Academic Bibliography
https://biblio.ugent.be/
Ghent University Academic Bibliography2000-01-01T00:00+00:001monthlyThe cost of lifelong LUTS : a systematic literature review
https://biblio.ugent.be/publication/01HN2KV5MRY13Q84GPHNVKYEXQ
Holm-Larsen, ToveVan den Ende, MauroWendelboe, Helena GoldsteinVerbakel, IrinaBoukheir, GeorgeHervé, FrançoisEveraert, Karel2024Background: Lower urinary tract symptoms (LUTS) are highly prevalent and very bothersome. To support the best possible allocation of health care resources and to avoid unnecessary expenditures, it is important to understand and quantify the wide-ranging health care costs affecting people suffering from LUTS. We aimed at creating a foundation for exploring the cost of LUTS.
Method: In this systematic literature review, we explored the costs of illness of the LUTS umbrella. We used the online literature review tool Silvi.ai for transparent decision-making and literature management.
Results: A total of 1821 original articles were screened. Forty had explored the cost of illness of a LUTS disease since 2013. The studies were conducted in 18 countries. A number of different study designs were applied, including both retrospective and prospective studies. In total, seven LUTS indications were explored. None of them focused on lifelong LUTS. None of them were conducted in infants or children. Eighty-two percent were conducted in adults and 18% in frail elderly. Most cost of illness studies focused on the cost of hospitalization and use of medicine.
Conclusion: We have created the groundwork for understanding the cost of LUTS illness. To fully understand the cost of illness of lifelong LUTS, the main gap in research is to investigate the cost of LUTS in infants and children.application/pdfhttps://biblio.ugent.be/publication/01HN2KV5MRY13Q84GPHNVKYEXQhttp://hdl.handle.net/1854/LU-01HN2KV5MRY13Q84GPHNVKYEXQhttp://doi.org/10.1002/nau.25389https://biblio.ugent.be/publication/01HN2KV5MRY13Q84GPHNVKYEXQ/file/01HRHEPXXKXFHQZQN1N5EVF5FSengNo license (in copyright)info:eu-repo/semantics/restrictedAccessNEUROUROLOGY AND URODYNAMICSISSN: 0733-2467ISSN: 1520-6777Medicine and Health SciencesUrologyNeurology (clinical)OABnocturialower urinary tract symptomslifelong diseaseshealth economicsenuresiscost of illnessBPHThe cost of lifelong LUTS : a systematic literature reviewjournalArticleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionThe role of renal circadian biorhythms in lifelong LUTS
https://biblio.ugent.be/publication/01HEN1S9TF5NJFWWGP0DW0HCTS
Hervé, FrançoisVande Walle, JohanRaes, AnnHaddad, RebeccaMonaghan, ThomasDrake, Marcus J.Kamperis, KonstantinosDossche, LienZipkin, JacobWeiss, JeffreyVerbakel, IrinaBoukheir, GeorgeEveraert, Karel2024Introduction: This article delves into the intricate relationship between kidney function, diuresis, and lower urinary tract symptoms (LUTS) throughout the transitions of the human lifespan. It explores circadian regulation of urine production, maturation of renal function from birth to adulthood, and effects of aging on kidney function and LUTS. The complex connections between these factors are highlighted, offering insights into potential interventions and personalized management strategies.
Methods: An international panel of seven experts engaged in online discussions, focusing on kidney function, diuresis, and LUTS throughout life. This manuscript summarizes expert insights, literature reviews, and findings presented during a webinar and subsequent discussions.
Results: Renal function undergoes significant maturation from birth to adulthood, with changes in glomerular filtration rate, diuresis, and tubular function. A circadian rhythm in urine production is established during childhood. Adolescents and young adults can experience persistent enuresis due to lifestyle factors, comorbidities, and complex physiological changes. In older adults, age-related alterations in kidney function disrupt the circadian rhythm of diuresis, contributing to nocturnal polyuria and LUTS.
