prof. dr. Jan Gettemans

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Cortactin and fascin-1 regulate extracellular vesicle release by controlling endosomal trafficking or invadopodia formation and function

Els Beghein, Delphine Devriese, Evy Van Hoey and Jan Gettemans (UGent)

(2018) SCIENTIFIC REPORTS. 8.
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Nanobodies targeting cortactin proline rich, helical and actin binding regions downregulate invadopodium formation and matrix degradation in SCC-61 cancer cells

Laurence Bertier (UGent) , Tim Hebbrecht, Elien Mettepenningen, Natasja De Wit, Olivier Zwaenepoel (UGent) , Adriaan Verhelle (UGent) and Jan Gettemans (UGent)

(2018) BIOMEDICINE & PHARMACOTHERAPY. 102. p.230-241
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Nanobody technology : a versatile toolkit for microscopic imaging, protein-protein interaction analysis, and protein function exploration

Els Beghein and Jan Gettemans (UGent)

(2017) FRONTIERS IN IMMUNOLOGY. 8.
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VCA nanobodies target N-WASp to reduce invadopodium formation and functioning

Tim Hebbrecht, Isabel Van Audenhove (UGent) , Olivier Zwaenepoel (UGent) , Adriaan Verhelle (UGent) and Jan Gettemans (UGent)

(2017) PLOS ONE. 12(9).
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EV-TRACK : transparent reporting and centralizing knowledge in extracellular vesicle research

Jan Van Deun (UGent) , Pieter Mestdagh (UGent) , Patrizia Agostinis, Özden Akay, Sushma Anand, Jasper Anckaert, Zoraida Andreu Martinez, Tine Baetens, Els Beghein, Laurence Bertier (UGent) , et al.

(2017) NATURE METHODS. 14(3). p.228-232
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AAV9 delivered bispecific nanobody attenuates amyloid burden in the gelsolin amyloidosis mouse model

Adriaan Verhelle (UGent) , Nair Nisha, Inge Everaert (UGent) , Wouter Van Overbeke (UGent) , Lynn Supply (UGent) , Olivier Zwaenepoel (UGent) , Cindy Peleman, Jo Van Dorpe (UGent) , Tony Lahoutte, Nick Devoogdt, et al.

(2017) HUMAN MOLECULAR GENETICS. 26(7). p.1353-1364
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Inhibitory cortactin nanobodies delineate the role of NTA- and SH3-domain-specific functions during invadopodium formation and cancer cell invasion

Laurence Bertier (UGent) , Ciska Boucherie (UGent) , Olivier Zwaenepoel (UGent) , Berlinda Vanloo (UGent) , Marleen Van Troys (UGent) , Isabel Van Audenhove (UGent) and Jan Gettemans (UGent)

(2017) FASEB JOURNAL. 31(6). p.2460-2476
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A nanobody‐based approach to amyloid diseases, the gelsolin case study

Adriaan Verhelle (UGent) and Jan Gettemans (UGent)

(2016) Exploring new findings on amyloidosis. p.313-335
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The tax-inducible actin-bundling protein fascin is crucial for release and cell-to-cell transmission of human T-cell leukemia virus type 1 (HTLV-1)

Christine Gross, Veit Wiesmann, Sebastian Millen, Martina Kalmer, Thomas Wittenberg, Jan Gettemans (UGent) and Andrea K Thoma-Kress

(2016) PLOS PATHOGENS. 12(10).
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A new survivin tracer tracks, delocalizes and captures endogenous survivin at different subcellular locations and in distinct organelles

Els Beghein, Isabel Van Audenhove (UGent) , Olivier Zwaenepoel (UGent) , Adriaan Verhelle (UGent) , Ariane De Ganck (UGent) and Jan Gettemans (UGent)

(2016) SCIENTIFIC REPORTS. 6.
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Nanobodies as versatile tools to understand, diagnose, visualize and treat cancer

Isabel Van Audenhove (UGent) and Jan Gettemans (UGent)

(2016) EBIOMEDICINE. 8. p.40-48
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- Book Chapter
Use of nanobodies to localize endogenous cytoskeletal proteins and to determine their contribution to cancer cell invasion by using an ECM degradation assay

Isabel Van Audenhove (UGent) and Jan Gettemans (UGent)

(2016) Cytoskeleton : methods and protocols. In Methods in Molecular Biology 1365. p.225-241
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Fascin rigidity and L-plastin flexibility cooperate in cancer cell invadopodia and filopodia

Isabel Van Audenhove (UGent) , Majken Denert (UGent) , Ciska Boucherie (UGent) , Leen Pieters (UGent) , Maria Cornelissen (UGent) and Jan Gettemans (UGent)

(2016) JOURNAL OF BIOLOGICAL CHEMISTRY. 291(17). p.9148-9160
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Non-invasive imaging of amyloid deposits in a mouse model of AGel using 99mTc-modified nanobodies and SPECT/CT

Adriaan Verhelle (UGent) , Wouter Van Overbeke (UGent) , Cindy Peleman, Rebecca De Smet (UGent) , Olivier Zwaenepoel (UGent) , Tony Lahoutte, Jo Van Dorpe (UGent) , Nick Devoogdt and Jan Gettemans (UGent)

