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Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis
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Commentary : Genetic modification through oligonucleotide-mediated mutagenesis : a GMO regulatory challenge?
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Genetically Engineered Lactococcus lactis Secreting Murine IL-10 Modulates the Functions of Bone Marrow-Derived Dendritic Cells in the Presence of LPS
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- Conference Paper
- C3
- open access
Reduced metallothionein expression in colonic Crohn's disease: evidence for a new disease-modifying gene
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Reduced metallothionein expression in colonic Crohn's disease: evidence for it new disease-modifying gene
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Murine trefoil factor 3 does not directly modulate LPS-mediated dendritic cell function
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Alternative method to identify susceptibility genes for Crohn's disease through transcriptome analysis
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Intracellular accumulation of trehalose protects Lactococcus lactis from freeze-drying damage and bile toxicity and increases gastric acid resistance
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Altered gut transcriptome in spondyloarthropathy
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Clinical potential of Lactococcus lactis mediated delivery of human Interleukin-10 and Trefoil Factors
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Formatted anti-tumor necrosis factor alpha VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen-induced arthritis
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A phase I trial with Transgenic bacteria expressing interleukin-10 in Crohn's disease
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Improved periplasmic production of biologically active murine interleukin-2 in Escherichia coli through a single amino acid change at the cleavage site
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- Journal Article
- A1
- open access
CARD15 gene polymorphisms in patients with spondyloarthropathies identify a specific phenotype previously related to Crohn's disease
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Formatted anti-TNF-alpha nanobodies show superior efficacy in a collagen-induced arthritis model in mice
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Development of an enteric-coated, layered multi-particulate formulation for ileal delivery of viable recombinant Lactococcus lactis
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Development of an enteric-coated formulation containing freeze-dried, viable recombinant Lactococcus lactis for the ileal mucosal delivery of human interleukin-10
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CARD15 polymorphisms are associated with anti-Saccharomyces cerevisiae antibodies in caucasian Crohn's disease patients
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Evaluation of extrusion/spheronisation, layering and compaction for the preparation of an oral, multi-particulate formulation of viable, hIL-10 producing Lactococcus lactis
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Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice