Department of Biomedical molecular biology
3790 publications
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Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis
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Regulation of inflammasome signaling by the linear deubiquitinase OTULIN
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- Journal Article
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A guide to the expanding field of extracellular vesicles and their release in regulated cell death programs
(2024) FEBS JOURNAL. -
An immunological puzzle : the adaptive immune system fuels Alzheimer’s disease pathology
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- Journal Article
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Alterations in the innate and adaptive immune system in a real-world cohort of multiple sclerosis patients treated with ocrelizumab
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Visualisation of microalgal lipid bodies through electron microscopy
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Haploinsufficiency of ZFHX3, encoding a key player in neuronal development, causes syndromic intellectual disability
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- Journal Article
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HTSplotter : an end-to-end data processing, analysis and visualisation tool for chemical and genetic in vitro perturbation screening
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Laser-induced vapor nanobubbles for B16-F10 melanoma cell killing and intracellular delivery of chemotherapeutics
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- Journal Article
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Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease
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- Journal Article
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Human iPSC modeling recapitulates in vivo sympathoadrenal development and reveals an aberrant developmental subpopulation in familial neuroblastoma
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Evaluation of single-sample network inference methods for precision oncology
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- Journal Article
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The Spreading and Effects of Human Recombinant α-Synuclein Preformed Fibrils in the Cerebrospinal Fluid of Mice
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Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown
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- PhD Thesis
- open access
ADAR1 is a central regulator of the dsRNA response : from A-to-Z RNA
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SAMHD1 compound heterozygous rare variants associated with moyamoya and mitral valve disease in the absence of other features of Aicardi-Goutières syndrome
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A20 : a jack of all trades
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Age-dependent signature of serum inflammatory cytokines IL-1Ra, IL-1β, IL-6, IL-18, TNF-α, CXCL9 and CXCL10 in healthy children
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- Journal Article
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Type 1 immunity enables neonatal thymic ILC1 production
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Chimeric and mutant CARD9 constructs enable analyses of conserved and diverged autoinhibition mechanisms in the CARD-CC protein family
(2024) FEBS JOURNAL. -
- Journal Article
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- open access
Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids
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- Journal Article
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Automated antibody dispensing to improve high-parameter flow cytometry throughput and analysis
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Targeting efferocytosis in inflammaging
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Reflective multi-immersion microscope objectives inspired by the Schmidt telescope
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- Journal Article
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Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF
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- Journal Article
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S100A8-enriched microglia populate the brain of tau-seeded and accelerated aging mice
(2024) AGING CELL. -
- Journal Article
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Tissue niche occupancy determines the contribution of fetal- versus bone-marrow-derived macrophages to IgG effector functions
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Evolutionary origin of Hoxc13-dependent skin appendages in amphibians
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Thymus development during acute inflammation
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Improving cardiac differentiation of human pluripotent stem cells by targeting ferroptosis
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- Journal Article
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ZBP1activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice
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- Journal Article
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Safety and efficacy of faecal microbiota transplantation in patients with mild to moderate Parkinson's disease (GUT-PARFECT) : a double-blind, placebo-controlled, randomised, phase 2 trial
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- Journal Article
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Identification and validation of extracellular vesicle reference genes for the normalization of RT‐qPCR data
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- Journal Article
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Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes
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- Journal Article
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Ferroptosis and pyroptosis signatures in critical COVID-19 patients
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- Journal Article
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LC3-independent autophagy is vital to prevent TNF cytotoxicity
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- Journal Article
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Neutrophil metalloproteinase driven spleen damage hampers infection control of trypanosomiasis
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- Journal Article
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Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism : possible implication for Alzheimer's disease
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Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space
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Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity
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- Journal Article
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HSPB8 frameshift mutant aggregates weaken chaperone-assisted selective autophagy in neuromyopathies
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- Journal Article
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Phagocytosis in the retina promotes local insulin production in the eye
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- Journal Article
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Inhibition of RIPK1 kinase does not affect diabetes development : beta-cells survive RIPK1 activation
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- Journal Article
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RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD
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- Journal Article
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Mosaic RBD nanoparticles induce intergenus cross-reactive antibodies and protect against SARS-CoV-2 challenge
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- Journal Article
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Spatial and temporal regulation of parent-of-origin allelic expression in the endosperm
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- Journal Article
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Circulating cell-free DNA in health and disease : the relationship to health behaviours, ageing phenotypes and metabolomics
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Death by TNF : a road to inflammation
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- Journal Article
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Gasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infection
