prof. apr. Bart De Spiegeleer
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Local skin pharmacokinetics of talarozole, a new retinoic acid metabolism blocking agent
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- Conference Paper
- C3
- open access
Spilanthes acmella ethanolic flower extract: LC-MS alkylamide profiling and its effects on sexual behavior in male rats
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Dry heat stress stability evaluation of casein peptide mixture
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- Journal Article
- A1
- open access
Stability-indicating HPLC-DAD/UV-ESI/MS impurity profiling of the anti-malarial drug lumefantrine
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Desirability function combining metabolic stability and functionality of peptides
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- Conference Paper
- C3
- open access
Fused-core HPLC method development implemented in a short-term stability study of Triple IT solution
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- Conference Paper
- C3
- open access
Classification of quorum-sensing peptides
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- Conference Paper
- C3
- open access
Short-term storage stability of Triple IT solution
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- Conference Paper
- C3
- open access
Chemical-functional space exploration of plant N-alkylamides
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- Conference Paper
- C3
- open access
New insights into electrospray ionization of patulin
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- Conference Paper
- C3
- open access
Purity profiling and the associated functional effects of a new peptide
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- Conference Paper
- C3
- open access
Structural modification and biological evaluation of Dmt1-DALDA analogues
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- Journal Article
- A1
- open access
Spilanthes acmella ethanolic flower extract: LC-MS alkylamide profiling and its effects on sexual behavior in male rats
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Differential gene expression of the toll-like receptor-4 cascade and neutrophil function in early- and mid-lactating dairy cows
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Anaphylatoxin C5a-induced toll-like receptor 4 signaling in bovine neutrophils
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- Conference Paper
- C3
- open access
ADME behaviour of some Dmt-DALDA-peptide derivatives
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- Conference Paper
- C3
- open access
Blood-brain barrier and ADME properties of selected DALDA-peptide derivatives
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Blood-brain barrier characteristics of opioid peptides
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- Conference Paper
- C3
- open access
Chemical-functional space exploration of plant N-alkylamides
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- Conference Paper
- C3
- open access
Development of a quorum-sensing peptide database: quorumpeps
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- Journal Article
- A1
- open access
Variation of inflammatory dynamics and mediators in primiparous cows after intramammary challenge with Escherichia coli
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Ion mobility spectrometry as a high-throughput technique for in vitro transdermal Franz diffusion cell experiments of ibuprofen
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- Conference Paper
- C3
- open access
New N-alkylamides from Anacyclus pyrethrum
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LC-MS profiling of N-alkylamides in Spilanthes acmella extract and the transmucosal behaviour of its main bio-active spilanthol
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- Conference Paper
- C3
- open access
Functional drugability of MOR-opioid peptides through desirability
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Severity variation of clinical E.coli mastitis in cows: where do we stand?
(2010) -
- Conference Paper
- C3
- open access
Influence of injection volume and solvent strength on spilantholchromatography using RP fused-core amide stationary phase
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Analytical characterization and comparison of the blood-brain barrier permeability of eight opioid peptides
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- Conference Paper
- C3
- open access
Functional differences of iodinated obestatin peptides: in vitro metabolic stability profile
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- Conference Paper
- C3
- open access
Comparative drugability evaluation of MOR opioid peptides in functional brain research
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- Conference Paper
- C3
- open access
Dry heat stress stability of casein hydrolysate peptide mixture
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- Conference Paper
- C3
- open access
Bioactive peptides as potential new drugs: from analytics to tissue bath functionality
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An integrated view on how the management of the dry period length of lactating cows could affect mammary biology and defense
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- Conference Paper
- C3
- open access
LC-MS quality control of modified pharmaceutical proteins : the somatropin case
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- Conference Paper
- C3
- open access
Chemical quality control of peptide functionality testing in tissue baths
(2010) -
- Conference Paper
- C3
- open access
Stability indicating method development for low level calcitonin
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Metabolic fate of lactoferricin based antimicrobial peptides: effect of truncation and incorporation of amino acid analogs on the in vitro metabolic stability
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Transdermal behaviour of the N-alkylamide spilanthol (affinin) from Spilanthes acmella (Compositae) extracts
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The influence of morphine on 5-HT2A receptor availability using SPECT: a preliminary study in dogs
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Quality analysis of salmon calcitonin in a polymeric bioadhesive pharmaceutical formulation: sample preparation optimization by DOE
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Amide fused-core chromatography of spilanthol as applied on a patch development
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The metabolisation of different iodinated peptide species
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- Conference Paper
- C3
- open access
Nanoparticles : between food handling and skin penetration
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Quality analytics of internet pharmaceuticals
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- Conference Paper
- C3
- open access
HPLC-MS characterisation of chelate modified somatropin
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- Conference Paper
- C3
- open access
Characterisation of modified pharmaceutical proteins: the somatropin case
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The metabolisation of different iodinated peptide species
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- Conference Paper
- C3
- open access
Morphine decreases 5-HT2A receptor binding measured with SPECT in the canine frontal cortex
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- Conference Paper
- C3
- open access
LC-MS characterization and cell-binding properties of chelate modified somatropin
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Vancomycin release from poly(D,L-lactic acid) spray-coated hydroxyapatite fibers
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Serotonin 2A receptor imaging in canine behavioural disorders : an animal model for human psychiatric disorders
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In vitro evaluation of gentamicin- and vancomycin-containing minitablets as a replacement for fortified eye drops
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Hydrophilic interaction LC of peptides: columns comparison and clustering
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- Journal Article
- A1
- open access
A new discriminative criterion for the development of Franz diffusion tests for transdermal pharmaceuticals
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- Conference Paper
- C3
- open access
Chemical and metabolic stability of lactoferricin-based cationic antimicrobial tripeptides
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Transdermal behaviour of the N-alkylamide spilanthol
(2009) -
- Conference Paper
- C3
- open access
Concentration-dependent peptide losses during the drying step in the sample preparation: influence of additives
(2009) -
- Conference Paper
- C3
- open access
Functional quality of new peptide drugs: receptor-binding and tissue-interactions
(2009) -
The paradox of scored tablets: a cost-saving risk
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Analytical, biopharmaceutical and regulatory evaluation of topical testosterone preparations
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Central administration of obestatin fails to show inhibitory effects on food and water intake in mice
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Adsorption of peptides at the sample drying step: influence of solvent evaporation technique, vial material and solution additive
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Prepartum immune status and mammary gland involution in cows with modified dry period lengths
(2009) -
Gene expression of TLR4 and associated genes in bovine neutrophils during early and mid lactation
(2009) -
Peptidomics of bovine mammary gland: Concentration-dependent peptide losses during sample preparation can be minimized applying n-nonyl-β-D-glucopyranoside
(2009) -
- Conference Paper
- C3
- open access
Qbd analytical development of calcitonin bioadhesive formulation
(2009) -
- Conference Paper
- C3
- open access
Analytical characterization of the BBB functionality of the opioid-peptides EM-1, EM-2 and CTAP.
(2009) -
Innate defense of bovine teat canal in nonlactating Holstein cows
(2009) -
Functional genomics of bovine neutrophil during lactation
(2009) -
- Conference Paper
- C3
- open access
Analytical profiling, modeling and transdermal/transmucosal characteristics of bioactive N-alkylamides
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Development of peptide receptor binding assays: methods to avoid false negatives
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Quality specifications for peptide drugs: a regulatory-pharmaceutical approach
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Chemical and metabolic stability of lactoferricin-derived cationic antimicrobial tripeptides
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The use of [I-123]-2-iodo-L-phenylalanine as an early radiotherapy evaluation tool: In vitro R1M rabdomyosarcoma cell and in vivo mouse experiments
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- Conference Paper
- C3
- open access
Development of quality specifications for peptide drugs
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HPLC analysis and stress stability of peptide drugs
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Impurity profiling quality control testing of synthetic peptides using liquid chromatography-photodiode array-fluorescence and liquid chromatography-electrospray ionization-mass spectrometry: the obestatin case
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LC-UV/MS characterization and DOE optimization of the iodinated peptide obestatin
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- Conference Paper
- C1
- open access
Quality assessment of pharmacy and internet obtained topical testosterone formulations.
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Development of system suitability tests for in vitro skin integrity control: impedance and capacitance.
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Solvent effects on the transdermal penetration of the OECD model compound caffeine.
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The effect of dry period length reduction to 28 days on the performance of multiparous dairy cows in the subsequent lactation
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Growth factor/peptide receptor imaging for the development of targeted therapy in oncology
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- Conference Paper
- C1
- open access
Bovine mammary gland peptibolomics: Adsorption of peptides at the sample drying step
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- Conference Paper
- C1
- open access
Inhibiting protease-activity in peptidomics: strategies during sampling and receptor studies
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- Conference Paper
- C1
- open access
Screening methodology for chemical and metabolic stability of potential peptide drugs
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In vitro metabolic stability of obestatin: Kinetics and identification of cleavage products
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Nuclear medicine and large animal studies in the pharmacological development of psychotropics
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- Conference Paper
- C3
- open access
Pharmaceutical drugability of peptides
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Stability of the OECD model compound benzoic acid in receptor fluids of Franz diffusion cells
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The effect of pipamperone on the binding index of 123I-5I-R91150, a selective 5-HT2A receptor radioligand,in the canine brain
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Assessment of the solid-state composition of an active salicylanilide compound by FT-Raman spectroscopy
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Variation in gene expression of the TLR4 pathway in unstimulated circulating bovine neutrophils during early and mid lactation
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- Conference Paper
- C1
- open access
Adsorption of the model drug testosterone on laboratory tips
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- Conference Paper
- C1
- open access
Peptibolomics of the cows' udder: peptide profiling of the teat canal
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Comparison of the wetting properties of three commonly used simulated intestinal fluids used as dissolution media in the characterization of drugs
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- Journal Article
- A1
- open access
Bovine blood neutrophil acyloxyacyl hydrolase (AOAH) activity during endotoxin and coliform mastitis
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Use of [I-121]-2-iodo-L-phenylalanine as a tumor imaging agent in two dogs with synovial cell sarcoma
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Analysis of iodinated peptides by LC-DAD/ESI ion trap mass spectrometry
(2007) JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 850(1-2). p.213-220 -
The effect of pipamperone on the binding index of 123I-5I-R91150, a selective 5-HT2A receptor radioligand, in the canine brain
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Imaging of the serotonin-2A receptor before and after pipamperone administration in the canine brain
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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds
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Stoichiometry of complexes by quantifying qualitative UV-VIS spectroscopic shifts
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- Conference Paper
- C1
- open access
Analytical characterisation of arsenic anticoccidials and their determination in poultry feed
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Synthesis and HPLC-purification of [Br-77]TMC125-R165335 (etravirine), a new anti-HIV drug of the DAPY-NNRTI class
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- Conference Paper
- C1
- open access
RADIOSTABILITY OF VANCOMYCIN
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Development of a dissolution method for a meloxicam oral suspension using solubility and IVIVC data
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Comparative biodistribution study of the new tumor tracer [I-123]-2-iodo-L-phenylalanine with [I-123]-2-iodo-L-tyrosine
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Characterisation of a preservative system in an oily preparation
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Influence of sedation and data acquisition method on tracer uptake in animal models: [I-123]-2-iodo-L-phenylalanine in pentobarbital-sedated tumor-bearing athymic mice
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The importance of the cosolvent propylene glycol on the antimicrobial preservative efficacy of a pharmaceutical formulation by DOE-ruggedness testing
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Optimization by experimental design of precursor synthesis and radiolabeling of 2-iodo-L-phenylalanine, a novel amino acid for tumor imaging.
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I-123/125-labelled 2-iodo-L-phenylalanine and 2-iodo-D-phenylalanine: comparative uptake in various tumour types and biodistribution in mice
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Determination of the relative amounts of three crystal forms of a benzimidazole drug in complex finished formulations by FT-Raman spectroscopy
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Evaluation of the stability of chlortetracycline in granular premixes by monitoring its conversion into degradation products
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Mass uniformity: Influence of operational compression conditions on breakability of scored tablets as part of manufacturing robustness evaluation
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In vivo evaluation and dosimetry of I-123-2-iodo-D-phenylalanine, a new potential tumor-specific tracer for SPECT in an R1M rhabdomyrosarcoma athymic mouse model
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Anti-microbial preservatives in oily preparations
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Physical stability of diluted suspo-emulsions
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Physico-chemical screening tests using IV2SOL technology in the development of liquid pharmaceutical formulations
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Distribution study of three-phase emulsions using confocal laser scanning microscopy (CLSM)
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Raman spectroscopy in the polymorphic characterisation of drugs
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Investigation of preservative systems by experimental design: drug product optimisation and robustness characterisation
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Statistical analysis of tablet breakability methods
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Evaluation of dissolution profiles using principal component analysis
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Dissolution stability and IVIVC investigation of a buccal tablet
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A novel bending point criterion for dissolution profile interpretation
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Half-fraction and full factorial designs versus central composite design for retention modelling in reversed-phase ion-pair liquid chromatography
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Relationship between content limits and assay methods : an interlaboratory statistical evaluation
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High-performance thin-layer chromatographic analysis of thiazine dyes on silica, cyano, and reversed-phase C18 layers
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Planar chromatography : most flexible analytic technique in the pharmaceutical industry
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The tissue distribution in rats of [PT-195M]carboplatin following intravenous, intraperitoneal and oral administration
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Synthese en analyse van N-13-cisplatin, (ethyleendiamine)(1-C-11-malonaat)platinum(II) en Pt-195m-carboplatin
(1989) -
Planar chromatography of Echinacea species extracts with automated multiple development
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High performance liquid chromatography stability study of malonyl-coenzyme A, using statistical experimental designs
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Structural characterization of cisplatin analogues by fast atom bombardment (FAB) and laser microprobe mass spectrometry (LAMMA)
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A rapid high-performance thin-layer chromatographic screening method for sulfonamides residues in animal muscle tissues
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High-performance liquid chromatography of α-substituted acetic acid derivatives
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Synthesis and radiopharmaceutical preparation of (ethylenediamine) (1-carbon-11-malonate) platinum(II) for PET studies
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A strategy for two-dimensional, high-performance thin-layer chromatography, applied to local anesthetics
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Intellectual flexibility
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Criterion for evaluation and optimization in thin-layer chromatography
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Direct assay for phosphotransacetylase and acetyl-coenzyme a carboxylase by high-performance liquid chromatography
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Rapid determination of malonic acid by ion-pair reversed-phase high-performance liquid chromatography
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Microscale synthesis of nitrogen-13-labeled cisplatin
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Determination of methyl nicotinate in pharmaceutical creams by high-performance thin-layer chromatography
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Quantitative analysis of cis-dichlorodiammineplatinum(II) by high-performance thin-layer chromatography