prof. dr. ir. Matthias D'hooghe
work address
Coupure Links 653, geb. B
9000 Gent
9000 Gent
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- 2017
- Cobalt carbonyl-catalyzed carbonylation of functionalized aziridines to versatile β-lactam building blocks
- Use of α,ω-dichloroketimine building blocks for the construction of 1-azabicyclo[3.1.0]hexanes, piperidines, pyridines, pyrroles and tetrahydroindoles
- Synthesis of potent and selective HDAC6 inhibitors bearing a cyclohexane- or cycloheptane-annulated 1,5-benzothiazepine scaffold
- 2016
- Synthesis and applications of 3-methylene-4-(trifluoromethyl)azetidin-2-ones as building blocks for the preparation of mono- and spirocyclic 4-CF3-β-lactams
- Bicyclic aziridinium ions in azaheterocyclic chemistry : preparation and synthetic application of 1-azoniabicyclo[n.1.0]alkanes
- Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors
- Converting bulk sugars into prebiotics : semirational design of a transglucosylase with controlled selectivity
- A nitrilase-mediated entry to 4-carboxymethyl-β-lactams from chemically prepared 4-(cyanomethyl)azetidin-2-ones
- LiAlH4-Induced selective ring rearrangement of 2-(2-cyanoethyl)aziridines toward 2-(aminomethyl)pyrrolidines and 3-aminopiperidines as eligible heterocyclic building blocks
- Deployment of small-ring azaheterocycles as building blocks for the synthesis of organofluorine compounds