prof. dr. Filip De Keyser
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Validation of a manual ability questionnaire in patients with systemic sclerosis
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Reversible changes in serum immunoglobulin galactosylation during the immune response and treatment of inflammatory autoimmune arthritis
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Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis
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Clinical Observations programme in SpA: disease parameters, treatment options and practical management issues
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Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus
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Validation of a new screening strategy for anti-extractable nuclear antigen antibodies
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- Conference Paper
- C3
- open access
Identification and possible citrullination of antigens in immune complexes in patients with rheumatoid arthritis
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Validation of a new screening strategy for anti-ENA antibodies
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Over-representation of construction-related occupations in male patients with systemic sclerosis
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- Journal Article
- A1
- open access
Synovial detection and autoantibody reactivity of processed citrullinated isoforms of vimentin in inflammatory arthritides
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- Conference Paper
- C3
- open access
Reduced metallothionein expression in colonic Crohn's disease: evidence for a new disease-modifying gene
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Local and systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis
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Spontaneous amelioration in early RA: Role of antibody profiles in predicting decrease of disease activity
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Do all anti-citrullinated protein/peptide antibody tests measure the same? Evaluation of discrepancy between anti-citrullinated protein/peptide antibody tests in patients with and without rheumatoid arthritis
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Prediction models for disease: The effect of associations between markers on calculating the risk for disease by likelihood ratio products in SpA
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Tapering infliximab dosages after temporary dose increase does not affect treatment survival in an established RA population
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Reduced metallothionein expression in colonic Crohn's disease: evidence for it new disease-modifying gene
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Spondyloarthropathies
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Re: Pulmonary arterial hypertension in connective tissue diseases
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CARD15 variants determine a disturbed early response of monocytes to adherent-invasive Escherichia coli strain LF82 in Crohn's disease
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Anti-TNF-therapie bij patiënten met chronische artritis
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Specifieke antinucleaire antilichamen bij patiënten met systeemsclerose
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- Journal Article
- A1
- open access
Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis
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Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis and may have an added value in prediction models
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Non-pathogenic antinuclear antibodies contribute to the clearance of apoptotic antigens released during TNF alpha blockade in spondyloarthritis (SpA)
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Anti-TNFalpha induced apoptosis contributes to the induction of autoantibodies but not the decrease of synovial inflammation in spondyloarthropathy (SpA)
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Comparison of different outcome measures for psoriatic arthritis in patients treated with infliximab or placebo
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Decrease of disease activity under ineffective therapy in DMARD-naive patients with early rheumatoid arthritis: Role of antibody profiles and carriage of the HLA shared epitope in predicting decrease of disease activity
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Endogenous HLA-DR-restricted presentation of the cartilage antigens human cartilage gp-39 and melanoma inhibitory activity in the inflamed rheumatoid joint
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Effects of intra-articular corticosteroids and anti-TNF therapy on neutrophil activation in rheumatoid arthritis
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In pursuit of B-cell synovial autoantigens in rheumatoid arthritis: Confirmation of citrullinated fibrinogen, detection of vimentin, and introducing carbonic anhydrase as a possible new synovial autoantigen
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A prospective randomised multicentre study comparing continuous and intermittent treatment with celecoxib in patients with osteoarthritis of the knee or hip
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Prediction models for rheumatoid arthritis during diagnostic investigation: evaluation of combinations of rheumatoid factor, anti-citrullinated protein/peptide antibodies and the human leucocyte antigen-shared epitope
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Spondyloarthropathies
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Leflunomide and methotrexate combination therapy in daily clinical practice
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Altered gut transcriptome in spondyloarthropathy
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The diagnostic value of the anti-human citrullinated fibrinogen antibodies by elisa compared to anti-CCP2 antibodies, and their agreement with ACPA detected by 3 other substrates
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Four-year follow-up of infliximab therapy in rheumatoid arthritis patients with long-standing refractory disease: attrition and long-term evolution of disease activity
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Prediction of dose escalation for rheumatoid arthritis patients under infliximab treatment
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Synovial inflammation does not change in the absence of effective treatment: implications for the use of synovial histopathology as biomarker in early phase clinical trials in rheumatoid arthritis
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Four year follow-up of infliximab in rheumatoid arthritis patients refractory to multiple dmard treatment: Long-term clinical effect and prediction of attrition
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Comparison of the anti-human citrullinated fibrinogen antibodies assayed by ELISA with 2 other ACPA assays: Diagnostic value and agreement between assays
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Anti-TNFalpha induced apoptosis contributes to the induction of autoantibodies but not the decrease of synovial inflammation in spondyloarthropathy
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Anti-TNF alpha induced apoptosis contributes to the induction of Autoantibodies but not the decrease of synovial inflammation in spondyloarthropathy (SPA)
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Growth promoting effect of human cartilage glycoprotein-39 (HC gp-39) on synovial fibroblasts
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Identification of synovial biomarkers of response to experimental treatment in early-phase clinical trials in spondylarthritis
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Diagnostic value of anti-human citrullinated fibrinogen ELISA and comparison with four other anti-citrullinated protein assays
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Polymorphisms in the ficolin 1 gene (Fcn1) are associated with susceptibility to the development of rheumatoid arthritis
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Identification of synovial biomarkers of response to treatment in spondyloarthropathy
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Anti-TNF-alpha therapy in ankylosing spondylitis
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Effect of age on prevalence of anticitrullinated protein/peptide antibodies in polyarticular juvenile idiopathic arthritis