(2016) MOLECULAR IMAGING AND BIOLOGY. 18(6). p.887-897
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Fascin actin bundling controls podosome turnover and disassembly while cortactin is involved in podosome assembly by its SH3 domain in THP-1 macrophages and dendritic cells

Isabel Van Audenhove (UGent) , Nincy Debeuf (UGent) , Ciska Boucherie (UGent) and Jan Gettemans (UGent)

(2015) BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1853(5). p.940-952
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An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model

Wouter Van Overbeke (UGent) , Jantana Wongsantichon, Inge Everaert (UGent) , Adriaan Verhelle (UGent) , Olivier Zwaenepoel (UGent) , Anantasak Loonchanta, Leslie D Burtnick, Ariane De Ganck (UGent) , Tino Hochepied (UGent) , Jody Haigh (UGent) , et al.

(2015) HUMAN MOLECULAR GENETICS. 24(9). p.2492-2507
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A nanobody modulates the p53 transcriptional program without perturbing its functional architecture

Jonas Bethuyne (UGent) , Steven De Gieter, Olivier Zwaenepoel (UGent) , Abel Garcia-Pino, Kaat Durinck (UGent) , Adriaan Verhelle (UGent) , Gholamreza Hassanzadeh-Ghassabeh, Franki Speleman (UGent) , Remy Loris and Jan Gettemans (UGent)

(2014) NUCLEIC ACIDS RESEARCH. 42(20). p.12928-12938
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Chaperone nanobodies protect gelsolin against MT1-MMP degradation and alleviate amyloid burden in the gelsolin amyloidosis mouse model

Wouter Van Overbeke (UGent) , Adriaan Verhelle (UGent) , Inge Everaert (UGent) , Olivier Zwaenepoel (UGent) , Joël Vandekerckhove (UGent) , Claude Cuvelier (UGent) , Wim Derave (UGent) and Jan Gettemans (UGent)

(2014) MOLECULAR THERAPY. 22(10). p.1768-1778
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Stratifying fascin and cortactin function in invadopodium formation using inhibitory nanobodies and targeted subcellular delocalization

Isabel Van Audenhove (UGent) , Ciska Boucherie (UGent) , Leen Pieters (UGent) , Olivier Zwaenepoel (UGent) , Berlinda Vanloo (UGent) , Evelien Martens (UGent) , Charlotte Verbrugge, Gholamreza Hassanzadeh-Ghassabeh, Joël Vandekerckhove (UGent) , Maria Cornelissen (UGent) , et al.

(2014) FASEB JOURNAL. 28(4). p.1805-1818
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A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis

Katrien Van Impe (UGent) , Jonas Bethuyne (UGent) , Steven Cool, Francis Impens (UGent) , David Ruano-Gallego, Olivier De Wever (UGent) , Berlinda Vanloo (UGent) , Marleen Van Troys (UGent) , Kathleen Lambein (UGent) , Ciska Boucherie (UGent) , et al.

(2013) BREAST CANCER RESEARCH. 15(6).

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Academic Bibliography

prof. dr. Jan Gettemans

Cortactin and fascin-1 regulate extracellular vesicle release by controlling endosomal trafficking or invadopodia formation and function

Nanobodies targeting cortactin proline rich, helical and actin binding regions downregulate invadopodium formation and matrix degradation in SCC-61 cancer cells

Nanobody technology : a versatile toolkit for microscopic imaging, protein-protein interaction analysis, and protein function exploration

VCA nanobodies target N-WASp to reduce invadopodium formation and functioning

EV-TRACK : transparent reporting and centralizing knowledge in extracellular vesicle research

AAV9 delivered bispecific nanobody attenuates amyloid burden in the gelsolin amyloidosis mouse model

Inhibitory cortactin nanobodies delineate the role of NTA- and SH3-domain-specific functions during invadopodium formation and cancer cell invasion

A nanobody‐based approach to amyloid diseases, the gelsolin case study

The tax-inducible actin-bundling protein fascin is crucial for release and cell-to-cell transmission of human T-cell leukemia virus type 1 (HTLV-1)

A new survivin tracer tracks, delocalizes and captures endogenous survivin at different subcellular locations and in distinct organelles

Nanobodies as versatile tools to understand, diagnose, visualize and treat cancer

Use of nanobodies to localize endogenous cytoskeletal proteins and to determine their contribution to cancer cell invasion by using an ECM degradation assay

Fascin rigidity and L-plastin flexibility cooperate in cancer cell invadopodia and filopodia

Non-invasive imaging of amyloid deposits in a mouse model of AGel using 99mTc-modified nanobodies and SPECT/CT

Fascin actin bundling controls podosome turnover and disassembly while cortactin is involved in podosome assembly by its SH3 domain in THP-1 macrophages and dendritic cells

An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model

A nanobody modulates the p53 transcriptional program without perturbing its functional architecture

Chaperone nanobodies protect gelsolin against MT1-MMP degradation and alleviate amyloid burden in the gelsolin amyloidosis mouse model

Stratifying fascin and cortactin function in invadopodium formation using inhibitory nanobodies and targeted subcellular delocalization

A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis

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