Department of Biomedical molecular biology
3790 publications
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- Journal Article
- A1
- open access
Microbes exploit death-induced nutrient release by gut epithelial cells
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- Journal Article
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Necroptosis signalling promotes inflammation, airway remodelling and emphysema in COPD
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MLKL in cancer : more than a necroptosis regulator
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- Journal Article
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Patients with COVID-19 : in the dark-NETs of neutrophils
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- Journal Article
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Enhanced siRNA delivery and selective apoptosis induction in H1299 cancer cells by layer-by-layer-assembled Se nanocomplexes : toward more efficient cancer therapy
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The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses
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- Journal Article
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- open access
Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL
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Punching holes in cellular membranes : biology and evolution of gasdermins
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Impact of myeloid RIPK1 gene deletion on atherogenesis in ApoE-deficient mice
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Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
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- Journal Article
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- open access
Characteristic ERK1/2 signaling dynamics distinguishes necroptosis from apoptosis
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Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis
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GSDME and its role in cancer : from behind the scenes to the front of the stage
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- Journal Article
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- open access
Layer by layer assembled chitosan-coated gold nanoparticles for enhanced siRNA delivery and silencing
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A TLR3 Ligand Reestablishes Chemotherapeutic Responses in the Context of FPR1 Deficiency
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Nanoparticle-sensitized photoporation enables inflammasome activation studies in targeted single cells dagger
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- Journal Article
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ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation
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- Journal Article
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RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury
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- Journal Article
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Plasma membrane permeabilization following cell death : many ways to dye!
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- Journal Article
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Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor
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- Journal Article
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The neurogliovascular unit in hepatic encephalopathy
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- Journal Article
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Anti-inflammatory mesenchymal stromal cell-derived extracellular vesicles improve pathology in Niemann-Pick type C disease
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- Journal Article
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Profiling of extracellular small RNAs highlights a strong bias towards non-vesicular secretion
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- Journal Article
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Low-grade peripheral inflammation affects brain pathology in the App(NL-G-F)mouse model of Alzheimer's disease
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- Journal Article
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Involvement of the choroid plexus in the pathogenesis of Niemann-Pick disease type C
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- Journal Article
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Special delEVery : extracellular vesicles as promising delivery platform to the brain
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The power of imaging to understand extracellular vesicle biology in vivo
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- Journal Article
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Extracellular vesicles : a double-edged sword in sepsis
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Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles
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- Journal Article
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Importance of extracellular vesicle secretion at the blood-cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease
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Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
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- Journal Article
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Helicobacter and the potential role in neurological disorders : there is more than Helicobacter pylori
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- Journal Article
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Gastric Helicobacter suis infection partially protects against neurotoxicity in A 6-OHDA Parkinson’s disease mouse model
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- Journal Article
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From DNA copy number gains and tumor dependencies to novel therapeutic targets for high-risk neuroblastoma
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Polo-like kinase 1 (PLK1) signaling in cancer and beyond
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Bovine pluripotent stem cells : a challenging approach for the development of cultured meat
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- Journal Article
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- open access
Deep learning is widely applicable to phenotyping embryonic development and disease
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Pannexin-1 channel regulates nuclear content packaging into apoptotic bodies and their size
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The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation
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Unraveling cell death modalities during influenza infection, vaccination, and cancer therapy
(2021) -
Early prediction of response to vedolizumab in patients with active inflammatory bowel disease : a prospective real-life multicentre cohort study
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The conventional dendritic cell lineage is born
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Individuals with NR5A1 (SF1) mutations and atypical sex development and their asymptomatic family member carriers are at high risk of hyposplenism
(2021) HORMONE RESEARCH IN PAEDIATRICS. In Hormone Research in Paediatrics 94(supplement 1). p.42-43 -
- Conference Paper
- C3
- open access
GTF3A mutations in a patient with herpes simplex encephalitis reveals a novel role in viral immunity by transcribing 5S rRNA pseudogenes serving as RIG-I ligands
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- Journal Article
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Microcirculatory function during endotoxemia : a functional citrulline-arginine-NO pathway and NOS3 complex is essential to maintain the microcirculation
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Whole transcriptome profiling of liquid biopsies from tumor xenografted mouse models enables specific monitoring of tumor-derived RNA
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Whole transcriptome profiling of liquid biopsies from tumor xenografted mouse models enables specific monitoring of tumor-derived RNA
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Does tissue imprinting restrict macrophage plasticity?
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- Journal Article
- A2
- open access
A new transgenic mouse line for imaging mitochondrial calcium signals
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- Journal Article
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Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice
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- Journal Article
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OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity
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First patient with bloom syndrome caused by a deep intronic variant leading to pseudoexon activation
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Mutations in LTBP1 cause autosomal recessive cutis laxa syndrome
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ImmGen at 15
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- PhD Thesis
- open access
CRISPR/Cas9 mediated modeling of TP53 and PTEN related malignancies in Xenopus tropicalis
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The glucocorticoid receptor in acute inflammation : new molecular insights and development of a new GR dimerization mutant
(2020) -
Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer
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Comparison of the PU.1 transcriptional regulome and interactome in human and mouse inflammatory dendritic cells
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TAO-kinase 3 governs the terminal differentiation of conventional dendritic cells
(2020) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 117(49). p.31331-31342 -
- Journal Article
- A1
- open access
Three-dimensional visualization of APEX2-tagged Erg11 in Saccharomyces cerevisiae using Focused Ion Beam Scanning Electron Microscopy
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Phytohormones : diverses molécules bioactives influant sur le métabolisme et l’inflammation chez l’homme
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The EMT transcription factor ZEB2 promotes proliferation of primary and metastatic melanoma while suppressing an invasive, mesenchymal-like phenotype
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Integrin expression changes on the T cells subsets influence the response to vedolizumab in inflammatory bowel disease patients
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- Journal Article
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Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant
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Isolation of Trypanosoma brucei brucei infection-derived splenic marginal zone B cells based on CD1dHigh/B220High surface expression in a two-step MACS-FACS approach
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Off-target glycans encountered along the synthetic biology route toward humanized N-glycans in Pichia pastoris
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Selected IL-1 activity on CD8+ T cells allows for safe enhancement of cellular immune responses
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An extracellular microRNA can rescue lives in sepsis
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GATA2 deficiency and haematopoietic stem cell transplantation : challenges for the clinical practitioner
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Nanoscopic X-ray imaging and quantification of the iron cellular architecture within single fibroblasts of Friedreich's ataxia patients
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- Journal Article
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- open access
Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis
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Mutations in ATP6V1E1 or ATP6V1A cause autosomal-recessive cutis laxa (vol 100, pg 216, 2017)
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- Journal Article
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Single-chain soluble receptor fusion proteins as versatile cytokine inhibitors
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- Journal Article
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Necroptosis in immuno-oncology and cancer immunotherapy
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- Journal Article
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Macrophage subsets in obesity, aligning the liver and adipose tissue
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- Journal Article
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Glucocorticoids in sepsis : to be or not to be
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Myeloid cells TREM down anti-tumor responses
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- Journal Article
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- open access
Identification of MYC as an antinecroptotic protein that stifles RIPK1-RIPK3 complex formation
(2020) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 117(33). p.19982-19993 -
Stabilization of the TAK1 adaptor proteins TAB2 and TAB3 is critical for optimal NF-kappa B activation
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Taking the STING out of sepsis?
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MALT1 targeting suppresses CARD14‐induced psoriatic dermatitis in mice
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ST2 as checkpoint target for colorectal cancer immunotherapy
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- Journal Article
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Guidelines and definitions for research on epithelial–mesenchymal transition
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GILZ in sepsis : 'poor is the pupil who does not surpass his master'
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Glucocorticoids limit lipopolysaccharide-induced lethal inflammation by a double control system
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RIPK1 kinase-dependent death : a symphony of phosphorylation events
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- Journal Article
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Respiratory Syncytial Virus infection promotes necroptosis and HMGB1 release by airway epithelial cells
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- Journal Article
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Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
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- Journal Article
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Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation
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- Journal Article
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Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation
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Establishment and maintenance of the macrophage niche
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- Journal Article
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Transcriptional regulation of DC fate specification
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Inflammatory type 2 cDCs acquire features of cDC1s and macrophages to orchestrate immunity to respiratory virus infection
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Metabolites released from apoptotic cells act as tissue messengers
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Effect of sample preparation techniques upon single cell chemical imaging : a practical comparison between Synchrotron Radiation based X-ray Fluorescence (SR-XRF) and Nanoscopic Secondary Ion Mass Spectrometry (nano-SIMS)
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- Journal Article
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Reverse engineering synthetic antiviral amyloids
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- Journal Article
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mRNA encoding a bispecific single domain antibody construct protects against influenza A virus infection in mice
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- Journal Article
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Long-term MALT1 inhibition in adult mice without severe systemic autoimmunity
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- Book Chapter
- open access
Localization and expression of nuclear factor of activated T-cells 5 in myoblasts exposed to pro-inflammatory cytokines or hyperosmolar stress and in biopsies from myositis patients
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- Journal Article
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Recombinant viruses delivering the necroptosis mediator MLKL induce a potent antitumor immunity in mice