Zifu Zhong

Multivalent antibody-recruiters targeting fibroblast activation protein for innate immune killing

Weiwei Mu (UGent) , Yong Chen (UGent) , Zifu Zhong (UGent) , Jamie De Baere (UGent) , Heleen Lauwers (UGent) , Demi Defreyne (UGent) , Haixia Peng, Bruno De Geest (UGent) and Benoit Louage (UGent)

(2026) BIOMACROMOLECULES. 27(6). p.4026-4037

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Impact of pre-existing anti-replicase immunity on the efficacy of self-amplifying mRNA vaccines

Xiaole Cui (UGent) , Laura Amelinck (UGent) , Oriane Gillon (UGent) , João Paulo Portela Catani, Ya Gao (UGent) , Qing Sun (UGent) , Elisabeth De Sutter (UGent) , Pieter Vervaeke (UGent) , Janne Snoeck (UGent) , Stefan Lienenklaus, et al.

(2025) NATURE COMMUNICATIONS. 17(1).

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Cyclic poly(2-methyl-2-oxazoline)-lipid conjugates are good alternatives to poly(ethylene glycol)-lipids for lipid nanoparticle mRNA formulation

Bianka Golba, Zifu Zhong (UGent) , Matteo Romio, Ruben Almey (UGent) , Dieter Deforce (UGent) , Maarten Dhaenens (UGent) , Niek Sanders (UGent) , Edmondo M. Benetti and Bruno De Geest (UGent)

(2025) BIOMACROMOLECULES. 26(3). p.1816-1825

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Admixing of mRNA with pre‐formed lipid nanoparticles containing a slightly‐cationic ionizable lipid allows for efficient mRNA transfection in vitro and in vivo

Haixiu Wang, Heleen Lauwers (UGent) , Mark Gontsarik (UGent) , Yong Chen (UGent) , Niek Sanders (UGent) , Miffy Hok Yan Cheng, Bruno De Geest (UGent) and Zifu Zhong (UGent)

(2025) ADVANCED HEALTHCARE MATERIALS. 14(23).

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Combinatorial synthesis and evaluation of trialkyl galloyl amidoamine ionizable lipids for mRNA formulation

Bianka Golba, Irene De Franceschi (UGent) , Zifu Zhong (UGent) , Martijn Schuijs (UGent) , Claudia Mariela Brenis Gómez (UGent) , Heleen Lauwers (UGent) , Benoit Louage (UGent) , Iasona Sheshi (UGent) , Nezha Badi (UGent) , Bruno De Geest (UGent) , et al.

(2025) JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 147(30). p.26934-26943

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Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo

Yong Chen (UGent) , Emily De Lombaerde, Aimee-Rose Bugler-Lamb (UGent) , Zifu Zhong (UGent) , Martijn Schuijs (UGent) , Claudia Mariela Brenis Gómez (UGent) , Jamie De Baere (UGent) , Mark Gontsarik (UGent) , Heleen Lauwers (UGent) , Kim Deswarte (UGent) , et al.

(2025) ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 64(28).

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Enhancing anti-tumor immunity through intratumoral combination therapy with amphiphilic conjugates of oxaliplatin and imidazoquinoline TLR7/8 agonist

Hanne Verschuere (UGent) , Sabah Kasmi (UGent) , Lutz Nuhn (UGent) , Sènan Mickaël D'Almeida, Qiwen Zhu, Zifu Zhong (UGent) , Sandy Adjemian Catani (UGent) , Benoit Louage (UGent) , Jana De Vrieze, Haijun Yu, et al.

(2025) RSC ADVANCES. 15(15). p.11662-11674

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A genetically encoded endogenous antibody recruitment strategy for innate immune-mediated killing of cancer cells

Justine Aelvoet (UGent) , Zifu Zhong (UGent) , Claudia Mariela Brenis Gómez (UGent) , Helena Catharine Aegerter (UGent) , Benoit Louage (UGent) , Bart Lambrecht (UGent) , Bruno De Geest (UGent) and Martijn Schuijs (UGent)

(2025) ADVANCED MATERIALS. 37(11).

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A fentanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity

Zifu Zhong (UGent) , Marie Deventer (UGent) , Yong Chen (UGent) , Stijn Vanhee (UGent) , Inés Lammens (UGent) , Kim Deswarte (UGent) , Yi Huang (UGent) , Tingting Ye, Haixiu Wang, Lutz Nuhn (UGent) , et al.

(2025) ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 64(7).

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Exploration of solid phase peptoid synthesis for the design of trifunctional hapten-lipid-TLR7/8 agonist antibody-recruiting oligomers that combine innate effector with innate activation function

Haixia Peng, Steven Martens (UGent) , Annemiek Uvyn (UGent) , Yong Chen (UGent) , Zifu Zhong (UGent) , Benoit Louage (UGent) and Bruno De Geest (UGent)

(2024) ACS APPLIED BIO MATERIALS. 8(1). p.177-188

Academic Bibliography

Zifu Zhong

Multivalent antibody-recruiters targeting fibroblast activation protein for innate immune killing

Impact of pre-existing anti-replicase immunity on the efficacy of self-amplifying mRNA vaccines

Cyclic poly(2-methyl-2-oxazoline)-lipid conjugates are good alternatives to poly(ethylene glycol)-lipids for lipid nanoparticle mRNA formulation

Admixing of mRNA with pre‐formed lipid nanoparticles containing a slightly‐cationic ionizable lipid allows for efficient mRNA transfection in vitro and in vivo

Combinatorial synthesis and evaluation of trialkyl galloyl amidoamine ionizable lipids for mRNA formulation

Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo

Enhancing anti-tumor immunity through intratumoral combination therapy with amphiphilic conjugates of oxaliplatin and imidazoquinoline TLR7/8 agonist

A genetically encoded endogenous antibody recruitment strategy for innate immune-mediated killing of cancer cells

A fentanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity

Exploration of solid phase peptoid synthesis for the design of trifunctional hapten-lipid-TLR7/8 agonist antibody-recruiting oligomers that combine innate effector with innate activation function

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