middle-aged population
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Is there a "Primus inter pares" of ATP-III metabolic syndrome components in predicting subclinical cardiovascular damage?
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What drives (elevated) high-sensitive CRP in the general population?
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Prevalence of atherosclerosis in middle-age: Results from the asklepios study in 2524 subjects free from overt cardiovascular disease
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Telomere length versus hormonal and bone mineral status in healthy elderly men
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Telomere shortening is associated with malformation in p53-deficient mice after irradiation during specific stages of development
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Telomere attrition as ageing biomarker
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Comparison of different protocols for telomere length estimation by combination of quantitative fluorescence in situ hybridization (Q-FISH) and flow cytometry in human cancer cell lines
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Seizing human biological age
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Accelerated telomere attrition after oxidative stress in human cancer cell lines in the presence of Spirulina
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Telomere shortening in malformed p53-mutant mouse fetuses after irradiation
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Sizing chromosome termini: a valuable biomarker in aging phenotypes
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Telomere attrition rate: a valuable biomarker in aging phenotypes
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Telomere attrition rate: a valuable biomarker in aging phenotypes
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Telomere biology in mammalian germ cells and during development
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Impact of X-irradiation on telomere biology during development in p53-deficient mice
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Comparing telomere length of sister chromatids in human lymphocytes using three dimensional confocal microscopy
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Telomere Biology early in development
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Bron van eeuwig leven
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Het einde in zicht?: de sleutel tot leven en dood ligt vervat in de kern van onze cellen
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Study of telomere length regulation in human-mouse hybrid cell lines
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Telomere shortening observed after fusion of a human isochromosome into a murin fibroblast cel line.
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Telomere size in situ.
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Telomere lengthening in a human mouse hybrid cell line: FISH and CSLM as a tool to measure telomere length of individual chromosomes
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Exopolysaccharide production by the imperfect yeast Sporobolomyces albo-rubescens CBS
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Telomere length regulation and telomerase regulation in a telomerase positive human-murine hybrid cell line
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Telomere length regulation in telomerase positive murine cell line
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Localization of mRNA by fluorescence in situ hybridisation (FISH) on whole mounts of roots of Arabidopsis thaliana
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Use of fluorescence-nucleic-acid (PNA) probes to measure telomere length by fluorescence in situ hybridisation.