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- open access
Scientific innovation for the sustainable development of African agriculture
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- Miscellaneous
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On the prevention of konzo, lessons learned from neurolathyrism
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- Journal Article
- A1
- open access
Grass pea (Lathyrus sativus L.) : orphan crop, nutraceutical or just plain food?
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- Miscellaneous
- open access
Is grass pea (Lathyrus sativus L.) taking the stage in a world with changing climate?
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- Miscellaneous
- open access
Editorial
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- Journal Article
- A4
- open access
Remembering Vapniarca (Sept. 1942-May 1943), doctor Kessler (1903-2000), Professor dr Dan Cohn (1931-2017)
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- Journal Article
- A1
- open access
Plant toxin β-ODAP activates integrin β1 and focal adhesion : a critical pathway to cause neurolathyrism
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- Miscellaneous
- open access
Beyond the Millenium Development Goals: new agenda
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- Journal Article
- A4
- open access
Is stress a factor in the susceptibility to neurolathyrism?
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- Miscellaneous
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Editorial
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- Journal Article
- A4
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Lathyrus sativus L. (grass pea) toxic plant or nutraceutical?
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- Miscellaneous
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Editorial
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- Journal Article
- A4
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Crippling konzo in DRC, three generations later
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- Conference Paper
- C3
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Experimental model of neurolathyrism : role of heme oxygenase-1 in the vascular insult associated with hind-leg paraparesis
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- Journal Article
- A4
- open access
Lathyrus sativus: to eat or not to eat?
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Is chronic exposure of the blood-brain barrier to relatively low L-β-ODAP concentrations a possible entry point of L-β-ODAP into the central nervous system?
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Lathyrus sativus: from royal funeral offering to toxic plant to wonder crop?
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Vascular insult accompanied by overexpressed heme oxygenase-1 as a pathophysiological mechanism in experimental neurolathyrism with hind-leg paraparesis
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- Journal Article
- A1
- open access
Research on motor neuron diseases konzo and neurolathyrism : trends from 1990 to 2010
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- Journal Article
- A4
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On the molecular mechanisms of konzo and neurolathyrism
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- Book Chapter
- open access
Soya, human nutrition and health
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- Journal Article
- A4
- open access
Neurolathyrism in Ethiopia: preliminary data
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L-β-N-oxalyl-α,β-diaminopropionic acid toxicity in motor neurons
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Studies on neurolathyrism in Ethiopia: dietary habits, perception of risk and prevention
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Climatic, edaphic and altitudinal factors affecting yield and toxicity of Lathyrus sativus grown at five locations in Ethiopia
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Effect of environmental factors on the biosynthesis of the neuro-excitatory amino acid beta-ODAP (beta-N-oxalyl-L-alpha, beta-diaminopropionic acid) in callus tissue of lathyrus sativus
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Sulfur amino acids deficiency caused by grass pea diet plays an important role in the toxicity of L-beta-ODAP by increasing the oxidative stress: studies on a motor neuron cell line
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Konzo and dietary pattern in cassava-consuming populations of Popokabaka, democratic republic of Congo
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Konzo and neurolathyrism: similarities and dissimilarities between these crippling neurodegenerative diseases of the poor
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Unraveling the mechanism of β-N-oxalyl-α,β-diaminopropionic acid (β-ODAP) induced excitotoxicity and oxidative stress, relevance for neurolathyrism prevention
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- Journal Article
- A4
- open access
Why are neurolathyrism and konzo neglected diseases?
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- Journal Article
- A4
- open access
Can we meet the first Millenium Development Goal in konzo and lathyrism settings by 2015?
