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Ghent University Academic Bibliography2000-01-01T00:00+00:001monthly18F-PSMA-11 Versus 68Ga-PSMA-11 positron emission tomography/computed tomography for staging and biochemical recurrence of prostate cancer : a prospective double-blind randomised cross-over trial
https://biblio.ugent.be/publication/01GQFR99PS3HEGSD52YMSX8476
De Man, KathiaVan Laeken, NickSchelfhout, VanessaFendler, Wolfgang P.Lambert, BiekeKersemans, KenPiron, SarahLumen, NicolaasDecaestecker, KarelFonteyne, ValerieDelrue, LoukeDe Vos, FilipOst, Piet2022Background: Fluorine-18 (18F)-labelled prostate-specific membrane antigen (PSMA) offers several advantages over gallium-68 (68Ga) in terms of costs, yield, transport/ distribution, and image resolution.Objective: This trial investigates the new radiotracer 18F-PSMA-11 via a prospective, intraindividual crossover design. The trial was powered for noninferiority of 18F-PSMA-11 over 68Ga-PSMA-11 positron emission tomography (PET)/computed tomography (CT) in terms of the number of positive PET scans. Secondary endpoints were as follows: (1) superiority of 18F-PSMA-11 over 68Ga-PSMA-11 with respect to the number of positive PET scans, the total number of suspicious prostate cancer lesions, and the miPSMA expression score of corresponding lesions; (2) correlation of the PET/CT images with available follow-up data for 18F-PSMA-11 and 68Ga-PSMA-11; and (3) assessment of the interobserver variability.Design, setting, and participants: Prostate cancer patients (primary or biochemical recurrence) were randomised in a double-blind crossover design whereby each patient received both 18F-PSMA-11 and 68Ga-PSMA-11 PET/CT.Outcome measurements and statistical analysis: All scans were reviewed and scored by three independent experienced nuclear physicians following the proposed guideline for the interpretation of PSMA-ligand PET/CT, as described by Eiber et al.application/pdfhttps://biblio.ugent.be/publication/01GQFR99PS3HEGSD52YMSX8476http://hdl.handle.net/1854/LU-01GQFR99PS3HEGSD52YMSX8476http://doi.org/10.1016/j.eururo.2022.05.010https://biblio.ugent.be/publication/01GQFR99PS3HEGSD52YMSX8476/file/01HS8K1T2V050BK7F3FJAJB92CengElsevier BVNo license (in copyright)info:eu-repo/semantics/restrictedAccessEUROPEAN UROLOGYISSN: 0302-2838ISSN: 1873-7560Medicine and Health SciencesUrology68Ga-PSMA-1118F-PSMA-11StagingProstate cancercomputedtomographyPositron emissionBiochemical recurrence18F-PSMA-11 Versus 68Ga-PSMA-11 positron emission tomography/computed tomography for staging and biochemical recurrence of prostate cancer : a prospective double-blind randomised cross-over trialjournalArticleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion