Zifu Zhong

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Impact of pre-existing anti-replicase immunity on the efficacy of self-amplifying mRNA vaccines

Xiaole Cui (UGent) , Laura Amelinck (UGent) , Oriane Gillon (UGent) , João Paulo Portela Catani, Ya Gao (UGent) , Qing Sun (UGent) , Elisabeth De Sutter (UGent) , Pieter Vervaeke (UGent) , Janne Snoeck (UGent) , Stefan Lienenklaus, et al.

(2025) Nature Communications. 17(1).

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Combinatorial synthesis and evaluation of trialkyl galloyl amidoamine ionizable lipids for mRNA formulation

Bianka Golba, Irene De Franceschi (UGent) , Zifu Zhong (UGent) , Martijn Schuijs (UGent) , Claudia Mariela Brenis Gómez (UGent) , Heleen Lauwers (UGent) , Benoit Louage (UGent) , Iasona Sheshi (UGent) , Nezha Badi (UGent) , Bruno De Geest (UGent) , et al.

(2025) JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 147(30). p.26934-26943

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Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo

Yong Chen (UGent) , Emily De Lombaerde, Aimee-Rose Bugler-Lamb (UGent) , Zifu Zhong (UGent) , Martijn Schuijs (UGent) , Claudia Mariela Brenis Gómez (UGent) , Jamie De Baere (UGent) , Mark Gontsarik (UGent) , Heleen Lauwers (UGent) , Kim Deswarte (UGent) , et al.

(2025) ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 64(28).

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Enhancing anti-tumor immunity through intratumoral combination therapy with amphiphilic conjugates of oxaliplatin and imidazoquinoline TLR7/8 agonist

Hanne Verschuere (UGent) , Sabah Kasmi (UGent) , Lutz Nuhn (UGent) , Sènan Mickaël D'Almeida, Qiwen Zhu, Zifu Zhong (UGent) , Sandy Adjemian Catani (UGent) , Benoit Louage (UGent) , Jana De Vrieze, Haijun Yu, et al.

(2025) RSC ADVANCES. 15(15). p.11662-11674

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A genetically encoded endogenous antibody recruitment strategy for innate immune-mediated killing of cancer cells

Justine Aelvoet (UGent) , Zifu Zhong (UGent) , Claudia Mariela Brenis Gómez (UGent) , Helena Catharine Aegerter (UGent) , Benoit Louage (UGent) , Bart Lambrecht (UGent) , Bruno De Geest (UGent) and Martijn Schuijs (UGent)

(2025) ADVANCED MATERIALS. 37(11).

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A f entanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity

Zifu Zhong (UGent) , Marie Deventer (UGent) , Yong Chen (UGent) , Stijn Vanhee (UGent) , Inés Lammens (UGent) , Kim Deswarte (UGent) , Yi Huang (UGent) , Tingting Ye, Haixiu Wang, Lutz Nuhn, et al.

(2025) ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 64(7).

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HER2 nanobody-poly(rhamnose) conjugates efficiently recruit anti-rhamnose antibodies from serum to the surface of HER2-expressing cells

Weiwei Mu (UGent) , Yong Chen (UGent) , Zifu Zhong (UGent) , Benoit Louage (UGent) , Heleen Lauwers (UGent) , Nick Devoogdt, Jurgen Haustraete (UGent) and Bruno De Geest (UGent)

(2024) CHEMISTRY OF MATERIALS. 36(20). p.10113-10124

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CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

Tingting Ye, Zifu Zhong (UGent) , Federica Cappellesso, Kim Deswarte (UGent) , Yong Chen (UGent) , Heleen Lauwers (UGent) , Emily De Lombaerde, Mark Gontsarik (UGent) , Stefan Lienenklaus, Dorien Van Lysebetten, et al.

(2024) BIOMATERIALS. 311.

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Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation

Emily De Lombaerde, Xiaole Cui (UGent) , Yong Chen (UGent) , Zifu Zhong (UGent) , Julie Deckers (UGent) , Giulia Mencarelli, Lisa Opsomer (UGent) , Haixiu Wang, Jamie De Baere (UGent) , Stefan Lienenklaus, et al.

(2024) ACS NANO. 18(41). p.28311-28324

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PH-triggered, lymph node focused immunodrug release by polymeric 2-propionic-3-methyl-maleic anhydrides with cholesteryl end groups

Alina G. Heck, Carolina Medina-Montano, Zifu Zhong (UGent) , Kim Deswarte (UGent) , Katharina Eigen, Judith Stickdorn, Johannes Kockelmann, Maximilian Scherger, Niek Sanders (UGent) , Stefan Lienenklaus, et al.

(2024) ADVANCED HEALTHCARE MATERIALS. 13(32).

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Zifu Zhong

Impact of pre-existing anti-replicase immunity on the efficacy of self-amplifying mRNA vaccines

Combinatorial synthesis and evaluation of trialkyl galloyl amidoamine ionizable lipids for mRNA formulation

Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo

Enhancing anti-tumor immunity through intratumoral combination therapy with amphiphilic conjugates of oxaliplatin and imidazoquinoline TLR7/8 agonist

A genetically encoded endogenous antibody recruitment strategy for innate immune-mediated killing of cancer cells

A f entanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity

HER2 nanobody-poly(rhamnose) conjugates efficiently recruit anti-rhamnose antibodies from serum to the surface of HER2-expressing cells

CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation

PH-triggered, lymph node focused immunodrug release by polymeric 2-propionic-3-methyl-maleic anhydrides with cholesteryl end groups

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