Conclusion: The interplay between kidney function, diuresis, and LUTS is crucial in understanding lifelong urinary health. Bridging the gap between pediatric and adult care is essential to address enuresis in adolescents and young adults effectively. For older adults, recognizing the impact of aging on renal function and fluid balance is vital in managing nocturia. This holistic approach provides a foundation for developing innovative interventions and personalized treatments to enhance quality of life for individuals with LUTS across all stages of life.application/pdfhttps://biblio.ugent.be/publication/01HEN1S9TF5NJFWWGP0DW0HCTShttp://hdl.handle.net/1854/LU-01HEN1S9TF5NJFWWGP0DW0HCTShttp://doi.org/10.1002/nau.25308https://biblio.ugent.be/publication/01HEN1S9TF5NJFWWGP0DW0HCTS/file/01HRKZRKA5WDTDERM7NZS731PDengNo license (in copyright)info:eu-repo/semantics/restrictedAccessNEUROUROLOGY AND URODYNAMICSISSN: 0733-2467ISSN: 1520-6777Medicine and Health SciencesUrologyNeurology (clinical)nocturialower urinary tract symptomslifelongfrailtyenuresisdiuresischildhoodThe role of renal circadian biorhythms in lifelong LUTSjournalArticleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionExploring lifelong overactive bladder : transitions, evidence, and clinical implications : a modified Delphi process
https://biblio.ugent.be/publication/01HQKDQK7V01E82XXMGPVC0P4A
Boukheir, GeorgeVerbakel, IrinaVande Walle, Johan Wyndaele, Michel Sinha, Sanjay Arlandis, SalvadorRaes, Ann Abrams, Paul Wein, AlanHervé, FrançoisEveraert, Karel2024IntroductionOveractive bladder (OAB) is a prevalent urological condition characterized by urinary urgency, with or without urgency urinary incontinence, accompanied by increased daytime frequency and nocturia. However, the current definition of OAB lacks a specified time frame, hindering our understanding of the temporal aspects and transitions that occur within the OAB spectrum.MethodsA modified Delphi study was conducted in three rounds, involving a panel of international experts in functional urology, urogynaecology, geriatrics, transitional medicine, and pediatric urology. The study took place between February 2023 and June 2023 and employed two sequential rounds of online surveys, followed by a final hybrid group discussion session in June 2023.ResultsThe Delphi process resulted in a consensus definition of lifelong OAB as a persistent and continuous condition that may manifest differently from birth and evolve over time, with varying levels of clinical perception. The course of its progression is influenced by transition periods and modifying factors, mainly anatomical, hormonal, and psychosocial/stressors. Three main transition periods were identified: achievement of daytime continence, adulthood to elderly, and transition to frail elderly. The panel also considered the therapeutic and diagnostic implications of lifelong OAB, as well as future research prospects in terms of importance and feasibility.ConclusionsFuture longitudinal research is needed to develop this concept and further identify transitions and temporal dynamics.application/pdfhttps://biblio.ugent.be/publication/01HQKDQK7V01E82XXMGPVC0P4Ahttp://hdl.handle.net/1854/LU-01HQKDQK7V01E82XXMGPVC0P4Ahttp://doi.org/10.1002/nau.25307https://biblio.ugent.be/publication/01HQKDQK7V01E82XXMGPVC0P4A/file/01HQKDRMSD9AGV4SWFE6EAD9M5engNo license (in copyright)info:eu-repo/semantics/restrictedAccessNEUROUROLOGY AND URODYNAMICSISSN: 0733-2467ISSN: 1520-6777Medicine and Health Sciencestransitional caretransition phasesoveractive bladdermodified Delphi processlifelongExploring lifelong overactive bladder : transitions, evidence, and clinical implications : a modified Delphi processjournalArticleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionLifelong LUTS : understanding the bladder's role and implications across transition phases, a comprehensive review
https://biblio.ugent.be/publication/01HQKE21TCBGN3KGHC6VDEGV2A
Boukheir, GeorgeVerbakel, Irina Wyndaele, Michel Monaghan, Thomas F. Sinha, SanjayHolm-Larsen, ToveVan Laecke, Erik Birder, LoriHervé, FrançoisEveraert, Karel2024IntroductionLower urinary tract symptoms (LUTSs) are a diverse array of urinary and pelvic dysfunctions that can emerge from childhood, extend through adulthood, and persist into older age. This narrative review aims to provide a comprehensive perspective on the continuum of LUTS and shed light on the underlying mechanisms and clinical implications that span across the lower urinary tract.MethodsA panel of five experts from Belgium, the Netherlands, India, Denmark, and the United States participated in an intensive research to explore and pinpoint existing insights into the lifelong concept of LUTS, particularly at the pelvic level. The experts reviewed the existing literature and held a webinar to discuss their findings.ResultsChildhood LUTS can persist, resolve, or progress into bladder underactivity, dysfunctional voiding, or pain syndromes. The Lifelong character can be explained by pelvic organ cross-talk facilitated through complex neurological and nonneurological interactions. At the molecular level, the role of vasopressin receptors in the bladder's modulation and their potential relevance to therapeutic strategies for LUTS are explored. Frailty emerges as a parallel concept to lifelong LUTS, with a complex and synergistic relationship. Frailty, not solely an age-related condition, accentuates LUTS severity with insufficient evidence regarding the effectiveness and safety profile of the available therapeutic modalities.ConclusionUnderstanding lifelong LUTSs offers insights into genetic, anatomical, neurological, and molecular mechanisms. Further research could identify predictive biomarkers, elucidate the role of clinically translatable elements in pelvic cross-talk, and uncover molecular signatures for personalized management.application/pdfhttps://biblio.ugent.be/publication/01HQKE21TCBGN3KGHC6VDEGV2Ahttp://hdl.handle.net/1854/LU-01HQKE21TCBGN3KGHC6VDEGV2Ahttp://doi.org/10.1002/nau.25304https://biblio.ugent.be/publication/01HQKE21TCBGN3KGHC6VDEGV2A/file/01HQKE3NGX5R6AH6TB5MJQF4YAengNo license (in copyright)info:eu-repo/semantics/restrictedAccessNEUROUROLOGY AND URODYNAMICSISSN: 0733-2467ISSN: 1520-6777Medicine and Health Sciencesvasopressin receptorspelvic organ cross-talklower urinary tract symptomslifelongfrailtychildhoodLifelong LUTS : understanding the bladder's role and implications across transition phases, a comprehensive reviewjournalArticleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionCould a better understanding of the underlying pathophysiologies lead to more informed treatment choices in patients with lower urinary tract dysfunction due to an acontractile or underactive detrusor? ICI-RS 2023
https://biblio.ugent.be/publication/01HQKF3A1X9GDKWMHQ7C4ZMFK0
Sinha, SanjayEveraert, KarelBoukheir, George Roberts, Neil Solomon, Eskinder Belal, Mohammed Selai, Caroline Perrouin-Verbe, Marie-Aimee Spicchiale, Claudia Fede Wein, Alan Abrams, Paul2024IntroductionThe underlying pathophysiology behind a diagnosis of acontractile or underactive detrusor at invasive urodynamics is very heterogeneous. Lack of etiological classification currently limits the possibility of stratifying therapy.MethodsThis subject was discussed at a think-tank on the subject at the International Consultation on Incontinence-Research Society held in Bristol, June 2023. This manuscript is a result of those deliberations and the subsequent discussions of the think-tank.ResultsThere are challenges in defining abnormalities of detrusor contraction with resultant implications for available evidence. Pathology at any level of the neuromuscular pathway can impair or prevent a detrusor voiding contraction. Attempts have been made to identify clinical markers that might predict an underactive detrusor but strong supporting evidence is lacking. Hence, a holistic approach to phenotyping requires specialized neuro-imaging as well as physiological investigations. Several general measures can help individuals with an abnormal detrusor contraction. The search for a molecule to enhance the detrusor voiding contraction remains elusive but there are promising new candidates. Neuromodulation can help select