prof. dr. apr. Niek Sanders
- ORCID iD
- 0000-0003-4585-0343
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- Journal Article
- open access
Efficient in vitro and in vivo transfection of self-amplifying mRNA with linear poly(propylenimine) and poly(ethylenimine-propylenimine) random copolymers as non-viral carriers
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- Journal Article
- open access
Chitin-mediated blockade of chitinase-like proteins reduces tumor immunosuppression, inhibits lymphatic metastasis and enhances anti-PD-1 efficacy in complementary TNBC models
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- Journal Article
- A1
- open access
Visible light conjugation with triazolinediones as a route to degradable poly(ethylene glycol)-lipids for mRNA lipid nanoparticle formulation
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Previous and current efforts to develop a mucosal vaccine against periodontal disease : are we close yet?
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- Journal Article
- A1
- open access
Xenogeneic equine stem cells activate anti-tumor adaptive immunity in a 4T1-based intraductal mouse model for triple-negative breast cancer : proof-of-principle
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Lipid nanoparticle encapsulation empowers poly(I:C) to activate cytoplasmic RLRs and thereby increases its adjuvanticity
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Evaluation of potential administration routes of self-amplifying mRNA in chickens using a reporter vaccine
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- Journal Article
- A1
- open access
Evaluation of a self-amplifying mRNA reporter vaccine in explant models of broiler chickens
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- Journal Article
- A1
- open access
The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function
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- Journal Article
- A1
- open access
Lipid nanoparticle delivery alters the adjuvanticity of the TLR9 agonist CpG by innate immune activation in lymphoid tissue
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- Conference Paper
- C3
- open access
Novel polymers as promising non-viral carriers for self-amplifying mRNA-based applications
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One cisplatin dose suffices to maintain anti-tumor immunity and enhances anti-PD-1 efficacy in an intraductal model for triple-negative breast cancer
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- Journal Article
- A1
- open access
Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics
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- Journal Article
- A1
- open access
Regulatory guidelines and preclinical tools to study the biodistribution of RNA therapeutics
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Mucosal vaccination against periodontal disease : unexploited potential for veterinary and human oral medicine
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- Journal Article
- A1
- open access
One cisplatin dose provides durable stimulation of anti-tumor immunity and alleviates anti-PD-1 resistance in an intraductal model for triple-negative breast cancer
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- Journal Article
- A1
- open access
A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs
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Molecular therapies and vaccines face the challenges of emerging infectious diseases
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- Journal Article
- A1
- open access
A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunity
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Chitin immunomodulation stimulates anti-PD-1 therapy in an intraductal model for triple-negative breast cancer
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- Journal Article
- A1
- open access
Mucosal vaccination against periodontal disease : current status and opportunities
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- Miscellaneous
- open access
Low-dose single-shot COVID-19 mRNA vaccines lie ahead
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In Vivo Validation of a Reversible Small Molecule-Based Switch for Synthetic Self-Amplifying mRNA Regulation
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- Journal Article
- A1
- open access
OMO-1 reduces progression and enhances cisplatin efficacy in a 4T1-based non-c-MET addicted intraductal mouse model for triple-negative breast cancer
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Corticosteroids and cellulose purification improve, respectively, the in vivo translation and vaccination efficacy of sa-mRNAs
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Lipid-polyglutamate nanoparticle vaccine platform
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Sterilizing immunity against SARS‐CoV‐2 infection in mice by a single‐shot and lipid amphiphile imidazoquinoline TLR7/8 agonist‐adjuvanted recombinant spike protein vaccine**
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Corticosteroids and mRNA vaccines : a word of caution
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- Journal Article
- A1
- open access
Squaric ester-based, pH-degradable nanogels : modular nanocarriers for safe, systemic administration of toll-like receptor 7/8 agonistic immune modulators
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- Journal Article
- A1
- open access
Antibody-mediated targeting of antigens to intestinal aminopeptidase N elicits gut IgA responses in pigs
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- Journal Article
- A1
- open access
Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics : getting the message across
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Unexpected effects of a selective and potent c-MET inhibitor in an immunocompetent intraductal model for triple-negative breast cancer
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- Miscellaneous
- open access
Sterilizing immunity against SARS-CoV-2 infection in mice by a single-shot and modified imidazoquinoline TLR7/8 agonist-adjuvanted recombinant spike protein vaccine
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Potent and prolonged innate immune activation by enzyme-responsive imidazoquinoline TLR7/8 agonist prodrug vesicles
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- Journal Article
- A1
