prof. dr. Christophe Ampe
work address
Albert Baertsoenkaai 3
9000 Gent
9000 Gent
ORCID iD
0000-0002-8554-3594
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- 2017
- The PET and LIM1-2 domains of testin contribute to intramolecular and homodimeric interactions
- Expanding the interactome of TES by exploiting TES modules with different subcellular localizations
- An end-to-end software solution for the analysis of high-throughput single-cell migration data
- 2016
- Mammalian actins : isoform-specific functions and diseases
- Taking aim at moving targets in computational cell migration
- 2015
- Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure
- Active invadopodia of mesenchymally migrating cancer cells contain both β and γ cytoplasmic actin isoforms
- Delineating the Tes interaction site in zyxin and studying cellular effects of its disruption
- An open data ecosystem for cell migration research
- 2014
- β-Agonists selectively modulate proinflammatory gene expression in skeletal muscle cells via non-canonical nuclear crosstalk mechanisms
- Beta-actin is required for proper mouse neural crest ontogeny
- 2013
- CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP
- Alphaherpesviral US3 kinase induces cofilin dephosphorylation to reorganize the actin cytoskeleton
- p210bcr-abl induces amoeboid motility by recruiting ADF/destrin through RhoA/ROCK1
- Biophysical approaches for investigation of the cytoskeleton: a special issue stemming from research presented at the 2012 ECF meeting: a FEBS/EMBO workshop lecture course in Pécs, Hungary
- Beta-actin is involved in modulating erythropoiesis during development by fine-tuning Gata2 expression levels
- CellMissy: a tool for management, storage and analysis of cell migration data produced in wound healing-like assays
- β-actin knock-out mouse embryonic fibroblasts show increased expression of LIM-, CH-, EFh-domain containing proteins with predicted common upstream regulators
- 2012
- Cells lacking β-actin are genetically reprogrammed and maintain conditional migratory capacity
- The XTT cell proliferation assay applied to cell layers embedded in three-dimensional matrix
- Phosphosite conservation in single domain orthologs versus paralogs: a way to combine differential regulation with redundant core functions
- The US3 kinase of pseudorabies virus leads to activation of the actin regulator cofilin to induce actin cytoskeleton changes
- 2011
- A QUICK screen for Lrrk2 interaction partners: leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics
- Actin and actin filaments
- Intermolecular interaction studies using small volumes
- 2010
- Identification and expression analysis of splice variants of mouse enabled homologue during development and in adult tissues
- 2009
- alpha-Skeletal Muscle Actin Mutants Causing Different Congenital Myopathies Induce Similar Cytoskeletal Defects in Cell Line Cultures
- Unbalancing the phosphatidylinositol-4,5-bisphosphate-cofilin interaction impairs cell steering
- Impaired neural crest migration contributes to midgestation lethality of beta-actin knock-out mouse
- Phenotypes induced by NM causing α-skeletal muscle actin mutants in fibroblasts, Sol 8 myoblasts and myotubes
- alpha-Skeletal muscle actin nemaline myopathy mutants cause cell death in cultured muscle cells.
- An integrative simulation model linking major biochemical reactions of actin-polymerization to structural properties of actin filaments
- The Interaction of Proline-Rich Ligands with Profilin Probed with an Enzyme-Linked Immunosorbent Assay
- Actin isoform expression patterns during mammalian development and in pathology: insights from mouse models
- Algemene biochemie: functionele bouwstenen van het leven
- The Mouse Thymosin Beta15 Gene Family Displays Unique Complexity and Encodes A Functional Thymosin Repeat
- 2008
- Predicting the effect of a point mutation on a protein fold: The villin and advillin headpieces and their Pro62Ala mutants
- S100B Expression in forensic brain trauma fatalities: a valuable tool?
- Ins and outs of ADF/cofilin activity and regulation
- 2007
- Structure-function relationship of actin binding modules studied by NMR
- Atomistic Prediction of the structure of the Advillin headpiece and its Pro62Ala mutant
- Functional and profiling studies prove that prostate cancer upregulated neuroblastoma thymosin beta is the true human homologue of rat thymosin beta 15
- On the origin and evolution of vertebrate and viral profilins
- Structural and Functional Implicationof the PXWK-motif in HeadPiece Domains
- The LIM domains of WLIM1 define a new class of actin bundling modules
- Structural and Functional Implications of the PXWK-motif in HeadPiece Domains
- 2006
- Caenorhabditis elegans expresses three functional profilins in a tissue-specific manner
- Tobacco WLIM1 is a novel F-actin binding protein involved in actin cytoskeleton remodeling
- THE ROLE OF PRO62 AND TRP64 FOR HEADPIECE STABILITY
- The Role of Pro62 and Trp64 for HeadPiece Stability
- Actin interacts with CCT via discrete binding sites: A binding transition-release model for CCT-mediated actin folding
- Multirepeat beta-thymosins
- Profilin-I-ligand interactions influence various aspects of neuronal differentiation
- Identification of the PXW sequence as a structural gatekeeper of the headpiece C-terminal subdomain fold
- Cell_motility: a cross-platform, open source application for the study of cell motion paths
- 2005
- Actin-filament cross-linking protein T-plastin increases Arp2/3-mediated actin-based movement
- A role for complexes of survival of motor neurons (SNM) protein with gemins and profilin in neurite-like cytoplasmic extensions of cultured nerve cells
- Reducing mutational bias in random protein libraries
- Rescue and in situ selection and evaluation (RISE): A method for high-throughput panning of phage display libraries
- 2004
- The folding pathways of actin and tubulins, mechanism of and recognition by the eukaryotic chaperones prefoldin and CCT
- STRUCTURE, FUNCTION AND FOLD STABILITY OF THE HEADPIECE C-TERMINAL SUBDOMAIN
- Solution structures of the C-terminal headpiece subdomains of human villin and advillin, evaluation of headpiece F-actin-binding requirements
- The actin cytoskeleton in normal and pathological cell motility
- Structural plasticity of functional actin: Pictures of actin binding protein and polymer interfaces (vol 11, pg 1279, 2004)
- Myopathy mutations in alpha-skeletal-muscle actin cause a range of molecular defects
- TetraThymosin beta is required for actin dynamics in Caenorhabditis elegans and acts via functionally different actin-binding repeats
- Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding
- 2003
- Structural plasticity of functional actin: Pictures of actin binding protein and polymer interfaces
- A phage display-based method for determination of relative affinities of mutants - Application to the actin-binding motifs in thymosin beta 4 and the villin headpiece
- 2002
- Mutational analysis of human profilin I reveals a second PI(4,5)-P2 binding site neighbouring the poly(L-proline) binding site
- Normalization of nomenclature for peptide motifs as ligands of modular protein domains.
- 2001
- Actin and actin filaments
- 2000
- The competitive interaction of actin and PIP2 with actophorin is based on overlapping target sites: Design of a gain-of-function mutant.
- cAMP-dependent protein kinase phosphorylation of EVL, a mena/VASP relative, regulates its interaction with actin and SH3 domains.
- Profilin II is alternatively spliced, resulting in profilin isoforms that are differentially expressed and have distinct biochemical properties
- Structural requirements for thymosin beta 4 in its contact with actin - An NMR-analysis of thymosin beta 4 mutants in solution and correlation with their biological activity.
- 1999
- Structural modules in actin binding proteins: towards a new classification.
- Effects of natural mutations in lecithin:cholesterol acyltransferase on the enzyme structure and activity
- The cytosolic class II chaperonin CCT recognizes delineated hydrophobic sequences in its target proteins.
- Dimerization of profilin II upon binding the (GP(5))(3) peptide from VASP overcomes the inhibition of actin nucleation by profilin II and thymosin beta 4.
- 1998
- Murine adseverin (D5), a novel member of the gelsolin family, and murine adseverin are induced by interleukin-9 in T-helper lymphocytes
- Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.
- Identification of cofilin, coronin, Rac and capZ in actin tails using a Listeria affinity approach.
- Analysis of three human interleukin 5 structures suggests a possible receptor binding mechanism.
- 1997
- Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors.
- A phage display technique for a fast, sensitive, and systematic investigation of protein-protein interactions.
- The mammalian profilin isoforms display complementary affinities for PIP2 and proline-rich sequences.
- Analogous F-actin binding by cofilin and gelsolin segment 2 substantiates their structural relationship
- 1996
- Cofactor A is a molecular chaperone required for beta-tubulin folding: Functional and structural characterization.
- Pathway leading to correctly folded beta-tubulin.
- Evidence for an actin binding helix in gelsolin segment 2; Have homologous sequences in segments 1 and 2 of gelsolin evolved to divergent actin binding functions?
- The actin binding site of thymosin beta 4 mapped by mutational analysis.
- Detailed quantitative analysis of the actin-binding site of the actin-sequestering protein thymosin beta 4.
- Differential binding of ligands to bovine profilin isoforms.
- 1995
- PURIFICATION AND CHARACTERIZATION OF BOVINE PROFILIN .2. ACTIN, POLY(L-PROLINE) AND INOSITOLPHOSPHOLIPID BINDING.
- Purification and characterization of bovine profilin II. Actin, poly (L-proline) and inositolphospholipid binding
- 1994
- Actin-actin binding protein interfaces
- Purification of a cortical complex containing two unconventional actins from Acanthamoeba by affinity chromatography on profilin-agarose
- A novel cochaperonin that modulates the ATPases activity of cytoplasmic chaperonin.
- Purification of a cortical complex containing 2 unconventional actins from Acanthamoeba by affinity chromatography on profilin-agarose.