prof. dr. apr. Jan Van Bocxlaer
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- Journal Article
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Effects of food and pharmaceutical formulation on desmopressin pharmacokinetics in children
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Antimicrobial effect of a single dose of amoxicillin on the oral microbiota
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Bioequivalence in adults is not always bioequivalence in children
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Effect of food and pharmaceutical formulation on desmopressin pharmacokinetics in children
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PK/PD modelling of the QT interval : a step towards defining the translational relationship between in vitro, awake Beagle dogs, and humans
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A model-based analysis of the predictive performance of different renal function markers for cefepime clearance in the ICU
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- Conference Paper
- C3
- open access
Interaction between Fusarium mycotoxins and cytochrome P450 drug metabolizing enzymes/ABC drug transporters in a porcine animal model
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What about confidence intervals? : a word of caution when interpreting PTA simulations
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- Journal Article
- A1
- open access
Hot-melt extrusion of polyvinyl alcohol for oral immediate release applications
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- Journal Article
- A1
- open access
Physiology-based IVIVE predictions of tramadol from in vitro metabolism data
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- Journal Article
- A1
- open access
Degradable ketal-based block copolymer nanoparticles for anticancer drug delivery : a systematic evaluation
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- Journal Article
- A1
- open access
Drug administration via enteral feeding tubes in residential care facilities for individuals with intellectual disability : an observational study
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Physiologically based pharmacokinetic predictions of tramadol exposure throughout pediatric life: an analysis of the different clearance contributors with emphasis on CYP2D6 maturation
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Modelling of drug-induced QT-interval prolongation: estimation approaches and translational opportunities
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Age-related differences in CYP3A abundance and activity in the liver of the Gottingen Minipig
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The ontogeny of hepatic CYP3A, CYP2C and CYP2E enzyme activity in conventional pigs
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- Journal Article
- A1
- open access
Quantification of cytochrome 2E1 in human liver microsomes using a validated indirect ELISA
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- Journal Article
- A1
- open access
Formulation of itraconazole nanococrystals and evaluation of their bioavailability in dogs
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Medication management in Belgian residential care facilities for individuals with intellectual disability: an observational study
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- Journal Article
- A1
- open access
Enzymatic tumour tissue digestion coupled to SPE-UPLC–tandem mass spectrometry as a tool to explore paclitaxel tumour penetration
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A model based analysis of IPEC dosing of paclitaxel in rats
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- Journal Article
- A1
- open access
Moxifloxacin dosing in post-bariatric surgery patients
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Microsomal protein per gram of liver (MPPGL) in paediatric biliary atresia patients
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Untargeted screening of secondary metabolites in fungal cultures and samples from mouldy indoor environments by time-of-flight mass spectrometry
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Disulfiram inhibition of cyanide formation after acetonitrile poisoning
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Hepatic and intestinal CYP3A expression and activity in broilers
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Toxic effects of dietary exposure to T-2 toxin on intestinal and hepatic biotransformation enzymes and drug transporter systems in broiler chickens
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The mycotoxin T-2 inhibits hepatic cytochrome P4503A activity in pigs
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- Journal Article
- A1
- open access
The influence of bypass procedures and other anatomical changes in the gastrointestinal tract on the oral bioavailability of drugs
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Development and validation of a fast and uniform approach to quantify β-lactam antibiotics in human plasma by solid phase extraction-liquid chromatography-electrospray-tandem mass spectrometry
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In vitro cytochrome P450 activity decreases in children with high paediatric end-stage liver disease scores
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Metabolism of hop-derived bitter acids
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- Conference Paper
- C3
- open access
Moxifloxacin dosing in post-bariatric surgery patients: another nail in the coffin of the 'one dose fits all' paradigm
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- Journal Article
- A1
- open access
Formulation of poorly water-soluble drugs via coacervation : a pilot study using febantel
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Development and validation of a fast and sensitive UPLC-MS/MS method for the quantification of six probe metabolites for the in vitro determination of cytochrome P450 activity
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Development and validation of an enzyme-linked immunosorbent assay for the quantification of cytochrome 3A4 in human liver microsomes
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Switch from intravenous to enteral moxifloxacin in critically ill patients: a pilot study
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Hypervariable cytochrome P450 activity in children with severe hepatic dysfunction
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Flavonoid deactivation of excited state flavins: reaction monitoring by mass spectrometry
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Analytical performance evaluation of four cartridge-type blood gas analyzers
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Impact of corneal cross-linking on drug penetration in an ex vivo porcine eye model
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Oral bioavailability of moxifloxacin after Roux-en-Y gastric bypass surgery
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- Journal Article
- A1
- open access
Development of a nanocrystalline Paclitaxel formulation for HIPEC treatment
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Pharmacokinetics of two formulations of omeprazole administered through a gastrostomy tube in patients with severe neurodevelopmental problems
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Evaluation of three state-of-the-art metabolite prediction software packages (Meteor, MetaSite, and StarDrop) through independent and synergistic use
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In vitro cytochrome P450 activity: development and validation of a sensitive high performance liquid chromatography–tandem mass spectrometry method for the quantification of six probe metabolites after derivatization with pyridine-3-sulfonyl chloride in an aqueous environment
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Human salivary cortisol, part I : development and full validation of an LC-MS/MS based method
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Bioavailability of hop-derived iso-α-acids and reduced derivatives
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An evaluation of using population pharmacokinetic models to estimate pharmacodynamic parameters for propofol and bispectral index in children
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Analysis of omnoponum by surface-ionization mass spectrometry and liquid chromatography tandem mass spectrometry methods