- open access
The opposing effect of type I IFN on the T cell response by non-modified mRNA-lipoplex vaccines Is determined by the route of administration
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- Journal Article
- A1
- open access
Imidazoquinoline-conjugated degradable coacervate conjugate for local cancer immunotherapy
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- Journal Article
- A1
- open access
Immune cells as tumor drug delivery vehicles
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Chlamydia : what is on the outside does matter
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- Journal Article
- A1
- open access
Comparative profiling of metastatic 4T1- vs. non-metastatic Py230-based mammary tumors in an intraductal model for triple-negative breast cancer
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- Journal Article
- A1
- open access
Expression kinetics and innate immune response after electroporation and LNP-mediated delivery of a self-amplifying mRNA in the skin
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- Journal Article
- A1
- open access
Chlamydial infection from outside to inside
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- Journal Article
- A1
- open access
Mononuclear but not polymorphonuclear phagocyte depletion increases circulation times and improves mammary tumor-homing efficiency of donor bone marrow-derived monocytes
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- Journal Article
- A1
- open access
Improving the repeatability and efficacy of intradermal electroporated self-replicating mRNA
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Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists
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- Journal Article
- A1
- open access
Immunogenicity and protection efficacy of a naked self-replicating mRNA-based Zika virus vaccine
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- Journal Article
- A1
- open access
Off-target and tumor-specific accumulation of monocytes, macrophages and myeloid-derived suppressor cells after systemic injection
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Nanoparticle-conjugate TLR7/8 agonist localized immunotherapy provokes safe antitumoral responses
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Lymph-node-targeted immune activation by engineered block copolymer amphiphiles-TLR7/8 agonist conjugates
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Small-molecule-based regulation of RNA-delivered circuits in mammalian cells
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mRNA therapeutics deliver a hopeful message
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Comparison of the expression kinetics and immunostimulatory activity of replicating mRNA, nonreplicating mRNA, and pDNA after intradermal electroporation in pigs
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- Journal Article
- A1
- open access
Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer
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Tumor immune profiling and host NF-kappaB activity assessment in a novel Py230-based intraductal model for triple-negative breast cancer
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Evaluation of a xenogeneic vascular endothelial growth factor-2 vaccine in two preclinical metastatic tumor models in mice
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The crosstalk between macrophages and 4T1 mammary tumor cells promotes metastasis in a novel intraductal model for breast cancer
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In vitro exploration of a myeloid-derived suppressor cell line as vehicle for cancer gene therapy
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Immunological, anti-angiogenic and clinical effects of intratumoral interleukin 12 electrogene therapy combined with metronomic cyclophosphamide in dogs with spontaneous cancer : a pilot study
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Intratumoural interleukin 12 gene therapy stimulates the immune system and decreases angiogenesis in dogs with spontaneous cancer
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Oral delivery of Escherichia coli persistently infected with M2e-displaying bacteriophages partially protects against influenza A virus
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Immunological and angiogenic markers during metronomic temozolomide and cyclophosphamide in canine cancer patients
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- Journal Article
- A1
- open access
Immunogenicity and safety of xenogeneic vascular endothelial growth factor receptor-2 DNA vaccination in mice and dogs
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Chitinase 3-like 1 as breast cancer metastasis biomarker for differential tumor progression in the intraductal versus the fat pad preclinical model
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Comparison of the adipose and luminal mammary gland compartment as orthotopic inoculation sites in a 4T1-based immunocompetent preclinical model for triple-negative breast cancer
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- Journal Article
- A1
- open access
De hond als kankermodel in de zoektocht naar nieuwe therapeutische alternatieven
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- Journal Article
- A1
- open access
Topical imiquimod yields systemic effects due to unintended oral uptake
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Contrast-enhanced ultrasound imaging of the anti-angiogenitic effects of interleukin-12 in pet dogs with spontaneous malignant tumors
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Coadministration of a plasmid encoding HIV-1 Gag enhances the efficacy of cancer DNA vaccines
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Aerosolized non-viral nucleic acid delivery in the vaginal tract of pigs
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Type I interferons interfere with the capacity of mRNA lipoplex vaccines to elicit cytolytic T cell responses
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Can dendritic cells improve whole cancer cell vaccines based on immunogenically killed cancer cells?
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Is intraductal inoculation of tumour cells a more relevant in vivo model for immune-competent breast cancer metastasis than the classical fat pad model?
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Synthetic biology devices and circuits for RNA-based 'smart vaccines': a propositional review
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- Journal Article
- A1
- open access
N-1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice
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- Journal Article
- A1
- open access
The challenge of West Nile virus in Europe : knowledge gaps and research priorities
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Kankercelvaccins op basis van volledige cellen : mogelijkheden en hindernissen
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Non-classical ProIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent
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Optimalization and characterization of a novel intraductal mouse mammary tumor model
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Adaptation of an intraductal mouse mastitis model to study the effect of inflammation in breast cancer metastasis
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- Journal Article
- A1
- open access
T Cell epitope mapping of the E-protein of West Nile virus in BALB/c mice
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- Journal Article
- A1
- open access
Vaccine-induced protection of Rhesus macaques against plasma viremia after intradermal infection with a European lineage 1 strain of West Nile virus
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Combination of interleukin-12 gene therapy, metronomic cyclophosphamide and DNA cancer vaccination directs all arms of the immune system towards tumor eradication
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- Journal Article
- A1
- open access
Vaccination of mice using the West Nile virus E-protein in a DNA prime-protein boost strategy stimulates cell-mediated immunity and protects mice against a lethal challenge
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Various ways to improve whole cancer cell vaccines
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- Journal Article
- A1
- open access
Non-classical ProIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent
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Innate immune response and programmed cell death following carrier-mediated delivery of unmodified mRNA to respiratory cells
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Comparison of in vivo optical systems for bioluminescence and fluorescence imaging
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Enhancing nucleic acid delivery with ultrasound and microbubbles
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Coupling of drug containing liposomes to microbubbles improves ultrasound triggered drug delivery in mice
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The use of unloaded self-made microbubbles for contrast-enhanced ultrasound imaging in dogs: potential for image-guided drug delivery in vivo
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- Journal Article
- A1
- open access
A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis
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Liposome based systems for systemic siRNA delivery: stability in blood sets the requirements for optimal carrier design
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The mechanisms behind sonoporation through the eyes of an AAV-vector
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Comparison of the gene transfer efficiency of mRNA/GL67 and pDNA/GL67 complexes in respiratory cells
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- Journal Article
- A1
- open access
Recent progress in West Nile virus diagnosis and vaccination
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Recent progress in canine tumor vaccination: potential applications for human tumor vaccines
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- Conference Paper
- P1
- open access
Fluorescence single particle tracking for sizing of nanoparticles in undiluted biological fluids
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- Journal Article
- A1
- open access
Self-assembled liposome-loaded microbubbles: the missing link for safe and efficient ultrasound triggered drug-delivery
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Absence of inhibition of DNA hydrolysing capacity of dornase alfa by azithromycin in vitro at clinical representative concentrations of azithromycin, dornase alfa and DNA
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Elucidating the mechanisms behind sonoporation with adeno-associated virus-loaded microbubbles
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Lipid-mediated gene delivery to the skin
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mRNA as gene therapeutic: how to control protein expression
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Vaccination of turkeys against Chlamydophila psittaci through optimised DNA formulation and administration
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Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death
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Flexible nanosomes (SECosomes) enable efficient siRNA delivery in cultured primary skin cells and in the viable epidermis of ex vivo human skin
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- Journal Article
- A1
- open access
The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls
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- Journal Article
- A1
- open access
Sizing nanomatter in biological fluids by fluorescence single particle tracking
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Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy
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Design and evaluation of doxorubicin-containing microbubbles for ultrasound-triggered doxorubicin delivery: cytotoxicity and mechanisms involved
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Advanced fluorescence microscopy methods illuminate the transfection pathway of nucleic acid nanoparticles
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Synergistic effects between natural histone mixtures and polyethylenimine in non-viral gene delivery in vitro
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Pulmonary delivery of mRNA: in vitro and in vivo evaluation
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siRNA containing nanoparticles: stability of encapsulation and particle size
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Extracellular barriers in respiratory gene therapy
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Delivery of mRNA via non-viral carriers
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Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging
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Cationic polymers to optimize aerosol delivery of a Chlamydophila psittaci DNA vaccine
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Ultradeformable cationic liposomes for delivery of small interfering RNA (siRNA) into human primary melanocytes
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Elucidating the Encapsulation of Short Interfering RNA in PEGylated Cationic Liposomes
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Ultrasound exposure of lipoplex loaded microbubbles facilitates direct cytoplasmic entry of the lipoplexes
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Drug loaded microbubble design for ultrasound triggered delivery
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Cutaneous short-interfering RNA therapy
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Formulation and process development of (recombinant human) deoxyribonuclease I as a powder for inhalation
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Evaluation of ethosomes for delivery of siRNA into cultured primary melanocytes and skin
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Cationic polymers to optimize aerosol delivery of a Chlamydophila psittaci DNA vaccine
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Cationic polymers to optimize aerosol delivery of a Chlamydophila psittaci DNA vaccine
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New strategies for nucleic acid delivery to conquer cellular and nuclear membranes
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Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters)
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Can ultrasound solve the transport barrier of the neural retina?
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Maintaining the silence: reflections on long-term RNAi
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- Journal Article
- A1
- open access
Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles
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Loading of PEGylated siRNA lipoplexes on microbubbles restores their siRNA delivery capacity in the presence of ultrasound
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Prolonged gene silencing in hepatoma cells and primary hepatocytes after siRNA delivery with biodegradable poly(beta-amino esters)
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A fast and sensitive method for measuring the integrity of siRNA-carrier complexes in full human serum
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Circumventing the endocytotic uptake of highly PEGylated lipoplexes by using lipoplex loaded microbubbles and ultrasound can drastically increase their transfection efficiency
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Dextran microgels for time-controlled delivery of siRNA
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Wanted and unwanted properties of surface PEGylated nucleic acid nanoparticles in ocular gene transfer
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- Journal Article
- A1
- open access
Lipoplex-loaded microbubbles for gene delivery: A Trojan horse controlled by ultrasound
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Nucleic acid delivery: Where material sciences and bio-sciences meet
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Nuclear accumulation of plasmid DNA can be enhanced by non-selective gating of the nuclear pore
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Release mechanisms for polyelectrolyte capsules
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Challenges in non-viral ocular gene transfer
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Mucolytic activity of bacterial and human chitinases
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Cellular entry pathway and gene transfer capacity of TAT-modified lipoplexes
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Sensitive spectroscopic detection of large and denatured protein aggregates in solution by use of the fluorescent dye Nile red
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Post-pegylated lipoplexes are promising vehicles for gene delivery in RPE cells
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Nuclear accumulation of plasmid DNA can be enhanced by non-selective gating of the nuclear pore
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- Journal Article
- A1
- open access
Ultrasound-responsive polymer-coated microbubbles that bind and protect DNA
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- Conference Paper
- C3
- open access
Microbubbles which bind and protect DNA against nucleases
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Role of magnesium in the failure of rhDNase therapy in patients with cystic fibrosis
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The internalization route resulting in successful gene expression depends on polyethylenimine both cell line and polyplex type
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Influence of plasmid DNA topology on the transfection properties of DOTAP/DOPE lipoplexes
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Detection of Aspergillus fumigatus hyphae in respiratory secretions by membrane filtration, fluorescent labelling and laser scanning
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In situ analysis of single-stranded and duplex siRNA integrity in living cells
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Physicochemical and transfection properties of cationic hydroxyethylcellulose/DNA nanoparticles
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The choice of a suitable oligosaccharide to prevent aggregation of PEGylated nanoparticles during freeze thawing and freeze drying
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Intracellularly degradable polyelectrolyte microcapsules
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Delivery of phosphodiester oligonucleotides: Can DOTAP/DOPE liposomes do the trick?
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Vitreous: a barrier to nonviral ocular gene therapy
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Fluorescence energy transfer to study the degradation of double-labeled oligonucleotides
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Studying biophysical barriers to DNA delivery by advanced light microscopy
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Studying the intracellular dissociation of polymer-oligonucleotide complexes by dual color fluorescence fluctuation spectroscopy and confocal imaging
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Towards a better understanding of the dissociation behavior of liposome-oligonucleotide complexes in the cytosol of cells
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Inulin is a promising cryo- and lyoprotectant for PEGylated lipoplexes
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Protection of oligonucleotides against nucleases by pegylated and non-pegylated liposomes as studied by fluorescence correlation spectroscopy
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FRET-FCS as a tool to evaluate the stability of oligonucleotide drugs after intracellular delivery
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Enhancement of nuclear uptake of therapeutic genes and macromolecules by using NLS and PTD containing viral peptides
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On the biological activity of anti-ICAM-1 oligonucleotides complexed to non-viral carriers
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- Journal Article
- A1
- open access
Three-dimensional fluorescence recovery after photobleaching with the confocal scanning laser microscope
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Mobility and stability of gene complexes in biogels
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On the transport of lipoplexes through cystic fibrosis sputum.
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Pegylated GL67 lipoplexes retain their gene transfection activity after exposure to components of CF mucus.
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Structural alterations of gene complexes by cystic fibrosis sputum.
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Interactions between oligonucleotides and cationic polymers investigated by fluorescence correlation spectroscopy.
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Complex formation between cationic polymethacrylates and oligonucleotides.
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Cystic fibrosis sputum. A barrier to the transport of nanospheres.
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The physical properties of biogels and their permeability for macromolecular drugs and colloidal drug carriers.