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Accuracy of anti-ribosomal P protein antibody testing for the diagnosis of neuropsychiatric systemic lupus erythematosus - An international meta-analysis
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Mannose-binding lectin (MBL2) polymorphisms in rheumatoid arthritis (RA) are not associated with susceptibility or radiological progression rate
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Alternative method to identify susceptibility genes for Crohn's disease through transcriptome analysis
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Differential expression of hypoxia activated proteins in synovial tissue of inflammatory arthritides
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Comparison of Machine Learning models for prediction of dose increase in patients with rheumatoid arthritis
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Feature selection in the prediction of Infliximab dose increase
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Rheumatoid factor, but not anti-cyclic citrullinated peptide antibodies, is modulated by infliximab treatment in rheumatoid arthritis
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The effect of TNFalpha blockade on the antinuclear antibody profile in patients with chronic arthritis: biological and clinical implications
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Infliximab, but not etanercept, induces IgM anti-double-stranded DNA autoantibodies as main antinuclear reactivity : biologic and clinical implications in autoimmune arthritis
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Comparing statistics with machine learning models to predict dose increase of infliximab for rheumatoid arthritis patients
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CARD15 polymorphisms are associated with anti-Saccharomyces cerevisiae antibodies in caucasian Crohn's disease patients
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Relative increase in lung volume in fetuses with congenital diaphragmatic hernia treated by fetoscopic endoluminal tracheal occlusion (FETO)
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S100A12-expression is upregulated by TNF and may serve as a marker for the success of anti-TNF therapy
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Growth promoting effect of human cartilage glycoprotein-39 (HC gp-39)on synovial fibroblasts
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Local production of the cartilage protein melanoma inhibitory activity (MIA) in the inflamed joint: Disease specificity, regulation by IL-1, and association with radiological joint damage
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Functional haplotypes of PAD14: Relevance for rheumatoid arthritis-specific synovial intracellular citruillinated proteins and anti-citrullinated protein antibodies
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Das28 correlates best with the physician's clinical judgment of response to infliximab therapy in rheumatoid arthritis patients
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Impact of natural changes in disease activity on synovial histopathology in rheumatoid arthritis
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Tumor necrosis factor a blockade treatment down-modulates the increased systemic and local expression of toll-like receptor 2 and toll-like receptor 4 in spondylarthropathy
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- Journal Article
- A1
- open access
Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy
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Histological evidence that infliximab treatment leads to downregulation of inflammation and tissue remodelling of the synovial membrane in spondyloarthropathy
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Chronically inflamed synovium from spondyloarthropathy and rheumatoid arthritis investigated by protein expression profiling followed by tandem mass spectrometry
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Bowel inflammation in rheumatic diseases: Trigger or consequence
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Short and long term synovial immunumodulation by etanercept in spondyloarthropathy
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5-year safety and efficacy follow-up in 107 spondyloarthropathy patients with continued long-term infliximab treatment
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- Journal Article
- A1
- open access
DAS28 best reflects the physician's clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment
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Anti-citrullinated peptide antibodies may occur in patients with psoriatic arthritis
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Effective immunomodulation of peripheral joint pathology in spondyloarthropathy by etanercept
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DAS28 is a robust measure of the physician's clinical judgment of response infliximab therapy
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Preliminary evidence for a retardation of structural damage in patients with ankylosing spondylitis continuously treated with infliximab for 4 years
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Immunomodulatory effects of etanercept on peripheral joint synovitis in the spondylarthropathies
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Diagnostic performance and predictive value of rheumatoid factor, anti-citrullinated peptide antibodies, and the HLA shared epitope for diagnosis of rheumatoid arthritis
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Mannose-binding lectin (MBL2) polymorphisms in rheumatoid arthritis (RA) are not associated with susceptibility or radiological progression rate
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Colon mucosa of patients both with spondyloarthritis and Crohn's disease is enriched with macrophages expressing the scavenger receptor CD163
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Tumor necrosis factor-alpha blockade in ankylosing spondylitis: a potent but expensive anti-inflammatory treatment or true disease modification?
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- Journal Article
- A1
- open access
Synovial histopathology of psoriatic arthritis, both oligo- and polyarticular, resembles spondyloarthropathy more than it does rheumatoid arthritis
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Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase are pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity
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Juvenile chronic arthritis displays synovial features distinct from both spondyloarthropathy and rheumatoid arthritis
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Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity
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Mannose-binding lectin (Mbl2) polymorphisms in rheumatoid arthritis are not associated with susceptibility, radiological progression rate, or serological markers
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Identification of synovial biomarkers of response to treatment in spondyloarthropathy
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Involvement of neurotrophins and their receptors in spondyloarthritis synovitis: relation to inflammation and response to treatment
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Anti-citrullinated protein/peptide antibodies (ACPA) in rheumatoid arthritis: Specificity and relation with rheumatoid factor
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Functional haplotypes of PADI4: relevance for rheumatoid arthritis specific synovial intracellular citrullinated proteins and anticitrullinated protein antibodies
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Mannose-binding lectin polymorphisms in rheumatoid arthritis and the associations with radiological progression rate and serological markers
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IgM anti-dsDNA autoantibodies are the main antinuclear reactivity induced by infliximab but not etanercept treatment in vivo: Biological and clinical implications
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Human cartilage glycoprotein-39 (HC gp-39) as growth factor for synovial fibroblasts
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The cartilage protein Melanoma Inhibitory Activity (MIA) is produced locally in the arthritic joint but does not correlate with radiological joint damage
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Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase are pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity