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Evaluation of viral peptide targeting to porcine sialoadhesin using a porcine reproductive and respiratory syndrome virus vaccination-challenge model
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- Journal Article
- A1
- open access
Development of a recombinant antibody to target peptides and proteins to sialoadhesin-expressing macrophages
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Porcine sialoadhesin: a newly identified xenogeneic innate immune receptor
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Single amino acid mutations in the capsid switch the neutralization phenotype of porcine circovirus 2
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- Journal Article
- A1
- open access
Interaction of the European genotype porcine reproductive and respiratory syndrome virus (PRRSV) with sialoadhesin (CD169/Siglec-1) inhibits alveolar macrophage phagocytosis
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PRRSV binding to and/or internalization by its receptor sialoadhesin on macrophages is sufficient to compromise phagocytosis
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Mapping of neutralizing epitopes in the capsid protein of porcine circovirus 2
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Antibody binding to porcine sialoadhesin reduces phagocytic capacity without affecting other macrophage effector functions
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- Journal Article
- A1
- open access
Characterization of a circulating PRRSV strain by means of random PCR cloning and full genome sequencing
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- Journal Article
- A1
- open access
Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophages
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Identification of the CD163 protein domains involved in infection of the porcine reproductive and respiratory syndrome virus
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Identification of the CD163 protein domains involved in infection of the porcine reproductive and respiratory syndrome virus
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Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy
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Porcine reproductive and respiratory syndrome virus entry into the porcine macrophage
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Susceptible cell lines for the production of porcine reproductive and respiratory syndrome virus by stable transfection of sialoadhesin and CD163
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GP4 of porcine reproductive and respiratory syndrome virus contains a neutralizing epitope that is susceptible to immunoselection in vitro
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- Journal Article
- A1
- open access
The M/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner
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Detection of truncated circular DNA species in Escherichia coli with a PCV2-containing plasmid with a single PCV2 origin of replication
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- Journal Article
- A1
- open access
Assessing the functionality of viral entry-associated domains of porcine reproductive and respiratory syndrome virus during inactivation procedures, a potential tool to optimize inactivated vaccines
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The porcine reproductive and respiratory syndrome virus requires trafficking through CD163-positive early endosomes, but not late endosomes, for productive infection
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- Journal Article
- A1
- open access
Functional impairment of PRRSV-specific peripheral CD3(+)CD8(high) cells
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- Journal Article
- A1
- open access
Development of an experimental inactivated PRRSV vaccine that induces virus-neutralizing antibodies
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Recombination of two porcine circovirus type 2 strains
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Porcine circovirus 2 infection of epithelial cells is clathrin-, caveolae- and dynamin-independent, actin and Rho-GTPase-mediated, and enhanced by cholesterol depletion
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Sialoadhesin and CD163 join forces during entry of the porcine reproductive and respiratory syndrome virus
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Involvement of proteases in porcine reproductive and respiratory syndrome virus uncoating upon internalization in primary macrophages
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- Journal Article
- A1
- open access
Genome-wide transcriptional response of primary alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus
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Gene expression profiling of porcine alveolar macrophages after antibody-mediated cross-linking of sialoadhesin (Sn, Siglec-1)
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Porcine reproductive and respiratory syndrome virus modulates apoptosis during replication in alveolar macrophages
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- Journal Article
- A1
- open access
Increased yield of porcine circovirus-2 by a combined treatment of PK-15 cells with interferon-gamma and inhibitors of endosomal-lysosomal system acidification
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- Journal Article
- A1
- open access
Inhibition of endosome-lysosome system acidification enhances porcine circovirus 2 infection of porcine epithelial cells
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Sialoadhesin (Siglec-1), a unique macrophage entry portal for targeted delivery of antigens and drugs
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IFN-α treatment enhances porcine Arterivirus infection of monocytes via upregulation of the porcine Arterivirus receptor sialoadhesin
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Porcine arterivirus attachment to the macrophage-specific receptor sialoadhesin is dependent on the sialic acid-binding activity of the N-terminal immunoglobulin domain of sialoadhesin
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Interferon alpha dependent enhancement of porcine reproductive and respiratory syndrome virus infection of monocytes
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Receptor mediated porcine arterivirus entry in macrophages
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Receptor-determined resistance of preimplantation embryos to porcine reproductive and respiratory syndrome virus
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Porcine macrophage binding of human erythrocytes is mediated by sialoadhesin
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Porcine reproductive and respiratory syndrome virus (PRRSV) entry in macrophages. Proceedings of the 19th International Pig Veterinary Society Congress, Copenhagen, Denmark, 17
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Protection of PRRSV-infected macrophages against antibody-dependent, complement-mediated cell lysis due to absence of surface expression of viral proteins. Proceedings of the 19th International Pig Veterinary Society Congress, Copenhagen, Denmark
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Efficacy of an inactivated PRRSV vaccine - Induction of virus-neutralizing antibodies and partial virological protection upon challenge
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Porcine reproductive and respiratory syndrome virus-infected alveolar macrophages contain no detectable levels of viral proteins in their plasma membrane and are protected against antibody-dependent, complement-mediated cell lysis
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Porcine circovirus 2 uses heparan sulfate and chondroitin sulfate B glycosaminoglycans as receptors for its attachment to host cells
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Sialoadhesin: a macrophage receptor involved in binding sialic acid-bearing xenogeneic cells and viruses
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Analysis of porcine reproductive and respiratory syndrome virus attachment and internalization: distinctive roles for heparan sulphate and sialoadhesin
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Back fat measurements in sows from three commercial pig herds: relationship with reproductive efficiency and correlation with visual body condition scores
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Entry process of porcine reproductive and respiratory syndrome virus in porcine alveolar macrophages
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Involvement of sialoadhesin in entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages
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Involvement of the matrix protein in attachment of porcine reproductive and respiratory syndrome virus to a heparinlike receptor on porcine alveolar macrophages.
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Effects of heparin on the entry of porcine reproductive and respiratory syndrome virus into alveolar macrophages