individuals but data is not well stratified by underlying etiology. Manipulation of central neurotransmitters might offer an alternate therapeutic option.ConclusionsA better understanding of the underlying pathophysiologies behind an abnormality of the detrusor voiding contraction is needed for improving management. Towards this goal, the think-tank proposes a classification of the underactive detrusor that might help in selecting and reporting more well-defined patient cohorts.application/pdfhttps://biblio.ugent.be/publication/01HQKF3A1X9GDKWMHQ7C4ZMFK0http://hdl.handle.net/1854/LU-01HQKF3A1X9GDKWMHQ7C4ZMFK0http://doi.org/10.1002/nau.25329https://biblio.ugent.be/publication/01HQKF3A1X9GDKWMHQ7C4ZMFK0/file/01HQKF4JZECX1D225Z4ZHFYMMHengNo license (in copyright)info:eu-repo/semantics/restrictedAccessNEUROUROLOGY AND URODYNAMICSISSN: 0733-2467ISSN: 1520-6777Medicine and Health Sciencesurodynamicsurination disordersurinary retentionurinary bladderunderactive detrusorunderactivelower urinary tract symptomsacontractile detrusorCould a better understanding of the underlying pathophysiologies lead to more informed treatment choices in patients with lower urinary tract dysfunction due to an acontractile or underactive detrusor? ICI-RS 2023journalArticleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionNocturomics : transition to omics‐driven biomarkers, a systematic review and future prospects
https://biblio.ugent.be/publication/01GRAN8SYZ2JJKPJZJRVRYBY2Y
Gong, SusanBoukheir, GeorgeKabarriti, AbdoKhosla, LakshayGong, FredVan Laecke, ErikWeiss, JeffreyEveraert, KarelHervé, François2023Objective
To systematically review studies that investigated different biomarkers of nocturia, including omics-driven biomarkers or 'Nocturomics'.
Materials and Methods
PubMed((R)), Scopus((R)), and Embase((R)) were searched systematically in May 2022 for research papers on biomarkers in physiological fluids and tissues from patients with nocturia. A distinction was made between biomarkers or candidates discovered by omics techniques, referred to as omics-driven biomarkers, and classical biomarkers, measured by standard laboratory techniques and mostly thought from pathophysiological hypothesis.
Results
A total of 13 studies with 18 881 patients in total were included, eight of which focused on classical biomarkers including: atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), C-reactive protein (CRP), aldosterone, and melatonin. Five were 'Nocturomics', including one that assessed the microbiome and identified 27 faecal and eight urinary bacteria correlated with nocturia; and four studies that identified candidate metabolomic biomarkers, including fatty acid metabolites, serotonin, glycerol, lauric acid, thiaproline, and imidazolelactic acid among others. To date, no biomarker is recommended in clinical practice. Nocturomics are in an embryonic phase of conception but are developing quickly. Although candidate biomarkers are being identified, none of them are yet validated on a large sample, although some preclinical studies have shown a probable role of fatty acid metabolites as a possible biomarker of circadian rhythm and chronotherapy.
Conclusion
Further research is needed to validate biomarkers for nocturia within the framework of a diagnostic and therapeutic precision medicine perspective. We hope this study provides a summary of the current biomarker discoveries associated with nocturia and details future prospects for omics-driven biomarkers.application/pdfhttps://biblio.ugent.be/publication/01GRAN8SYZ2JJKPJZJRVRYBY2Yhttp://hdl.handle.net/1854/LU-01GRAN8SYZ2JJKPJZJRVRYBY2Yhttp://doi.org/10.1111/bju.15975https://biblio.ugent.be/publication/01GRAN8SYZ2JJKPJZJRVRYBY2Y/file/01GRAN9VJQF18FXJX63GTVZTFJengNo license (in copyright)info:eu-repo/semantics/openAccessBJU INTERNATIONALISSN: 1464-4096ISSN: 1464-410XBiology and Life SciencesMedicine and Health SciencesUrologymicrobiomemetabolomicsbiomarkernocturiaNocturomicsNocturomics : transition to omics‐driven biomarkers, a systematic review and future prospectsjournalArticleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionSurgical approaches for pudendal nerve release : a systematic review
