prof. dr. apr. Stefaan De Smedt
Show
Sort by
-
Comparison of gold nanoparticle mediated photoporation: vapor nanobubbles outperform direct heating for delivering macromolecules in live cells
-
- Journal Article
- A1
- open access
Understanding ultrasound induced sonoporation: definitions and underlying mechanisms
-
- Journal Article
- A1
- open access
Colloidal stability of nano-sized particles in the peritoneal fluid : towards optimizing drug delivery systems for intraperitoneal therapy
-
- Journal Article
- A1
- open access
On-chip light sheet illumination enables diagnostic size and concentration measurements of membrane vesicles in biofluids
-
- Journal Article
- A1
- open access
The effect of nanoparticle degradation on poly(methacrylic acid)-coated quantum dot toxicity : the importance of particle functionality assessment in toxicology
-
- Journal Article
- A1
- open access
FRAP in pharmaceutical research: practical guidelines and applications in drug delivery
-
Unraveling the effects of siRNA carrier systems on cell physiology: a multiparametric approach demonstrated on dextran nanogels
-
- Journal Article
- A1
- open access
Merging the best of both worlds : hybrid lipid-enveloped matrix nanocomposites in drug delivery
-
- Journal Article
- A1
- open access
Turning a frown upside down: exploiting nanoparticle toxicity for anticancer therapy
-
Transport of nanoparticles in cystic fibrosis sputum and bacterial biofilms by single-particle tracking microscopy
-
In vivo disassembly of IV administered siRNA matrix nanoparticles at the renal filtration barrier
-
Type I IFN counteracts the induction of antigen-specific immune responses by lipid-based delivery of mRNA vaccines
-
Fluorescent non-porous silica nanoparticles for long-term cell monitoring: cytotoxicity and particle functionality
-
Noncoding DNA in lipofection of HeLa cells: a few insights
-
Lipoplexes carrying mRNA encoding Gag protein modulate dendritic cells to stimulate HIV-specific immune responses
-
Measuring the intravitreal mobility of nanomedicines with single-particle tracking microscopy
-
Rectangle FRAP for measuring diffusion with a laser scanning microscope
(2013) Fluorescence spectroscopy and microscopy : methods and protocols. In Methods in Molecular Biology 1076. p.433-441 -
Innate immune response and programmed cell death following carrier-mediated delivery of unmodified mRNA to respiratory cells
-
Current methods for inducing pluripotency in somatic cells
-
Development of nanomedicines for the treatment of pulmonary biofilm infections: Insights from advanced fluorescence microscopy studies
-
Comparison of in vivo optical systems for bioluminescence and fluorescence imaging
-
Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles
-
Targeted liposome-loaded microbubbles for cell-specific ultrasound-triggered drug delivery
-
Enhancing nucleic acid delivery with ultrasound and microbubbles
-
Coupling of drug containing liposomes to microbubbles improves ultrasound triggered drug delivery in mice
-
Light-addressable capsules as caged compound matrix for controlled triggering of cytosolic reactions
-
- Journal Article
- A1
- open access
Polysaccharide-based nucleic acid nanoformulations
-
- Journal Article
- A1
- open access
Assessing nanoparticle toxicity in cell-based assays : influence of cell culture parameters and optimized models for bridging the in vitro-in vivo gap
-
- Journal Article
- A1
- open access
Correlation of dual colour single particle trajectories for improved detection and analysis of interactions in living cells
-
Design and evaluation of theranostic perfluorocarbon particles for simultaneous antigen-loading and 19F-MRI tracking of dendritic cells
-
- Journal Article
- A1
- open access
The influence of natural pulmonary surfactant on the efficacy of siRNA-loaded dextran nanogels
-
The biocompatibility of nanosized materials: intracellular nanoparticle stability and effects on toxicity and particle functionality
-
- Journal Article
- A1
- open access
Focal delivery of AAV2/1-transgenes into the rat brain by localized ultrasound-induced BBB opening
-
siRNA and pharmacological inhibition of endocytic pathways to characterize the differential role of macropinocytosis and the actin cytoskeleton on cellular uptake of dextran and cationic cell penetrating peptides octaarginine (R8) and HIV-Tat
-
- Journal Article
- A1
- open access
The cytotoxic effects of polymer-coated quantum dots and restrictions for live cell applications
-
- Journal Article
- A1
- open access
Intracellular partitioning of cell organelles and extraneous nanoparticles during mitosis
-
Liposome based systems for systemic siRNA delivery: stability in blood sets the requirements for optimal carrier design
-
Tailoring layer-by-layer capsules for biomedical applications
-
Modulation of dendritic cells by lipid grafted polyelectrolyte microcapsules
-
The mechanisms behind sonoporation through the eyes of an AAV-vector
-
Polyelectrolyte LbL microcapsules versus PLGA microparticles for immunization with a protein antigen
-
On the cellular processing of non-viral nanomedicines for nucleic acid delivery: mechanisms and methods
-
Electrospun cellulose acetate phthalate fibers for semen induced anti-HIV vaginal drug delivery
-
- Journal Article
- A1
- open access
Crucial factors and emerging concepts in ultrasound-triggered drug delivery
-
Cytotoxic effects of gold nanoparticles : a multiparametric study
-
Activation of pluripotency-associated genes in mouse embryonic fibroblasts by non-viral transfection with in vitro-derived mRNAs encoding Oct4, Sox2, Klf4 and cMyc
-
The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts
-
Comparison of the gene transfer efficiency of mRNA/GL67 and pDNA/GL67 complexes in respiratory cells
-
Comparison of polymeric siRNA nanocarriers in a murine LPS-activated macrophage cell line: gene silencing, toxicity and off-target gene expression
-
Elucidating the pre- and post-nuclear intracellular processing of 1,4-dihydropyridine based gene delivery carriers
-
Efficient transfection of hepatocytes mediated by mRNA complexed to galactosylated cyclodextrins
-
- Journal Article
- A1
- open access
Limitations and caveats of magnetic cell labeling using transfection agent complexed iron oxide nanoparticles
-
Magnetic electrospun fibers for cancer therapy
-
Matrix systems for siRNA delivery
-
Intracellular drug delivery in Leishmania-infected macrophages: evaluation of saponin-loaded PLGA nanoparticles
-
Internalization of mRNA lipoplexes by dendritic cells
-
- Journal Article
- A1
- open access
Investigating the toxic effects of iron oxide nanoparticles
-
Bio-inspired surfactant-modified dextran nanogels mediate enhanced intracellular siRNA delivery
-
Evaluation of small interfering RNA delivery by nanoparticle-loaded tumoritropic cells
-
An ex vivo assay to measure the mobility inside the eye of nanomedicines for retinal gene therapy
-
Gene and cell therapy for cystic fibrosis : from bench to bedside
-
- Conference Paper
- P1
- open access
Fluorescence single particle tracking for sizing of nanoparticles in undiluted biological fluids
-
Lyophilization of protein-loaded polyelectrolyte microcapsules
-
- Journal Article
- A1
- open access
Nuclear inclusion of nontargeted and chromatin-targeted polystyrene beads and plasmid DNA containing nanoparticles
-
Dynamic colocalization microscopy to characterize intracellular trafficking of nanomedicines
-
mRNA-Lipoplex loaded microbubble contrast agents for ultrasound-assisted transfection of dendritic cells
-
- Journal Article
- A1
- open access
Self-assembled liposome-loaded microbubbles: the missing link for safe and efficient ultrasound triggered drug-delivery
-
Cellular toxicity of inorganic nanoparticles: common aspects and guidelines for improved nanotoxicity evaluation
-
- Journal Article
- A1
- open access
Encapsulation performance of layer-by-layer microcapsules for proteins
-
Particulate vaccines: on the quest for optimal delivery and immune response
-
- Journal Article
- A1
- open access
Hemocompatibility of siRNA loaded dextran nanogels
-
Protein macromonomers containing reduction-sensitive linkers for covalent immobilization and glutathione triggered release from dextran hydrogels
-
Flotillin-dependent endocytosis and a phagocytosis-like mechanism for cellular internalization of disulfide-based poly(amido amine)/DNA polyplexes
-
Elucidating the mechanisms behind sonoporation with adeno-associated virus-loaded microbubbles
-
- Journal Article
- A1
- open access
Fluorescence recovery after photobleaching on the confocal laser-scanning microscope: generalized model without restriction on the size of the photobleached disk
-
- Journal Article
- A1
- open access
Stimuli-responsive electrospun fibers and their applications
-
mRNA as gene therapeutic: how to control protein expression
-
Single particle tracking
-
Vaccination of turkeys against Chlamydophila psittaci through optimised DNA formulation and administration
-
Biodegradable polyelectrolyte microcapsules: antigen delivery tools with Th17 skewing activity after pulmonary delivery
-
Self-exploding capsules
-
Polyelectrolyte capsules-containing HIV-1 p24 and poly I:C modulate dendritic cells to stimulate HIV-1-specific immune responses
-
- Journal Article
- A1
- open access
Unbreakable codes in electrospun fibers : digitally encoded polymers to stop medicine counterfeiting
-
Flexible nanosomes (SECosomes) enable efficient siRNA delivery in cultured primary skin cells and in the viable epidermis of ex vivo human skin
-
- Journal Article
- A1
- open access
Insights in cellular uptake mechanisms of pDNA-polycationic amphiphilic cyclodextrin nanoparticles (CDplexes)
-
- Journal Article
- A1
- open access
PEGylation of biodegradable dextran nanogels for siRNA delivery
-
- Journal Article
- A1
- open access
Efficient delivery of intact phosphodiester oligonucleotides by poly-β-amino esters
-
- Journal Article
- A1
- open access
Prolonged gene silencing by combining siRNA nanogels and photochemical internalization
-
- Journal Article
- A1
- open access
The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls
-
High intracellular iron oxide nanoparticle concentrations affect cellular cytoskeleton and focal adhesion kinase-mediated signaling
-
Colour-coded microcarriers: made to move
-
mRNA transfection of cervical carcinoma and mesenchymal stem cells mediated by cationic carriers
-
- Journal Article
- A1
- open access
Photopolymerized thermosensitive poly(HPMAlactate)-PEG-based hydrogels : effect of network design on mechanical properties, degradation, and release behavior
-
Impact of chronic pulmonary infection with Pseudomonas aeruginosa on transfection mediated by viral and nonviral vectors
-
- Journal Article
- A1
- open access
Sizing nanomatter in biological fluids by fluorescence single particle tracking
-
Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy
-
Design and evaluation of doxorubicin-containing microbubbles for ultrasound-triggered doxorubicin delivery: cytotoxicity and mechanisms involved
-
Advanced fluorescence microscopy methods illuminate the transfection pathway of nucleic acid nanoparticles
-
Pulmonary delivery of mRNA: in vitro and in vivo evaluation
-
Transport and delivery of antimicrobial agents in Burkholderia biofilms