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Paracellular entry of interleukin-10 producing Lactococcus lactis in inflamed intestinal mucosa in mice
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Intracellular accumulation of trehalose protects Lactococcus lactis from freeze-drying damage and bile toxicity and increases gastric acid resistance
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Therapeutic drug delivery by genetically modified Lactococcus lactis
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Altered gut transcriptome in spondyloarthropathy
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Genetically modified Lactococcus lactis: novel tools for drug delivery
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Clinical potential of Lactococcus lactis mediated delivery of human Interleukin-10 and Trefoil Factors
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A phase I trial with Transgenic bacteria expressing interleukin-10 in Crohn's disease
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- Journal Article
- A1
- open access
CARD15 gene polymorphisms in patients with spondyloarthropathies identify a specific phenotype previously related to Crohn's disease
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Development of an enteric-coated formulation containing freeze-dried, viable recombinant Lactococcus lactis for the ileal mucosal delivery of human interleukin-10
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Evaluation of extrusion/spheronisation, layering and compaction for the preparation of an oral, multi-particulate formulation of viable, hIL-10 producing Lactococcus lactis
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Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice
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CARD15 mutations in patients with spondyloarthropathy are linked with disease progression and evolution to Crohn's disease
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Crohn's disease patients with CARD15 variants have higher risk of developing axial joint involvement
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Biological containment of genetically modified Lactococcus lactis for intestinal delivery of human interleukin 10
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Cytokines, chemokines and growth factors in the pathogenesis and treatment of inflammatory bowel disease
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- Journal Article
- A1
- open access
Overexpression of alpha(1)-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis.
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In situ delivery of cytokines by genetically engineered Lactococcus lactis.
(2002) ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY. 82(1-4). p.323-331 -
In situ delivery of cytokines at mucosal surfaces by genetically engineered Lactococcus lactis
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Lactococcus lactis, a tool for the delivery of therapeutic proteins. Treatment of IBD.
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In situ delivery of cytokines at mucosal surfaces by genetically engineered Lactococcus lactis.
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Microbiological and immunological strategies for treatment of inflammatory bowel disease.
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Secretion of biologically active murine interleukin-10 by Lactococcus lactis.
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Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.
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- Journal Article
- A1
- open access
Mucosal delivery of murine interleukin-2 (IL-2) and IL-6 by recombinant strains of Lactococcus lactis coexpressing antigen and cytokine.
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Functional display of a heterologous protein on the surface of Lactococcus lactis by means of the cell wall anchor of Staphylococcus aureus protein A
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Expression of human and murine interleukins in Lactococcus lactis
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The expression of the Photinus pyralis luciferase gene in Staphylococcus aureus Cowan I allows the development of a live amplifiable tool for immunodetection.
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PRODUCTION OF SOLUBLE AND ACTIVE RECOMBINANT MURINE INTERLEUKIN-2 IN ESCHERICHIA-COLI - HIGH-LEVEL EXPRESSION, KIL-INDUCED RELEASE, AND PURIFICATION.
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SIMULTANEOUS LIGHT-EMISSION FROM CLONED VIBRIO-FISCHERI LUX GENES AND EXPRESSION OF LAMB OR LAMB PROTEIN-A FUSION PROTEINS IN ESCHERICHIA-COLI DEPENDS ON USING A SINGLE CHIMERIC OPERON.
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SECRETION OF BIOLOGICALLY-ACTIVE MURINE INTERLEUKIN-2 BY LACTOCOCCUS-LACTIS SUBSP LACTIS.
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Efficient specific release of periplasmic proteins from Escherichia coli using temperature induction of cloned kil gene of pMB9.
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Pap pili as a vector system for surface exposition of an immunoglobulin G-binding domain of protein-A of Staphylococcus-aureus in Escherichia-coli.
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LamB as a carrier molecule for the functional exposition of IgG-binding domains of the Staphylococcus aureus protein A at the surface of Escherichia coli K12.