https://biblio.ugent.be/publication/01H6YJ8QM9QS0H5CN4TAVA96S0
De Corte, RenéBoukheir, GeorgeMylle, ToonEveraert, KarelHervé, François2023application/pdfhttps://biblio.ugent.be/publication/01H6YJ8QM9QS0H5CN4TAVA96S0http://hdl.handle.net/1854/LU-01H6YJ8QM9QS0H5CN4TAVA96S0http://doi.org/10.1016/j.cont.2023.100929https://biblio.ugent.be/publication/01H6YJ8QM9QS0H5CN4TAVA96S0/file/01H6YJC19BDR9HT02YVKQ4S5QFengCreative Commons Attribution 4.0 International Public License (CC-BY 4.0)info:eu-repo/semantics/openAccessCONTINENCE (AMSTERDAM)ISSN: 2772-9737Medicine and Health SciencesSurgical approaches for pudendal nerve release : a systematic reviewconferenceinfo:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionFrom nocturnal awakenings to nocturnal voiding : the relationship between insomnia and nocturia : a systematic review
https://biblio.ugent.be/publication/01HQKF7XRQYA0B6SVZPDH05B05
Verbakel, IrinaBoukheir, George Bliwise, DonaldVogelaers, DirkHervé, FrançoisWeiss, JeffreyMariman, AnEveraert, Karel2024INTRODUCTION: The aim of this study was to systematically evaluate relevant literature regarding 1) the prevalence of nocturia in patients with insomnia; 2) sleep characteristics of insomniacs with and without nocturia; 3) interventions for the treatment of insomnia and their effect on nocturia.EVIDENCE ACQUISITION: A systematic review of literature was performed through EMBASE, MEDLINE, CLINICALTRIALS.GOV and CENTRAL databases up until November 2022 according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement. From the identified reports, 11 studies were retained, of which 7 were eligible for meta-analysis. Bias assessment was performed using the ROBINS tools as per the Cochrane collaboration guidelines.EVIDENCE SYNTHESIS: A total of 5396 older adults were included in the meta-analysis. The pooled estimate of the OR was 1.958 (95% CI: 1.609-2.384) for nocturia in patients with insomnia based on 7 studies in a random effects model with nonsignificant heterogeneity (I2=50.83%, P=0.06). Wake after sleep onset (WASO) was longer in people with insomnia and nocturia compared to those without and sleep efficiency (SE) declined. Interventions with melatonin, diet and behavioral therapy were beneficial on nocturia frequency in insomniacs. A limiting factor of our analysis was the scarcity of available data, potentially causing an important selection bias. CONCLUSIONS: The overall odds for nocturia in older adults is higher in patients with insomnia than those without and is associated with worse sleep outcomes. Interventions for treating insomnia such as melatonin, behavioral therapy and diet show beneficial results on nocturnal voiding frequency. We advocate for further research in which uniform definitions and questionnaires are used. Routine screening for nocturia in patients with insomnia could be beneficial to maximize sleep quality improvement.application/pdfhttps://biblio.ugent.be/publication/01HQKF7XRQYA0B6SVZPDH05B05http://hdl.handle.net/1854/LU-01HQKF7XRQYA0B6SVZPDH05B05http://doi.org/10.23736/S2724-6051.23.05384-3https://biblio.ugent.be/publication/01HQKF7XRQYA0B6SVZPDH05B05/file/01HQKF8M2KSCEQ7FV3DRK5C8G9engNo license (in copyright)info:eu-repo/semantics/restrictedAccessMINERVA UROLOGY AND NEPHROLOGYISSN: 2724-6051ISSN: 2724-6442Medicine and Health SciencesMeta-analysisSystematic reviewSleep initiation and maintenance disordersSleep wake disordersNocturiaInsomniaFrom nocturnal awakenings to nocturnal voiding : the relationship between insomnia and nocturia : a systematic reviewjournalArticleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionLong term follow up study
https://biblio.ugent.be/publication/01HR224GD1EY5H6DPDFXC59YG3
Vande Walle, JohanEveraert, KarelNorgaard, Jens Peter2011https://biblio.ugent.be/publication/01HR224GD1EY5H6DPDFXC59YG3http://hdl.handle.net/1854/LU-01HR224GD1EY5H6DPDFXC59YG3engJ.P.Norgaardannual report Frederik Paulsen chairMedicine and Health Sciencesnocturia, desmopressinLong term follow up studyconferenceinfo:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersion