dr. Yong Chen

Journal Article
A1
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Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo

Yong Chen (UGent) , Emily De Lombaerde, Aimee-Rose Bugler-Lamb (UGent) , Zifu Zhong (UGent) , Martijn Schuijs (UGent) , Claudia Mariela Brenis Gómez (UGent) , Jamie De Baere (UGent) , Mark Gontsarik (UGent) , Heleen Lauwers (UGent) , Kim Deswarte (UGent) , et al.

(2025) ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 64(28).

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A f entanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity

Zifu Zhong (UGent) , Marie Deventer (UGent) , Yong Chen (UGent) , Stijn Vanhee (UGent) , Inés Lammens (UGent) , Kim Deswarte (UGent) , Yi Huang (UGent) , Tingting Ye (UGent) , Haixiu Wang (UGent) , Lutz Nuhn, et al.

(2025) ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 64(7).

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HER2 nanobody-poly(rhamnose) conjugates efficiently recruit anti-rhamnose antibodies from serum to the surface of HER2-expressing cells

Weiwei Mu (UGent) , Yong Chen (UGent) , Zifu Zhong (UGent) , Benoit Louage (UGent) , Heleen Lauwers (UGent) , Nick Devoogdt, Jurgen Haustraete (UGent) and Bruno De Geest (UGent)

(2024) CHEMISTRY OF MATERIALS. 36(20). p.10113-10124

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CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

Tingting Ye (UGent) , Zifu Zhong (UGent) , Federica Cappellesso, Kim Deswarte (UGent) , Yong Chen (UGent) , Heleen Lauwers (UGent) , Emily De Lombaerde (UGent) , Mark Gontsarik (UGent) , Stefan Lienenklaus, Dorien Van Lysebetten, et al.

(2024) BIOMATERIALS. 311.

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Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation

Emily De Lombaerde (UGent) , Xiaole Cui (UGent) , Yong Chen (UGent) , Zifu Zhong (UGent) , Julie Deckers (UGent) , Giulia Mencarelli, Lisa Opsomer (UGent) , Haixiu Wang (UGent) , Jamie De Baere (UGent) , Stefan Lienenklaus, et al.

(2024) ACS NANO. 18(41). p.28311-28324

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Lysosomal trafficking and degradation of extracellular proteins via multivalent small molecule ligand display on dextran scaffolds

Benoit Louage (UGent) , Demi Defreyne (UGent) , Heleen Lauwers (UGent) , Jamie De Baere (UGent) , Annemiek Uvyn (UGent) , Haixia Peng (UGent) , Yong Chen (UGent) and Bruno De Geest (UGent)

(2024) BIOMACROMOLECULES. 26(1). p.738-750

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Dual-ligand PROTACS mediate superior target protein degradation in vitro and therapeutic efficacy in vivo

Yong Chen (UGent) , Zihan Xia (UGent) , Ujjwal Suwal, Pekka Rappu, Jyrki Heino, Olivier De Wever (UGent) and Bruno De Geest (UGent)

(2024) CHEMICAL SCIENCE. 15(42). p.17691-17701

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Lipid nanoparticle composition for adjuvant formulation modulates disease after influenza virus infection in quadrivalent influenza vaccine vaccinated mice

Sonia Jangra, Alexander Lamoot, Gagandeep Singh, Gabriel Laghlali (UGent) , Yong Chen (UGent) , Tingting Ye (UGent) , Adolfo García-Sastre, Bruno De Geest (UGent) and Michael Schotsaert

(2024) FRONTIERS IN IMMUNOLOGY. 15.

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Combinatorial screening of biscarbamate ionizable lipids identifies a low reactogenicity lipid for lipid nanoparticle mRNA delivery

Emily De Lombaerde (UGent) , Yong Chen (UGent) , Tingting Ye (UGent) , Julie Deckers (UGent) , Giulia Mencarelli, Kim Deswarte (UGent) , Heleen Lauwers (UGent) , Ruben De Coen (UGent) , Sabah Kasmi (UGent) , Sanne Bevers, et al.

(2024) ADVANCED FUNCTIONAL MATERIALS. 34(21). p.1-16

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Lipid nanoparticle encapsulation empowers poly(I:C) to activate cytoplasmic RLRs and thereby increases its adjuvanticity

Alexander Lamoot, Sonia Jangra, Gabriel Laghlali, Prajakta Warang, Gagandeep Singh, Lauren A. Chang, Seok‐Chan Park, Gagandeep Singh, Kim Deswarte (UGent) , Zifu Zhong (UGent) , et al.

(2024) SMALL. 20(10).

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dr. Yong Chen

Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo

A f entanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity

HER2 nanobody-poly(rhamnose) conjugates efficiently recruit anti-rhamnose antibodies from serum to the surface of HER2-expressing cells

CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation

Lysosomal trafficking and degradation of extracellular proteins via multivalent small molecule ligand display on dextran scaffolds

Dual-ligand PROTACS mediate superior target protein degradation in vitro and therapeutic efficacy in vivo

Lipid nanoparticle composition for adjuvant formulation modulates disease after influenza virus infection in quadrivalent influenza vaccine vaccinated mice

Combinatorial screening of biscarbamate ionizable lipids identifies a low reactogenicity lipid for lipid nanoparticle mRNA delivery

Lipid nanoparticle encapsulation empowers poly(I:C) to activate cytoplasmic RLRs and thereby increases its adjuvanticity

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