- ORCID iD
- 0000-0001-6296-0443
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Analysis of the effect of formulation properties and process parameters on granule formation in twin-screw wet granulation
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- Journal Article
- A1
- open access
Linking material properties to 1D-PBM parameters towards a generic model for twin-screw wet granulation
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- Journal Article
- A1
- open access
Partial least squares regression to calculate population balance model parameters from material properties in continuous twin-screw wet granulation
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An extended 3-compartmental model for describing step-change experiments in pharmaceutical twin-screw feeders at different refill regimes
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- Journal Article
- A1
- open access
Model development and calibration of two-dimensional population balance model for twin-screw wet granulation based on particle size distribution and porosity
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- Journal Article
- A1
- open access
Development of diclofenac sodium 3D printed cylindrical and tubular-shaped tablets through hot melt extrusion and fused deposition modelling techniques
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Exploring the effect of raw material properties on continuous twin-screw wet granulation manufacturability
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Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures
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Identification of continuous twin-screw melt granulation mechanisms for different screw configurations, process settings and formulation
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- Journal Article
- A1
- open access
Evaluation of the influence of material properties and process parameters on granule porosity in twin-screw wet granulation
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T-shaped partial least squares for high-dosed new active pharmaceutical ingredients in continuous twin-screw wet granulation : granule size prediction with limited material information
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Validation of model-based design of experiments for continuous wet granulation and drying
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A colourful way to unravel the important fluidization-related granule size effect on semi-continuous drying
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Mechanistic modeling of semicontinuous fluidized bed drying of pharmaceutical granules by incorporating single particle and bulk drying kinetics
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An in silico framework for the robust tuning of an MPC for a continuous blender in a production line for pharmaceutical oral solid dosages.
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- Journal Article
- A1
- open access
Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids
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- Conference Paper
- C3
- open access
Two-dimensional granule property measurement using hyperspectral imaging in continuous pharmaceutical wet granulation
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Impact of alternative lubricants on process and tablet quality for direct compression
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- Journal Article
- A1
- open access
Continuous direct compression: development of an empirical predictive model and challenges regarding PAT implementation
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- Journal Article
- A1
- open access
The effect of binder types on the breakage and drying behavior of granules in a semi-continuous fluid bed dryer after twin screw wet granulation
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An extended 3-compartment model for describing step change experiments in pharmaceutical twin-screw feeders at different refill regimes
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- Journal Article
- A1
- open access
In-depth analysis of the long-term processability of materials during continuous feeding
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- Conference Paper
- C3
- open access
Model-based determination of spatial heterogeneities in a pharmaceutical fluidization process and integration into a mechanistic multi-level drying model
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- Conference Paper
- C3
- open access
An extended 3-compartmental model for describing step-change experiments in pharmaceutical twin-screw feeders at different refill regimes
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- Conference Paper
- C3
- open access
Model-based design of experiments in drug product development in continuous manufacturing
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- Journal Article
- A1
- open access
Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a rotary tablet press
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Two-dimensional population balance model for twin-screw wet granulation : model development and calibration based on particle size distribution and porosity
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In-depth analysis of the impacts of material properties on size distributions in continuous twin-screw wet granulation to construct a generic 1D population balance model
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Finite element modeling of powder compaction : mini-tablets in comparison with conventionally sized tablets
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Towards a generic population balance model for twin-screw wet granulation : from material properties to particle size distribution
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- Journal Article
- A1
- open access
Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process
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- Conference Paper
- C3
- open access
Analysis of fluidization and particle temperature in semicontinuous fluid bed drying of pharmaceutical granules
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- Journal Article
- A1
- open access
Determination of a quantitative relationship between material properties, process settings and screw feeding behavior via multivariate data-analysis
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- Journal Article
- A1
- open access
Influence of print settings on the critical quality attributes of extrusion-based 3D-printed caplets : a quality-by-design approach
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Evaluation of torque as an in-process control for granule size during twin-screw wet granulation
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- Journal Article
- A1
- open access
Spin freezing and its impact on pore size, tortuosity and solid state
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- Journal Article
- A1
- open access
Development and application of a mechanistic cooling and freezing model of the spin freezing step within the framework of continuous freeze-drying
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Melt granulation
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- Journal Article
- A1
- open access
A NIR-based study of desorption kinetics during continuous spin freeze-drying
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- Journal Article
- A1
- open access
TPLS as predictive platform for twin-screw wet granulation process and formulation development
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- Journal Article
- A1
- open access
Improvement of a 1D population balance model for twin-screw wet granulation by using identifiability analysis
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- Journal Article
- A1
- open access
Analysis of the effects of process parameters on start-up operation in continuous wet granulation
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- Journal Article
- A1
- open access
Effect of binder type and lubrication method on the binder efficacy for direct compression
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- Journal Article
- A1
- open access
Continuous twin screw granulation : impact of microcrystalline cellulose batch-to-batch variability during granulation and drying : a QbD approach
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- Journal Article
- A1
- open access
Particle-scale modeling to understand liquid distribution in twin-screw wet granulation
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- Journal Article
- A1
- open access
Macrophage reprogramming into a pro-healing phenotype by siRNA delivered with LBL assembled nanocomplexes for wound healing applications
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- Journal Article
- A1
- open access
Increasing angiogenesis factors in hypoxic diabetic wound conditions by siRNA delivery : additive effect of LbL-gold nanocarriers and desloratadine-induced lysosomal escape
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Two-dimensional moisture content and size measurement of pharmaceutical granules after fluid bed drying using near-infrared chemical imaging
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- Journal Article
- A1
- open access
The influence of equipment design and process parameters on granule breakage in a semi-continuous fluid bed dryer after continuous twin-screw wet granulation
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- Conference Paper
- C3
- open access
Clarifying the formulation effect on the drying behavior of pharmaceutical granules after wet granulation
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- Conference Paper
- C3
- open access
Model-based analysis of breakage in fluid bed drying of continuously produced pharmaceutical wet granules
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Continuous granulation
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Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation process via wet and dry binder addition
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Application of polyvinyl acetate in an innovative formulation strategy for lyophilized orally disintegrating tablets
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The impact of formulation composition and process settings of traditional batch versus continuous freeze-drying on protein aggregation
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- Journal Article
- A1
- open access
In-situ X-ray imaging of sublimating spin-frozen solutions
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Lyophilization and nebulization of pulmonary surfactant-coated nanogels for siRNA inhalation therapy
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Viscosity of API/fatty acid suspensions : pitfalls during analysis
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Continuous twin screw granulation : robustness of lactose/MCC-based formulations
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- Journal Article
- A1
- open access
4D micro-computed X-ray tomography as a tool to determine critical process and product information of spin freeze-dried unit doses
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In-line temperature measurement to improve the understanding of the wetting phase in twin-screw wet granulation and its use in process development
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- Journal Article
- A1
- open access
Model-based optimization of the primary drying phase of oral lyophilizates
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- Journal Article
- A1
- open access
Evaluation of an external lubrication system implemented in a compaction simulator
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- Journal Article
- A1
- open access
Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable formulation
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A primary drying model-based comparison of conventional batch freeze-drying to continuous spin-freeze-drying for unit doses
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Screening of pharmaceutical polymers for Extrusion-Based Additive Manufacturing of patient-tailored tablets
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Prilling of API/fatty acid suspensions : screening of additives for drug release modification
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Continuous twin screw granulation : a complex interplay between formulation properties, process settings and screw design
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Continuous twin screw granulation : impact of binder addition method and surfactants on granulation of a high-dosed, poorly soluble API
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New advances in the characterization of lyophilised orally disintegrating tablets
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- Journal Article
- A1
- open access
Predicting pharmaceutical particle size distributions using kernel mean embedding
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- Journal Article
- A1
- open access
Surface functionalization with polyethylene glycol and polyethyleneimine improves the performance of graphene-based materials for safe and efficient intracellular delivery by laser-induced photoporation
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- Journal Article
- A1
- open access
Model-based optimisation and control strategy for the primary drying phase of a lyophilisation process
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Continuous twin screw granulation : influence of process and formulation variables on granule quality attributes of model formulations
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- Conference Paper
- C3
- open access
Flowsheet modeling of the compression step of a continuous wet granulation production line
(2019) -
- Conference Paper
- C3
- open access
A model predictive control strategy of the dynamic primary drying settings for a batch freeze-drying process
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Assessment of volumetric scale-up law for processing of a sustained release formulation on co-rotating hot-melt extruders
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In-depth evaluation of data collected during a continuous pharmaceutical manufacturing process : a multivariate statistical process monitoring approach
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PAT-based batch statistical process control of a manufacturing process for a pharmaceutical ointment
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Impact of material properties and process variables on the residence time distribution in twin screw feeding equipment
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Improved label-free identification of individual exosome-like vesicles with Au@Ag nanoparticles as SERS substrate
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Prilling of API/fatty acid suspensions : processability and characterisation
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Managing API raw material variability during continuous twin-screw wet granulation
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Two-compartment modeling and dynamics of top-sprayed fluidized bed granulator
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- Journal Article
- A1
- open access
A multivariate approach to predict the volumetric and gravimetric feeding behavior of a low feed rate feeder based on raw material properties
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Process control levels for continuous pharmaceutical tablet manufacturing
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Managing active pharmaceutical ingredient raw material variability during twin-screw blend feeding
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Analysis of a pharmaceutical batch freeze dryer : resource consumption, hotspots, and factors for potential improvement
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Managing API raw material variability in a continuous manufacturing line : prediction of process robustness
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Evaluation of an in-line NIR spectroscopic method for the determination of the residence time in a tablet press
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Dual chamber cartridges in a continuous pharmaceutical freeze-drying concept : determination of the optimal dynamic infrared heater temperature during primary drying
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Continuous manufacturing of a pharmaceutical cream : investigating continuous powder dispersing and residence time distribution (RTD)
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Towards a generic model for twin-screw wet granulation
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Modeling of semicontinuous fluid bed drying of pharmaceutical granules with respect to granule size
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- Journal Article
- A1
- open access
Dynamic flowsheet model development and sensitivity analysis of a continuous pharmaceutical tablet manufacturing process using the wet granulation route
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- Journal Article
- A1
- open access
The generation and use of recombinant extracellular vesicles as biological reference material
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On the modelling of granule size distributions in twin-screw wet granulation : calibration of a novel compartmental population balance model
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Native starch as in situ binder for continuous twin screw wet granulation
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Heat transfer evaluation during twin-screw wet granulation in view of detailed process understanding
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Kernel mean embedding of distributions : a new data-driven model approach for modelling a continuous pharmaceutical twin-screw granulation process