dr. Tineke Vanderhaeghen

Journal Article
A1
open access

A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

Céline Van Dender (UGent) , Steven Timmermans (UGent) , Ville Paakinaho, Tineke Vanderhaeghen (UGent) , Jolien Vandewalle (UGent) , Maarten Claes (UGent) , Bruno Garcia, Bart Roman (UGent) , Jan De Waele (UGent) , Siska Croubels (UGent) , et al.

(2024) EMBO MOLECULAR MEDICINE.

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Journal Article
A2
open access

Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in metabolic dysfunction associated Steatotic liver disease (MASLD)

Claudia Theys, Tineke Vanderhaeghen (UGent) , Evelien Van Dijck, Cedric Peleman, Anne Scheepers, Joe Ibrahim, Ligia Mateiu, Steven Timmermans (UGent) , Tom Vanden Berghe (UGent) , Sven M. Francque, et al.

(2024) FRONTIERS IN MOLECULAR MEDICINE. 3.

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Journal Article
A1
open access

Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression

Sofie Desmet, Jonathan Thommis (UGent) , Tineke Vanderhaeghen (UGent) , Edmee Vandenboorn (UGent) , Dorien Clarisse (UGent) , Yunkun Li, Steven Timmermans (UGent) , Daria Fijalkowska (UGent) , Dariusz Ratman (UGent) , Evelien Van Hamme (UGent) , et al.

(2024) MOLECULAR METABOLISM. 84.

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The pig as a translational animal model to explore a new concept in the treatment of sepsis, today's largest unmet medical need

Fëllanza Halimi (UGent) , Charlotte Cuypers (UGent) , Bruna Alonso (UGent) , Eline Hermans (UGent) , Diethard Reckelbus (UGent) , Jolien Vandewalle (UGent) , B. Garcia, A. Herpain, Tineke Vanderhaeghen (UGent) , Céline Van Dender (UGent) , et al.

(2023) JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS. 46(Supplement 1). p.33-34

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Journal Article
A1
open access

The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function

Tineke Vanderhaeghen (UGent) , Steven Timmermans (UGent) , Melanie Eggermont (UGent) , Deepika Watts, Jolien Vandewalle (UGent) , Charlotte Wallaeys (UGent) , Louise Nuyttens (UGent) , Joyca De Temmerman (UGent) , Tino Hochepied (UGent) , Sylviane Dewaele (UGent) , et al.

(2023) FRONTIERS IN IMMUNOLOGY. 14.

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Miscellaneous

Spns2/S1P : it takes two to tango with inflammation and metabolic rewiring during sepsis

Tineke Vanderhaeghen (UGent) , Jolien Vandewalle (UGent) and Claude Libert (UGent)

(2023) EMBO REPORTS. 24(8).

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Journal Article
A1
open access

Hepatic peroxisome proliferator-activated receptor alpha dysfunction in porcine septic shock

Jolien Vandewalle (UGent) , Bruno Garcia, Steven Timmermans (UGent) , Tineke Vanderhaeghen (UGent) , Lise Van Wyngene, Melanie Eggermont (UGent) , Hester Dufoor (UGent) , Céline Van Dender (UGent) , Fëllanza Halimi (UGent) , Siska Croubels (UGent) , et al.

(2022) CELLS. 11(24).

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Journal Article
A1
open access

Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding

Steven Timmermans (UGent) , Nicolette J.D. Verhoog, Kelly Van Looveren, Sylviane Dewaele (UGent) , Tino Hochepied (UGent) , Melanie Eggermont (UGent) , Barbara Gilbert (UGent) , Anne Boerema-de Munck, Tineke Vanderhaeghen (UGent) , Joke Vanden Berghe (UGent) , et al.

(2022) JOURNAL OF BIOLOGICAL CHEMISTRY. 298(2).

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Reprogramming of glucocorticoid receptor function by hypoxia

Tineke Vanderhaeghen (UGent) , Steven Timmermans (UGent) , Deepika Watts, Ville Paakinaho, Melanie Eggermont (UGent) , Jolien Vandewalle (UGent) , Charlotte Wallaeys (UGent) , Lise Van Wyngene, Kelly Van Looveren, Louise Nuyttens (UGent) , et al.

(2022) EMBO REPORTS. 23(1).

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PhD Thesis

The effect of hypoxia and hypoxia inducible factors on the glucocorticoid receptor function and their role during sepsis

Tineke Vanderhaeghen (UGent)

(2021)

Academic Bibliography

dr. Tineke Vanderhaeghen

A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in metabolic dysfunction associated Steatotic liver disease (MASLD)

Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression

The pig as a translational animal model to explore a new concept in the treatment of sepsis, today's largest unmet medical need

The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function

Spns2/S1P : it takes two to tango with inflammation and metabolic rewiring during sepsis

Hepatic peroxisome proliferator-activated receptor alpha dysfunction in porcine septic shock

Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding

Reprogramming of glucocorticoid receptor function by hypoxia

The effect of hypoxia and hypoxia inducible factors on the glucocorticoid receptor function and their role during sepsis

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