prof. ir. Bruno De Geest

Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo

Yong Chen (UGent) , Emily De Lombaerde (UGent) , Aimee-Rose Bugler-Lamb (UGent) , Zifu Zhong (UGent) , Martijn Schuijs (UGent) , Claudia Mariela Brenis Gómez (UGent) , Jamie De Baere (UGent) , Mark Gontsarik (UGent) , Heleen Lauwers (UGent) , Kim Deswarte (UGent) , et al.

(2025) ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.

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Enhancing anti-tumor immunity through intratumoral combination therapy with amphiphilic conjugates of oxaliplatin and imidazoquinoline TLR7/8 agonist

Hanne Verschuere (UGent) , Sabah Kasmi (UGent) , Lutz Nuhn (UGent) , Sènan Mickaël D'Almeida, Qiwen Zhu, Zifu Zhong (UGent) , Sandy Adjemian Catani (UGent) , Benoit Louage (UGent) , Jana De Vrieze, Haijun Yu, et al.

(2025) RSC ADVANCES. 15(15). p.11662-11674

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Miscellaneous

Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

Sofie Rennen (UGent) , Victor Bosteels (UGent) , Clint De Nolf (UGent) , Greta Webb (UGent) , Karo Van Lil (UGent) , Sandra Maréchal (UGent) , Jessica Vetters (UGent) , Evelien Van De Velde (UGent) , Farzaneh Fayazpour (UGent) , Ria Roelandt (UGent) , et al.

(2025)

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A genetically encoded endogenous antibody recruitment strategy for innate immune-mediated killing of cancer cells

Justine Aelvoet (UGent) , Zifu Zhong (UGent) , Claudia Mariela Brenis Gómez (UGent) , Helena Catharine Aegerter (UGent) , Benoit Louage (UGent) , Bart Lambrecht (UGent) , Bruno De Geest (UGent) and Martijn Schuijs (UGent)

(2025) ADVANCED MATERIALS. 37(11).

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A f entanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity

Zifu Zhong (UGent) , Marie Deventer (UGent) , Yong Chen (UGent) , Stijn Vanhee (UGent) , Inés Lammens (UGent) , Kim Deswarte (UGent) , Yi Huang (UGent) , Tingting Ye (UGent) , Haixiu Wang (UGent) , Lutz Nuhn, et al.

(2025) ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 64(7).

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HER2 nanobody-poly(rhamnose) conjugates efficiently recruit anti-rhamnose antibodies from serum to the surface of HER2-expressing cells

Weiwei Mu (UGent) , Yong Chen (UGent) , Zifu Zhong (UGent) , Benoit Louage (UGent) , Heleen Lauwers (UGent) , Nick Devoogdt, Jurgen Haustraete (UGent) and Bruno De Geest (UGent)

(2024) CHEMISTRY OF MATERIALS. 36(20). p.10113-10124

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CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

Tingting Ye (UGent) , Zifu Zhong (UGent) , Federica Cappellesso, Kim Deswarte (UGent) , Yong Chen (UGent) , Heleen Lauwers (UGent) , Emily De Lombaerde (UGent) , Mark Gontsarik (UGent) , Stefan Lienenklaus, Dorien Van Lysebetten, et al.

(2024) BIOMATERIALS. 311.

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Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation

Emily De Lombaerde (UGent) , Xiaole Cui (UGent) , Yong Chen (UGent) , Zifu Zhong (UGent) , Julie Deckers (UGent) , Giulia Mencarelli, Lisa Opsomer (UGent) , Haixiu Wang (UGent) , Jamie De Baere (UGent) , Stefan Lienenklaus, et al.

(2024) ACS NANO. 18(41). p.28311-28324

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open access

Lysosomal trafficking and degradation of extracellular proteins via multivalent small molecule ligand display on dextran scaffolds

Benoit Louage (UGent) , Demi Defreyne (UGent) , Heleen Lauwers (UGent) , Jamie De Baere (UGent) , Annemiek Uvyn (UGent) , Haixia Peng (UGent) , Yong Chen (UGent) and Bruno De Geest (UGent)

(2024) BIOMACROMOLECULES. 26(1). p.738-750

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Relevance of controlled cooling and freezing phases in T-cell cryopreservation

Gust Nuytten (UGent) , Bruno De Geest (UGent) and Thomas De Beer (UGent)

(2024) CRYOBIOLOGY. 116.

Academic Bibliography

prof. ir. Bruno De Geest

Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo

Enhancing anti-tumor immunity through intratumoral combination therapy with amphiphilic conjugates of oxaliplatin and imidazoquinoline TLR7/8 agonist

Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

A genetically encoded endogenous antibody recruitment strategy for innate immune-mediated killing of cancer cells

A f entanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity

HER2 nanobody-poly(rhamnose) conjugates efficiently recruit anti-rhamnose antibodies from serum to the surface of HER2-expressing cells

CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation

Lysosomal trafficking and degradation of extracellular proteins via multivalent small molecule ligand display on dextran scaffolds

Relevance of controlled cooling and freezing phases in T-cell cryopreservation

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