em. prof. dr. Romain Lefebvre
- ORCID iD
- 0000-0003-2356-3714
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Hemin reduces postoperative ileus in a heme oxygenase 1‐dependent manner while dimethyl fumarate does without heme oxygenase 1‐induction
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- Journal Article
- A1
- open access
The H2S-releasing naproxen derivative ATB-346 and the slow-release H2S donor GYY4137 reduce intestinal inflammation and restore transit in postoperative ileus
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- Conference Paper
- C3
- open access
Influence of the slow- release H2S donor GYY4137 and the H2S- releasing naproxen derivative ATB-346 on postoperative ileus
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- Conference Paper
- C3
- open access
Dimethyl fumarate vs hemin for the induction of heme oxygenase-1 as treatment strategy for murine postoperative ileus
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Investigation of orally delivered carbon monoxide for postoperative ileus
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- Journal Article
- A1
- open access
cAMP catalyzing phosphodiesterases control cholinergic muscular activity but their inhibition does not enhance 5-HT4 receptor-mediated facilitation of cholinergic contractions in the murine gastrointestinal tract
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- Conference Paper
- C3
- open access
Influence of the slow-release H2S donor GYY4137 and the H2S-releasing naproxen derivative ATB-346 on postoperative ileus
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Synergy between 5-HT4 receptor stimulation and phosphodiesterase 4 inhibition in facilitating acetylcholine release in human large intestinal circular muscle
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Investigation to prevent postoperative ileus via peroral CO
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Influence of dimethyl fumarate on murine postoperative ileus
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5-HT4 receptors facilitate cholinergic neurotransmission throughout the murine gastrointestinal tract
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The 5-HT4 receptor agonist prucalopride does not facilitate cholinergic neurotransmission in circular and longitudinal smooth muscle preparations of equine mid-jejunum
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Dimethyl fumarate improves murine postoperative ileus independently of heme oxygenase-1
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Influence of phosphodiesterases on basal and 5-HT4 receptor-facilitated cholinergic contractility in the murine gastrointestinal tract
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- Journal Article
- A1
- open access
Differential effects of CORM-2 and CORM-401 in murine intestinal epithelial MODE-K cells under oxidative stress
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The signaling pathway of 5-HT4 receptors in cholinergic neurons of human colon is controlled by phosphodiesterases
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Is there evidence for functional 5-hydroxytryptamine 4 (5-HT4) receptors in the equine jejunum?
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Synergistic effect between 5-HT4 receptor agonist and phosphodiesterase 4-inhibitor in releasing acetylcholine in pig gastric circular muscle in vitro
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Corneel Heymans, de Gentse Nobelprijswinnaar
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Control of the signalling pathway of 5-HT4 receptors in cholinergic neurons of human colon by phosphodiesterases
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Presynaptic M₃ muscarinic cholinoceptors mediate inhibition of excitatory synaptic transmission in area CA1 of rat hippocampus
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Is there evidence for functional 5-hydroxytryptamine 4 (5-HT4) receptors in the equine jejunum?: an in vitro study to explore options for use of human prokinetic drugs, acting as 5-HT4 receptors in horses
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Protective effect of exogenous nitrite in postoperative ileus
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Antioxidant potential of CORM-A1 and resveratrol during TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells
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- Conference Paper
- C3
- open access
Facilitation of cholinergic neurotransmission via 5-HT4 receptors in the murine gastrointestinal tract
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- Conference Paper
- C3
- open access
Facilitation of murine enteric cholinergic neurotransmission by 5-HT4 receptor activation : control by phosphodiesterases
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Mitochondria and NADPH oxidases are the major sources of TNF-α/cycloheximide-induced oxidative stress in murine intestinal epithelial MODE-K cells
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CO and CO-releasing molecules (CO-RMs) in acute gastrointestinal inflammation
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Influence of cinaciguat on gastrointestinal motility in apo-sGC mice
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Phosphodiesterase 4 interacts with the 5-HT4(b) receptor to regulate cAMP signaling
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Synthesis of 1-substituted epibatidine analogues and their in vitro and in vivo evaluation as α₄β₂ nicotinic acetylcholine receptor ligands
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Sources of ROS during TNF-alpha-induced oxidative stress in murine intestinal epithelial mode-K cells
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Effect of exogenous nitrite in postoperative ileus
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Investigation of 5-HT4 receptors in bronchial hyperresponsiveness in cigarette smoke-exposed mice
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Effect of exogenous nitrite in postoperative ileus
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Cinaciguat in the gastrointestinal tract of apo-sGC mice
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- Journal Article
- A1
- open access
Influence of phosphodiesterases and cGMP on cAMP generation and on phosphorylation of phospholamban and troponin I by 5-HT4 receptor activation in porcine left atrium
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Heme deficiency of soluble guanylate cyclase induces gastroparesis
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- Journal Article
- A1
- open access
Predominant mucosal expression of 5-HT4(+h) receptor splice variants in pig stomach and colon
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Influence of phosphodiesterases on basal and 5-HT₄ receptor facilitated cholinergic contractility in pig descending colon
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BAY 58-2667 does not improve delayed gastric emptying in APO-SGC mice
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Mitochondrial ROS is involved during TNF-A-INDUCED oxidative stress in intestinal epthelial cells
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The facilitating effect of prucalopride on cholinergic neurotransmission in pig gastric circular muscle is regulated by phosphodiesterase 4
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Influence of CORM-A1 and resveratrol on TNF-a-induced oxidative stress and apoptosis in murine MODE-K intestinal epithelial cells
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Study of the regulation of the inotropic response to 5-HT4 receptor activation via phosphodiesterases and its cross-talk with C-type natriuretic peptide in porcine left atrium
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Mechanism of relaxation and interaction with nitric oxide of the soluble guanylate stimulator BAY 41-2272 in mouse gastric fundus and colon
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- Journal Article
- A1
- open access
TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells
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Influence of CORM-A1 on TNF-alpha-induced oxidative stress and apoptosis in mode-K cells
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Mechanism of action of BAY 41-2272 in gastrointestinal relaxation
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The influence of peptide impurity profiles on functional tissue-organ bath response: the 11-mer peptide INSL6[151-161] case
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Relaxant effect of BAY 41-2272 and BAY 58-2667 in the gastric fundus of apo-sGC mice
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- Journal Article
- A1
- open access
In-vitro acetylcholine release is not a straightforward model to study hippocampal 5-HT4 receptors
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- Conference Paper
- C3
- open access
Relaxant effect of BAY 41-2272 and BAY 58-2667 in the gastrointestinal tract of apo-sGC mice
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Investigation of neurogenic excitatory and inhibitory motor responses and their control by 5-HT4 receptors in circular smooth muscle of pig descending colon
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- Conference Paper
- C3
- open access
Purity profiling and the associated functional effects of a new peptide
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Prucalopride induces transient contraction and facilitates tachykininergic contractions in guinea pig proximal colon
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Influence of 5-HT4 receptor activation on acetylcholine release in human large intestine with endometriosis
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Mechanisms of action of hydrogen sulfide in relaxation of mouse distal colonic smooth muscle
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- Conference Paper
- C3
- open access
Bioactive peptides as potential new drugs: from analytics to tissue bath functionality
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- Conference Paper
- C3
- open access
Chemical quality control of peptide functionality testing in tissue baths
(2010) -
Peroxisome proliferator-activated receptor gamma activation alleviates postoperative ileus in mice by inhibition of Egr-1 expression and its downstream target genes
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- Journal Article
- A1
- open access
Selective desensitization of the 5-HT4 receptor-mediated response in pig atrium but not in stomach
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Myosin light chain phosphatase activation is involved in the hydrogen sulfide-induced relaxation in mouse gastric fundus
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Small intestinal motility in soluble guanylate cyclase α₁ knockout mice
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Water-soluble CO-releasing molecules reduce the development of postoperative ileus via modulation of MAPK/HO-1 signalling and reduction of oxidative stress
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Symposium 'Clinical pharmacology anno 2008': 10th Heymans Memorial Lecture
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Apports diagnostiques et pronostiques du dosage des lactates dans le liquide peritoneal du cheval en colique
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Role of the soluble guanylyl cyclase α1/α2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus
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Determination of the source of increased serotonin (5-HT) concentrations in blood and peritoneal fluid of colic horses with compromised bowel
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Gender-specific hypertension and reaction to NO stimulation in sGC alpha 1-/-mice
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Jejunal cholinergic, nitrergic, and soluble guanylate cyclase activity in postoperative ileus
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Investigation of a possible interaction between the heme oxygenase/biliverdin reductase and nitric oxide synthase pathway in murine gastric fundus and jejunum
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Involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SKCa channels in NANC relaxation of mouse distal colon
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Alternative splicing and exon duplication generates 10 unique porcine 5-HT4 receptor splice variants including a functional homofusion variant
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A novel method for the evaluation of intestinal transit and contractility in mice using fluorescence imaging and spatiotemporal motility mapping
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Is there a role for imatinib in inflammatory bowel disease?
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Contractile effects of 5-hydroxytryptamine (5-HT) in the equine jejunum circular muscle: Functional and immunohistochemical identification of a 5-HT1A-like receptor
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Influence of soluble guanylate cyclase inhibition on inflammation and motility disturbances in DSS-induced colitis
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5-HT4 receptor agonists: similar but not the same
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Determination of lactate concentrations in blood plasma and peritoneal fluid in horses with colic by an Accusport analyzer
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Gastric motility in soluble guanylate cyclase alpha(1) knock-out mice
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Mechanisms of relaxation by carbon monoxide-releasing molecule-2 in murine gastric fundus and jejunum
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Inhibitory purinergic P2 receptor characterisation in rat distal colon
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Role of the tachykinin NK1 receptor in mediating contraction to 5-hydroxytryptamine and antigen in the mouse trachea
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- Conference Paper
- C1
- open access
DETERMINATION OF THE SOURCE OF INCREASED SEROTONIN (5-HT) LEVELS IN BLOOD AND PERITONEAL FLUID OF COLIC HORSES WITH COMPROMISED BOWEL
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Endotoxin dose finding study in a septic shock rat model with echo-doppler
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Porcine left atrial and sinoatrial 5-HT4 receptor-induced responses: fading of the response and influence of development
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Differential effects of 5-hydroxytryptamine(4) receptor agonists at gastric versus cardiac receptors: An operational framework to explain and quantify organ-specific behavior
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Gastro-intestinal motility in horses: A practical overview of the therapeutic use of prokinetic agents
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Contractile response to 5-hydroxytryptamine in the equine jejunum
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Contractile effects of 5-hydroxytryptamine and 5-carboxamidotryptamine in the equine jejunum
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5-HT4 receptors located on cholinergic nerves in human colon circular muscle
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Characterization of 5-HT7-receptor-mediated gastric relaxation in conscious dogs
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Influence of the selective neuronal NO synthase inhibitor ARL 17477 on nitrergic neurotransmission in porcine stomach
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Use of plasma ionized Ca2+ levels and Ca2+ substitution response patterns as prognostic parameters for ileus and survival in colic horses
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- Conference Paper
- C1
- open access
In vitro effects of 5-hydroxytryptamine on the jejunum of Healthy and colic Horses: Characterization of a putative 5-HT1A receptor in the Equine Gut
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Involvement of NO in gastric emptying of semi-solid meal in conscious pigs
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Nitric oxide relaxes circular smooth muscle of rat distal colon through RhoA/Rho-kinase independent Ca2+ desensitisation
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Serotonine: casus incognitus voor het paard
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5-HT7 receptor efficacy distribution throughout the canine stomach