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- Conference Paper
- C3
- open access
Lathyrus sativus and human health
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- Journal Article
- A4
- open access
Progress in prevention of toxico-nutritional neurodegenerations
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Effect of methionine supplement on physical responses and neurological symptoms in broiler chicks fed grass pea (Lathyrus sativus)-based starter ration
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Hind-limb paraparesis in a rat model for neurolathyrism associated with apoptosis and an impaired vascular endothelial growth factor system in the spinal cord
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L-β-ODAP alters mitochondrial Ca2+ handling as an early event in excitotoxicity
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Lathyrism
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- Miscellaneous
- open access
The Lathyrus/lathyrism controversy
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Neuro- and gliotoxicity of the excitatory amino acid beta-ODAP involves impaired free radical defence
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Preliminary attempts in molecular breeding of Ethiopian grass pea (Lathyrus sativus L.): productive regeneration and genetic transformation
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Unraveling the mechanism of beta-ODAP induced excitotoxicity and oxidative stress, relevance for neurolathyrism prevention
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Is lathyrism still endemic in northern Ethiopia? : the case of Legambo Woreda (district) in the South Wollo Zone, Amhara National Regional State
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An improved neurolathyrism rat model : impaired VEGF systems have a critical role in the degeneration of motor neurons
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Effect of agro-ecological factors on the accumulation of neurotoxin and other amino acids in Lathyrus sativus
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Study on climatic, edaphic and altitudinal factors affecting yield and toxicity of grass pea grown in Ethiopia
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Konzo and dietary pattern in cassava-consuming populations of Popokabaka, Democratic Republic of Congo
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Workshop on toxico-nutritional neurodegenerations konzo and lathyrism: foreword
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- Book Editor
- open access
Workshop on toxico-nutritional neurodegenerations konzo and lathyrism
(2009) 14. -
Neuro- and gliotoxicity of the excitatory amino acid beta-ODAP involves impaired free radical difference
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- Conference Paper
- C1
- open access
Grain legumes and human health
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Nutritional improvement of grass pea and cassava to prevent neurolathyrism and konzo
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The contents of the neuro-excitatory amino acid beta-ODAP (beta-N-oxalyl-L-alpha,beta-diaminopropionic acid), and other free and protein amino acids in the seeds of different genotypes of grass pea (Lathyrus sativus L.)
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- Journal Article
- A1
- open access
3-N-oxalyl-L-2,3-diaminopropanoic acid, a multifunctional plant metabolite of toxic reputation
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Comparison of urinary amino acids and trace elements (copper, zinc and manganese) of recent neurolathyrism patients and healthy controls from Ethiopia
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Quantitative analysis of the motor neuron death in the neurolathyrism model rat
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Kinetics of free protein amino acids, free non-protein amino acids and trigonelline in soybean (Glycine max L.) and lupin (Lupinus angustifolius L.) sprouts
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Lathyrus improvement for resistance against biotic and abiotic stresses: From classical breeding to marker assisted selection
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Is lathyrism still endemic in northern Ethiopia?: the case of the Legambo Woreda (district) in the South Wollo Zone, Amhara National Regional State
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Neurolathyrism risk depends on type of grass pea preparation and on mixing with cereals and antioxidants
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Development of a model rat of the motor neuron death
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Effects of different germination conditions on the contents of free protein and non-protein amino acids of commercial legumes
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Partial involvement of group I metabotropic glutamate receptors in the neurotoxicity of 3-N-oxalyl-L-2,3-diaminopropanoic acid (L-beta-ODAP)
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- Journal Article
- A4
- open access
Cassava leaves, a non negligible source of dietary exposure to cyanogens
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Neuroactive and other free amino acids in seed and young plants of Panax ginseng
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Amino acid profiles and protein quality of cooked cassava leaves or 'saka-saka'
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Cassava cyanogens and free amino acids in raw and cooked leaves
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Food-aid cereals to reduce neurolathyrism related to grass-pea preparations during famine
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Neurolathyrism in Ethiopia: assessment and comparison of knowledge and attitude of health workers and rural inhabitants
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ABO blood groups, grass pea preparation, and neurolathyrism in Ethiopia
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Pattern and associated factors of the neurolathyrism epidemic in Ethiopia.
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Mechanism of ODAP oxicity in one-day-old chicks.
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Food safety and amino acid balance in processed cassava 'Cossettes'
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Prolific regeneration of fertile plants from green nodular callus induced from meristematic tissues in Lathyrus sativus L. (grass pea)
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New functional foods by germination: Effect on the nutritive value of beans, lentils and peas.
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Non-protein amino acids and food safety
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Non-protein amino acids in edible lentil and garden pea seedlings.
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Identification and quantification of natural isoxazolinone compounds by capillary zone electrophoresis.
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Amino acids in seeds and seedlings of the genus Lens.
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Reduction efficiency of the neurotoxin beta-ODAP in low-toxin varieties of Lathyrus sativus seeds by solid state fermentation with Aspergillus oryzae and Rhizopus microsporus var chinensis.
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Free amino acids present in commercially available seedlings sold for human consumption. A potential hazard for consumers.
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Enzymatic formation of 2,3-diaminopropionic acid, the direct precursor of the neurotoxin beta-ODAP, in Lathyrus sativus.
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Epidemic of neurolathyrism in Ethiopia.
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Metabolic routes of beta-(isoxazolin-5-on-2-yl)-L-alanine (BIA), the precursor of the neurotoxin ODAP (beta-N-oxalyl-L-alpha,beta,-diaminopropionic acid), in different legume seedlings.
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Chemotaxonomy based on non protein amino acids applied to questions of authenticity of food
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Lathyrus and lathyrism: a Decade of Progress: proceedings of an international conference.
(1997) -
Evidence of Osteolathyrism among patients suffering from Neurolathyrism in Bangladesh.
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Serum zinc levels in lathyrism patients.
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Is ß-ODAP the only cause for human neurolathyrism?
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Lathyrus sativus, a neolithic crop with a modern future?: an overview of the present situation.
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Mechanism of ODAP toxicity in one-day-old chicks.
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Inhibitory activity of a naturally occurring heterocyclic beta-substituted alanine, beta-(isoxazolin-5-on-4-yl)-L-alanine, on the L-glutamate/L-aspartate transporter (GLAST) expressed in Xenopus oocytes.
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Symptomatic treatment of neurolathyrism with Tolperisone.HCL (Mydocalm): a randomized double blind and placebo controlled drug trial.
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Salinity tolerance and accumulation of neurotoxin and excitatory amino acids in Lathyrus sativus
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Effects of beta-ODAP and its biosynthetic precursor on the electrophysiological activity of cloned glutamate receptors.
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Epidemiological study of lathyrism in northwestern districts of Bangladesh.
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Enzymatic synthesis of two isoxazolylalanine isomers by cysteine synthases in Lathyrus species.
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Lathyrus sativus and human lathyrism: progress and prospects from international collaborators: proceedings of the Second International Colloquium on Lathyrus/Lathyrism, Dhaka, December 10-12, 1993
(1995) -
Study of some socio-economic aspects of lathyhrism patients in two northwestern districts of Bangladesh
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Biosynthesis in vitro of some Lathyrus toxins
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Influence of nutrient status for cultivation of Lathyrus sativus and level of the neurotoxin ODAP: a link between environment and toxicity?
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High-performance liquid chromatographic separation of the toxins and some non-protein amino acids in Lathyrus sativus
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Neurotransmitters in the cerebrospinal fluid and serum of neurolathyrism patients
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Biosynthesis in vivo of the neurotoxin ß-ODAP in Lathyrus sativus
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Biosynthesis of the neurotoxin ß-ODAP in callus tissue of Lathyrus sativus, incorporation of [^N]- and ['^CJ-precursors
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Detoxification of Lathyrus sativus meal by fermentation without loss of nutritive value
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Collaborative projects on Lathyrus and human lathyrism coordinated by the University of Ghent, Belgium: prospects for further research
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In vitro Toxicological Investigations of Isoxazolinone Amino Acids of Lathyrus sativus
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Progress and Prospects in the Bangladesh/Belgium Inter-university project.
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Homoarginine antagonizes the toxicity of Lathyrus toxin in 1-day-old-chicks.
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Inhibitory and excitatory amino-acids in cerebrospinal-fluid of neurolathyrism patients, a highly prevalent motorneurone disease.
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STUDY OF HTLV-I ANTIBODIES IN CSF AND SERUM OF NEUROLATHYRISM PATIENTS IN BANGLADESH.
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SOLID-STATE FERMENTATION OF LATHYRUS-SATIVUS SEEDS USING ASPERGILLUS-ORYZAE AND RHIZOPUS-OLIGOSPORUS SP T-3 TO ELIMINATE THE NEUROTOXIN BETA-ODAP WITHOUT LOSS OF NUTRITIONAL-VALUE.
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Interaction of some heterocyclic beta-substituted alanines of plants with rat-brain N-METHYL-D-ASPARTATE (NMDA) receptors.
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Conformation of the Lathyrus neurotoxin ß-ODAP and its neurochemical implications
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Recent progress in the Bangladesh-Belgium inter-university project
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Appearance of the neurotoxinß-N-oxalyl-L-oc.ß-diaminopropionic acid (ß-ODAP) and of homoarginine in systemic blood and urine following the consumption of cooked Lathyrus sativus by human volunteers
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Thermal isomerization of N-oxalyl derivatives of diamino acids
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Study of Lathyrism: some new findings
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Reduction of the neurotoxin ODAP from Lathyrus sativus meal by double fermentation
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Biochemical diversity in the genus Lathyrus
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New findings and symptomatic treatment for neurolathyrism, a motor neuron disease occuring in North West Bangladesh
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The mechanism of the rearrangement of the neurotoxin β-ODAP to α-ODAP
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Ring-nitrogen of beta-isoxazolinone-alanine is incorporated into the neurotoxin, beta-N-oxalyl-L-a, beta-diaminopropionic acid, in callus tissue of Lathyrus-sativus.
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Biosynthesis of the neurotoxin-beta-ODAP in developing pods of Lathyrus sativus.
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From soil to brain: zinc deficiency increases the neurotoxicity of Lathyrus sativus and may affect the susceptibility for the motorneurone disease neurolathyrism.
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Determination of non-protein amino acids and toxins in Lathyrus sativus by high-performance liquid chromatography with precolumn phenyl isothiocyanate derivatisation.
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Chemistry of grass pea toxin and related N-oxalyl amino acids
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Toxins in the seedlings of some varieties of grass pea (Lathyrus sativus)
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Chemical properties of the natural neurotoxin of Lathyrus sativus 3-N-oxalyl-2,3-diamino-propanoic acid (β-ODAP), its nontoxic 2-N-oxalyl isomer, and its hydrolysis product 2,3-diamino-propanoic acid (DAPRO) by 1H- and 13C-NMR spectroscopy
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Analysis of the neurotoxin β-ODAP and its α-isomer by precolumn derivatization with phenylisothiocyanate
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Thermal isomerization of N-oxalyl derivatives of diamino acids
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Biosynthesis in vitro of 2-(3-amino-3-carboxy-propyl)-isoxazolin-5-one, the neurotoxic amino acid in Lathyrus odoratus.
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Biosynthesis of beta-(isoxazolin-5-on-2-yl)-L-alanine by cysteine synthase in Lathyrus sativus.
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Metabolism of ß-(isoxazolin-5-on-2-yl)-alanine to the neurotoxin ODAP in callus tissue of Lathyrus sativus
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Toxic non-coding amino acids in the genus Lathyrus
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Purification and some properties of cysteine synthases from Lathyrus sativus
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Chemistry of natural occurring isoxazolin-5-ones
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Beta-isoxazolinone-alanine and lathyrism research: optimisation of its isolation and purification
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The biosynthesis of the Lathyrus toxins
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Recent developments in the biochemistry of the Lathyrus toxins
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Characterization of γ-glutamyl-β-(isoxazolinonyl)-alanine from Lathyrus sativus and its decarboxylation product from Lathyrus odoratus
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Identification of new isoxazolinone derivatives in lathyrus species by 1H and 13C NMR.
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Mechanism for the photolysis of the naturally occuring isoxazolin-5-ones and the link with the Lathyrus toxins
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Free amino acids and toxins in Lathyrus-sativus seedlings.
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Semipreparative isolation of individual cyanobacterial heterocyst type glycolipids by reverse-phase high-performance liquid chromatography.
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Quantitative derivatization and high-performance liquid chromatographic analysis of cyanobacterial heterocyst-type glycolipids.
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Recent development in the biochemistry of the Lathyrus toxins
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Biosynthesis of the neurotoxin beta-N-oxalyl-alpha,beta-diaminopropionic acid in callus tissue of Lathyrus sativus.
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1H and 13C NMR data for the basic naturally occurring isoxazolin-5-one derivatives
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Biosynthesis of beta-(isoxazolin-5-on-2-yl)alanine, the precursor of the neurotic amino-acid beta-N-oxalyl-L-alpha,beta-diaminopropionic acid.