Sarah-Lee Bekaert

Journal Article
A1
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Second-generation AURKA-targeting PROTACs : structural optimization toward in vivo degradation in neuroblastoma

Simon Krols (UGent) , Muhammad Rishfi (UGent) , Fien Martens (UGent) , Anouk Van Hauwermeiren (UGent) , Ellen Sanders (UGent) , Pieter-Jan De Sutter (UGent) , An Vermeulen (UGent) , Kaat De Wever (UGent) , Sarah-Lee Bekaert (UGent) , M. Emmy M. Dolman, et al.

(2025) JOURNAL OF MEDICINAL CHEMISTRY. 68(22). p.23962-23976

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A1
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Synergistic inhibition of CHK1 and MUS81 to combat replication stress resistance in high-risk neuroblastoma

Elien Hilgert (UGent) , Christophe Van Neste (UGent) , Sarah-Lee Bekaert (UGent) , Fien Martens (UGent) , Suzanne Vanhauwaert (UGent) , Ellen Sanders (UGent) , Peter Verstraelen, Martijn Risseeuw (UGent) , Ellen M. Westerhout, Mark A. Grannetia, et al.

(2025) SCIENTIFIC REPORTS.

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NBAtlas : a harmonized single-cell transcriptomic reference atlas of human neuroblastoma tumors

Noah Bonine (UGent) , Vittorio Zanzani (UGent) , Annelies Van Hemelryk (UGent) , Bavo Vanneste (UGent) , Christian Zwicker (UGent) , Tinne Thoné (UGent) , Sofie Roelandt (UGent) , Sarah-Lee Bekaert (UGent) , Jan Koster, Isabelle Janoueix-Lerosey, et al.

(2024) CELL REPORTS. 43(10).

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Human iPSC modeling recapitulates in vivo sympathoadrenal development and reveals an aberrant developmental subpopulation in familial neuroblastoma

Stéphane Van Haver, Yujie Fan, Sarah-Lee Bekaert (UGent) , Celine Everaert (UGent) , Wouter Van Loocke (UGent) , Vittorio Zanzani (UGent) , Joke Deschildre, Ines Fernandez Maestre, Adrianna Amaro, Vanessa Vermeirssen (UGent) , et al.

(2024) ISCIENCE. 27(1).

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Preclinical exploration of the DNA damage response pathway using the interactive neuroblastoma cell line explorer CLEAN

Jonatan Linus Gabre (UGent) , Peter Merseburger (UGent) , Arne Claeys (UGent) , Joachim Siaw (UGent) , Sarah-Lee Bekaert (UGent) , Franki Speleman (UGent) , Bengt Hallberg, Ruth H Palmer and Jimmy Van den Eynden (UGent)

(2024) NAR CANCER. 6(1).

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Miscellaneous

Preclinical exploration of the DNA Damage Response pathway using the interactive neuroblastoma cell line explorer CLEAN

Jonatan Linus Gabre (UGent) , Peter Merseburger (UGent) , Arne Claeys (UGent) , Joachim Siaw (UGent) , Sarah-Lee Bekaert (UGent) , Franki Speleman (UGent) , Bengt Hallberg, Ruth H. Palmer and Jimmy Van den Eynden (UGent)

(2023) bioRxiv.

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Post‐operative minimal residual disease models to study metastatic relapse in soft‐tissue sarcoma patient‐derived xenografts

Suzanne Fischer (UGent) , David Creytens (UGent) , Sofie De Geyter (UGent) , Elly De Vlieghere (UGent) , Piet Pattyn (UGent) , Sarah-Lee Bekaert (UGent) , Kaat Durinck (UGent) , Nadine Van Roy (UGent) , An Hendrix (UGent) , Lore Lapeire (UGent) , et al.

(2023) CLINICAL AND TRANSLATIONAL MEDICINE. 13(6).

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SOX11 is a mediator of core regulatory circuit robustness : upregulation of SWI/SNF components and recruitment of transcriptional enhancer NONO

Amber Louwagie, Bieke Decaesteker (UGent) , Sarah-Lee Bekaert (UGent) , Fanny De Vloed (UGent) , Ellen Sanders (UGent) , Stéphane Van Haver, Tim Pieters (UGent) , Pieter Van Vlierberghe (UGent) , S Roberts, S Ek, et al.

(2023) Advances in Neuroblastoma Research (ANR) Meeting 2023, Abstracts. p.31-31

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SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry

Bieke Decaesteker (UGent) , Amber Louwagie, Siebe Loontiens (UGent) , Fanny De Vloed (UGent) , Sarah-Lee Bekaert (UGent) , Juliette Roels (UGent) , Suzanne Vanhauwaert (UGent) , Sara De Brouwer (UGent) , Ellen Sanders, A Berezovskaya, et al.

(2023) NATURE COMMUNICATIONS. 14(1).

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Targeted AURKA degradation : towards new therapeutic agents for neuroblastoma

Muhammad Rishfi (UGent) , Simon Krols (UGent) , Fien Martens (UGent) , Sarah-Lee Bekaert (UGent) , Ellen Sanders (UGent) , Aline Eggermont (UGent) , Fanny De Vloed (UGent) , Joshua Robert Goulding (UGent) , Martijn Risseeuw (UGent) , Jan Molenaar, et al.

(2023) EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 247.

Academic Bibliography

Sarah-Lee Bekaert

Second-generation AURKA-targeting PROTACs : structural optimization toward in vivo degradation in neuroblastoma

Synergistic inhibition of CHK1 and MUS81 to combat replication stress resistance in high-risk neuroblastoma

NBAtlas : a harmonized single-cell transcriptomic reference atlas of human neuroblastoma tumors

Human iPSC modeling recapitulates in vivo sympathoadrenal development and reveals an aberrant developmental subpopulation in familial neuroblastoma

Preclinical exploration of the DNA damage response pathway using the interactive neuroblastoma cell line explorer CLEAN

Preclinical exploration of the DNA Damage Response pathway using the interactive neuroblastoma cell line explorer CLEAN

Post‐operative minimal residual disease models to study metastatic relapse in soft‐tissue sarcoma patient‐derived xenografts

SOX11 is a mediator of core regulatory circuit robustness : upregulation of SWI/SNF components and recruitment of transcriptional enhancer NONO

SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry

Targeted AURKA degradation : towards new therapeutic agents for neuroblastoma

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