prof. dr. Roosmarijn Vandenbroucke
- ORCID iD
- 0000-0002-8327-620X
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- Journal Article
- A1
- open access
Safety and efficacy of faecal microbiota transplantation in patients with mild to moderate Parkinson's disease (GUT-PARFECT) : a double-blind, placebo-controlled, randomised, phase 2 trial
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- Journal Article
- open access
The Spreading and Effects of Human Recombinant α-Synuclein Preformed Fibrils in the Cerebrospinal Fluid of Mice
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- Journal Article
- A1
- open access
Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease
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An immunological puzzle : the adaptive immune system fuels Alzheimer’s disease pathology
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- Journal Article
- A1
- open access
Bacterial extracellular vesicles : an emerging avenue to tackle diseases
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- Journal Article
- A1
- open access
Limitations of PLX3397 as a microglial investigational tool : peripheral and off-target effects dictate the response to inflammation
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- Journal Article
- A1
- open access
Proteomic comparison between non-purified cerebrospinal fluid and cerebrospinal fluid-derived extracellular vesicles from patients with Alzheimer's, Parkinson's and Lewy body dementia
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- Journal Article
- A1
- open access
Gut microbiota regulates blood-cerebrospinal fluid barrier function and Aβ pathology
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- Journal Article
- A1
- open access
Alzheimer's disease and age-related changes in the Cu isotopic composition of blood plasma and brain tissues of the APP^(NL-G-F) murine model revealed by multi-collector ICP-mass spectrometry
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- Journal Article
- A1
- open access
Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes
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- Journal Article
- A1
- open access
Free complement and complement containing extracellular vesicles as potential biomarkers for neuroinflammatory and neurodegenerative disorders
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- Journal Article
- A1
- open access
Helicobacter pylori-derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3-C3aR signalling
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- Journal Article
- A1
- open access
Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer's disease
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- Journal Article
- A2
- open access
Characterising extracellular vesicles from individual low volume cerebrospinal fluid samples, isolated by SmartSEC
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Microdissection and whole mount scanning electron microscopy visualization of mouse choroid plexus
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Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation
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Neurometabolic and gliovascular changes in murine hepatic encephalopathy
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- Journal Article
- A1
- open access
Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics
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- Journal Article
- A1
- open access
A mouse model of hepatic encephalopathy : bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation.
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- Journal Article
- A1
- open access
The tremendous biomedical potential of bacterial extracellular vesicles
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- Journal Article
- A1
- open access
Recent insights into viral infections as a trigger and accelerator in Alzheimer's disease
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- Journal Article
- A1
- open access
Targeting gliovascular connexins prevents inflammatory blood-brain barrier leakage and astrogliosis
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- Journal Article
- A1
- open access
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation
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- Journal Article
- A1
- open access
High-precision isotopic analysis of Cu and Fe via multi-collector inductively coupled plasma-mass spectrometry reveals lipopolysaccharide-induced inflammatory effects in blood plasma and brain tissues
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- Journal Article
- A1
- open access
Fighting fire with fire : the immune system might be key in our fight against Alzheimer’s disease
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- Journal Article
- A1
- open access
The impact of systemic inflammation on Alzheimer's disease pathology
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- Journal Article
- A1
- open access
Anti-inflammatory mesenchymal stromal cell-derived extracellular vesicles improve pathology in Niemann-Pick type C disease
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- Journal Article
- A1
- open access
Special delEVery : extracellular vesicles as promising delivery platform to the brain
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Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles
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- Journal Article
- A1
- open access
Gastric Helicobacter suis infection partially protects against neurotoxicity in A 6-OHDA Parkinson’s disease mouse model
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- Journal Article
- A1
- open access
Low-grade peripheral inflammation affects brain pathology in the App(NL-G-F)mouse model of Alzheimer's disease
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- Journal Article
- A1
- open access
Involvement of the choroid plexus in the pathogenesis of Niemann-Pick disease type C
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- Journal Article
- A1
- open access
The neurogliovascular unit in hepatic encephalopathy
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- Journal Article
- A1
- open access
Extracellular vesicles : a double-edged sword in sepsis
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The power of imaging to understand extracellular vesicle biology in vivo
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- Journal Article
- A1
- open access
Importance of extracellular vesicle secretion at the blood-cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease
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- Journal Article
- A1
- open access
Effect of endotoxemia induced by intraperitoneal injection of lipopolysaccharide on the Mg isotopic composition of biofluids and tissues in mice
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- Journal Article
- A1
- open access
Profiling of extracellular small RNAs highlights a strong bias towards non-vesicular secretion
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Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
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- Journal Article
- A1
- open access
Helicobacter and the potential role in neurological disorders : there is more than Helicobacter pylori
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Tightening the retinal glia limitans attenuates neuroinflammation after optic nerve injury
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- Conference Paper
- C3
- open access
A murine model of hepatic encephalopathy : validation and neurobehavioral testing
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- Journal Article
- A1
- open access
Extracellular vesicles in Alzheimer's and Parkinson's disease : small entities with large consequences
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High-precision isotopic analysis of Mg and Ca in biological samples using multi-collector ICP-mass spectrometry after their sequential chromatographic isolation : application to the characterization of the body distribution of Mg and Ca isotopes in mice
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- Journal Article
- A1
- open access
Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model
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- Journal Article
- A1
- open access
A study of cecal ligation and puncture-induced sepsis in tissue-specific tumor necrosis factor receptor 1-deficient mice
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Interferons : a molecular switch between damage and repair in ageing and Alzheimer's disease
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- Journal Article
- A1
- open access
Biological membranes in EV biogenesis, stability, uptake, and cargo transfer : an ISEV position paper arising from the ISEV membranes and EVs workshop
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- Journal Article
- A1
- open access
Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock
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- Journal Article