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Therapeutic exploration of ferroptosis in multiple sclerosis
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- Journal Article
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- open access
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
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- Journal Article
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From PERK to RIPK1 : design, synthesis and evaluation of novel potent and selective necroptosis inhibitors
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- Journal Article
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Proteolytic activity of the paracaspase MALT1 is involved in epithelial restitution and mucosal healing
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- Journal Article
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Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes
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- Journal Article
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Mousepost 2.0, a major expansion of the resource
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Innate immune sensors balance infection surveillance and autoinflammation
(2023) -
- Journal Article
- A2
- open access
From helping to regulating : a transcriptomic profile of Ifng+ Il10+ Il21+ Cd4+ Th1 cells indicates their role in regulating inflammation during experimental trypanosomosis
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Chronic pathology of experimental Trypanosoma evansi infection is the combined result of an extra-medullary erythropoiesis abrogation, a failing host B cell response, and the induction of a unique Th1 cell population
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Exploring the role of RIPK1 in T cell homeostasis
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- Journal Article
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The pathogenesis of African trypanosomiasis
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Studying the pathogenesis of persistent fatigue in inflammatory bowel diseases
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- Journal Article
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LXR signaling controls homeostatic dendritic cell maturation
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Detoxification mechanisms in the TNF pathway
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- Journal Article
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Cell behavior changes and enzymatic biodegradation of hybrid electrospun poly(3-hydroxybutyrate)-based scaffolds with an enhanced piezoresponse after the addition of reduced graphene oxide
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- Book Chapter
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Nanobody technology and new molecular biology methods to advance rapid diagnostic test for neglected tropical diseases
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- Journal Article
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Paneth cells as the cornerstones of intestinal and organismal health : a primer
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Activation and viral escape of ZBP1-mediated host cell death
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Impact of EMT on regulated cell death and immune activation in colorectal cancer
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- Journal Article
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HNF1B alters an evolutionarily conserved nephrogenic program of target genes
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Molecular mechanisms of nemorosone-induced ferroptosis in cancer cells
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Caspase inhibition modulates monocyte-derived macrophage polarization in damaged tissues
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Hepatic glutamine synthetase controls N-5-methylglutamine in homeostasis and cancer
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The role of regulated cell death in chronic obstructive pulmonary disease (COPD)
(2023) -
- Journal Article
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Genetic variants in ARHGEF6 cause congenital anomalies of the kidneys and urinary tract in humans, mice, and frogs
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- Journal Article
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Glycyrrhizin-based hydrogels accelerate wound healing of normoglycemic and diabetic mouse skin
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- Journal Article
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IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer
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- Journal Article
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Helicobacter pylori-derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3-C3aR signalling
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Free complement and complement containing extracellular vesicles as potential biomarkers for neuroinflammatory and neurodegenerative disorders
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A redundant transcription factor network steers spatiotemporal Arabidopsis triterpene synthesis
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Sterile triggers drive joint inflammation in TNF‐ and IL-1β‐dependent mouse arthritis models
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Gut microbiota regulates blood-cerebrospinal fluid barrier function and Aβ pathology
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Endosperm cell death promoted by NAC transcription factors facilitates embryo invasion in Arabidopsis
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- Journal Article
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Functions of the RIP kinase family members in the skin
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- Miscellaneous
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Novel role for linear ubiquitination in regulating NFAT1 stability
(2023) FEBS JOURNAL. -
- Journal Article
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The epithelial-mesenchymal plasticity landscape: principles of design and mechanisms of regulation
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- Journal Article
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A concise guide to choosing suitable gene expression systems for recombinant protein production
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STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity
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- Journal Article
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Exploring species-specificity in TLR4/MD-2 inhibition with amphiphilic lipid a mimicking glycolipids
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- Journal Article
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Cell death checkpoints in the TNF pathway
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- Miscellaneous
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Spns2/S1P: it takes two to tango with inflammation and metabolic rewiring during sepsis
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- Journal Article
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Phase separation-based visualization of protein-protein interactions and kinase activities in plants
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Exploring Paneth cells : uncovering their homeostatic diversity and role in TNF-induced SIRS
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- Journal Article
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A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state
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Studying microglia and astrocytes in the liver-brain axis during chronic experimental hepatic encephalopathy
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- Journal Article
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Normal lymphocyte homeostasis and function in MALT1 protease-resistant HOIL-1 knock-in mice
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A role for partial epithelial-to-mesenchymal transition in enabling stemness in homeostasis and cancer
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Systematic compositional analysis of exosomal extracellular vesicles produced by cells undergoing apoptosis, necroptosis and ferroptosis
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Syntaxin 18 defects in human and zebrafish unravel key roles in early cartilage and bone development
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Photothermal nanofibers enable macromolecule delivery in unstimulated human T cells
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Apoptotic cell death in disease : current understanding of the NCCD 2023