- A1
- open access
Immunogenicity and protection efficacy of a naked self-replicating mRNA-based Zika virus vaccine
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- Journal Article
- A1
- open access
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
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Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain
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A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment
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- Journal Article
- A1
- open access
Choroid plexus tumor necrosis factor receptor 1 : a new neuroinflammatory piece of the complex Alzheimer's disease puzzle
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- Journal Article
- A1
- open access
The N‐terminal p.(Ser38Cys) TIMP3 mutation underlying Sorsby fundus dystrophy is a founder mutation disrupting an intramolecular disulfide bond
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- Journal Article
- A1
- open access
Overexpression of Gilz protects mice against lethal septic peritonitis
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Functional characterization of N-terminal TIMP3 mutation underlying Sorsby fundus dystrophy in Belgian and French pedigrees
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- Journal Article
- A1
- open access
A new venue of TNF targeting
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- Journal Article
- A1
- open access
Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice
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- Journal Article
- A1
- open access
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation
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- Journal Article
- A1
- open access
Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease
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- Journal Article
- A1
- open access
Quantifying the average number of nucleic acid therapeutics per nanocarrier by single particle tracking microscopy
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- Journal Article
- A1
- open access
The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection
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Simultaneous inhibition of tumor necrosis factor receptor 1 and matrix metalloproteinase 8 completely protects against acute inflammation and sepsis
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Effect of a gastral infection with zoonotic Helicobacter species on brain barrier integrity
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- Journal Article
- A1
- open access
Current research into brain barriers and the delivery of therapeutics for neurological diseases : a report on CNS barrier congress London, UK, 2017
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- Journal Article
- A1
- open access
TNFR1 inhibition with a nanobody protects against EAE development in mice
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Treatment of intestinal fibrosis in experimental inflammatory bowel disease by the pleiotropic actions of a local Rho kinase inhibitor
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Elucidation of the molecular cause underlying Sorsby fundus dystrophy in a large Belgian pedigree : N-terminal TIMP3 mutation 15 years later
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Elucidation of the molecular cause underlying Sorsby fundus dystrophy in a large Belgian pedigree : functional characterization of N-terminal TIMP3 mutation
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Elucidation of the molecular cause underlying Sorsby fundus dystrophy in a large Belgian pedigree : N-terminal TIMP3 mutation 15 years later
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A hidden epithelial barrier in the brain with a central role in regulating brain homeostasis implications for aging
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- Journal Article
- A1
- open access
MMP-3 deficiency alleviates endotoxin-induced acute inflammation in the posterior eye segment
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- Journal Article
- A1
- open access
Mouse models of ageing and their relevance to disease
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- Journal Article
- A1
- open access
Sizing nanomaterials in bio-fluids by cFRAP enables protein aggregation measurements and diagnosis of bio-barrier permeability
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- Journal Article
- A1
- open access
Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles
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- Journal Article
- A1
- open access
With mouse age comes wisdom : a review and suggestions of relevant mouse models for age-related conditions
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- Journal Article
- A1
- open access
Comment on 'Tumour necrosis factor-α plays a significant role in the Aldara-induced skin inflammation in mice'
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Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs
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Caloric restriction: beneficial effects on brain aging and Alzheimer's disease
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The effect of aging on brain barriers and the consequences for Alzheimer's disease development
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Nanobodies as therapeutics: big opportunities for small antibodies
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- Journal Article
- A1
- open access
The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease : more than just a barrier
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Development and validation of a small single-domain antibody that effectively inhibits matrix metalloproteinase 8
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Efficient analysis of mouse genome sequences reveal many nonsense variants
(2016) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 113(20). p.5670-5675 -
- Journal Article
- A1
- open access
Transient hepatic overexpression of insulin-like growth factor 2 induces free cholesterol and lipid droplet formation
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Into rather unexplored terrain : transcellular transport across the blood-brain barrier
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- Journal Article
- A1
- open access
Topical imiquimod yields systemic effects due to unintended oral uptake
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- Journal Article
- A1
- open access
Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier
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Therapeutic implications of the choroid plexus-cerebrospinal fluid interface in neuropsychiatric disorders
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- Journal Article
- A1
- open access
Amyloid β oligomers disrupt blood-CSF barrier integrity by activating matrix metalloproteinases
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- Journal Article
- A1
- open access
Friends or foes: matrix metalloproteinases and their multifaceted roles in neurodegenerative diseases
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Hematopoietic plakophilin-3 regulates acute tissue-specific and systemic inflammation in mice
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- Journal Article
- A1
- open access
Decreased TNF levels and improved retinal ganglion cell survival in MMP-2 Null mice suggest a role for MMP-2 as TNF sheddase
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Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders
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Passenger mutations confound interpretation of all genetically modified congenic mice
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- Journal Article
- A1
- open access
Synthesis and validation of a hydroxypyrone-based, potent, and specific matrix metalloproteinase-12 inhibitor with anti-inflammatory activity in vitro and in vivo
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- Journal Article
- A1
- open access
Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1
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Dual inhibition of TNFR1 and IFNAR1 in imiquimod-induced psoriasiform skin inflammation in mice
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Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1
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Determining differentially expressed miRNAs and validating miRNA-target relationships using the SPRET/Ei mouse strain
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An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17
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TNFR1-induced lethal inflammation is mediated by goblet and Paneth cell dysfunction
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Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death
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Is there new hope for therapeutic matrix metalloproteinase inhibition?
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Magnetic layer-by-layer coated particles for efficient MRI of dendritic cells and mesenchymal stem cells
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A new angle on blood–CNS interfaces: a role for connexins?
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- Journal Article
- A1
- open access
Choose your models wisely: how different murine bone marrow-derived dendritic cell protocols influence the success of nanoparticulate vaccines in vitro
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Antisense oligonucleotides against TNFR1 prevent toxicity of TNF/IFNγ treatment in mouse tumor models
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- Miscellaneous
- open access
An acute phase protein ready to go therapeutic for sepsis
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Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation
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- Journal Article
- A1
- open access
Mice overexpressing β-1,4-galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis
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- Journal Article
- A1
- open access
Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF
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- Journal Article
- A1
- open access
Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium
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Intracellular drug delivery in Leishmania-infected macrophages: evaluation of saponin-loaded PLGA nanoparticles
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Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases
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Modulation of dendritic cells by lipid grafted polyelectrolyte microcapsules
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Polyelectrolyte LbL microcapsules versus PLGA microparticles for immunization with a protein antigen
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mRNA-Lipoplex loaded microbubble contrast agents for ultrasound-assisted transfection of dendritic cells
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Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1
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A therapeutic role for matrix metalloproteinase inhibitors in lung diseases?
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Matrix metalloproteinases as drug targets in ischemia/reperfusion injury
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The first MMP in sepsis
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Matrix metalloproteinase8 has a central role in inflammatory disorders and cancer progression
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- Journal Article
- A1
- open access
The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls
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Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death
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Biodegradable Dextran Nanogels for RNA Interference: Focusing on Endosomal Escape and Intracellular siRNA Delivery
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- Journal Article
- A1
- open access
Monitoring ALS1 and ALS3 Gene Expression During In Vitro Candida albicans Biofilm Formation Under Continuous Flow Conditions
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Ultrasound exposure of lipoplex loaded microbubbles facilitates direct cytoplasmic entry of the lipoplexes
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New strategies for nucleic acid delivery to conquer cellular and nuclear membranes
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Maintaining the silence: reflections on long-term RNAi
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Evaluation of Digitally Encoded Layer-by-layer Coated Microparticles as Cell Carriers
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Can ultrasound solve the transport barrier of the neural retina?
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Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters)
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Prolonged gene silencing in hepatoma cells and primary hepatocytes after siRNA delivery with biodegradable poly(beta-amino esters)
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Loading of PEGylated siRNA lipoplexes on microbubbles restores their siRNA delivery capacity in the presence of ultrasound
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Opportunities for digitally encoded microcarriers in pharmacy and cell-based assays
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- Journal Article
- A1
- open access
Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles
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Dextran microgels for time-controlled delivery of siRNA
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- PhD Thesis
- open access
Non-viral delivery strategies to guide therapeutic nucleic acids through cellular barriers
(2008) -
Nuclear accumulation of plasmid DNA can be enhanced by non-selective gating of the nuclear pore
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Nuclear accumulation of plasmid DNA can be enhanced by non-selective gating of the nuclear pore
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Line FRAP with the confocal laser scanning microscope for diffusion measurements in small regions of 3-D samples
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Cellular entry pathway and gene transfer capacity of TAT-modified lipoplexes
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The internalization route resulting in successful gene expression depends on polyethylenimine both cell line and polyplex type
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E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion
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- Journal Article
- A1
- open access
Ultrasound-responsive polymer-coated microbubbles that bind and protect DNA
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Intracellularly degradable polyelectrolyte microcapsules
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Enhancement of nuclear uptake of therapeutic genes and macromolecules by using NLS and PTD containing viral peptides