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Ghent University Academic Bibliography2000-01-01T00:00+00:001monthlyThe AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study
https://biblio.ugent.be/publication/01HRSNZA9AB2XB2BKMWREC84G8
Lu, TianqiLahousse, LiesWijnant, SaraChen, JinluanBrusselle, Guy van Hoek, Mandy Zillikens, M. Carola2024BackgroundChronic obstructive pulmonary disease (COPD) and asthma associate with high morbidity and mortality. High levels of advanced glycation end products (AGEs) were found in tissue and plasma of COPD patients but their role in COPD and asthma is unclear.MethodsIn the Rotterdam Study (n = 2577), AGEs (by skin autofluorescence (SAF)), FEV1 and lung diffusing capacity (DLCOc and DLCOc /alveolar volume [VA]) were measured. Associations of SAF with asthma, COPD, GOLD stage, and lung function were analyzed using logistic and linear regression adjusted for covariates, followed by interaction and stratification analyses. sRAGE and EN-RAGE associations with COPD prevalence were analyzed by logistic regression.ResultsSAF associated with COPD prevalence (OR = 1.299 [1.060, 1.591]) but not when adjusted for smoking (OR = 1.106 [0.89, 1.363]). SAF associated with FEV1% predicted (beta=-3.384 [-4.877, -1.892]), DLCOc (beta=-0.212 [-0.327, -0.097]) and GOLD stage (OR = 4.073, p = 0.001, stage 3&4 versus 1). Stratified, the association between SAF and FEV1%predicted was stronger in COPD (beta=-6.362 [-9.055, -3.670]) than non-COPD (beta=-1.712 [-3.306, -0.118]). Association of SAF with DLCOc and DLCOc/VA were confined to COPD (beta=-0.550 [-0.909, -0.191]; beta=-0.065 [-0.117, -0.014] respectively). SAF interacted with former smoking and COPD prevalence for associations with lung function. Lower sRAGE and higher EN-RAGE associated with COPD prevalence (OR = 0.575[0.354, 0.931]; OR = 1.778[1.142, 2.768], respectively).ConclusionsAssociations between SAF, lung function and COPD prevalence were strongly influenced by smoking. SAF associated with COPD severity and its association with lung function was more prominent within COPD. These results fuel further research into interrelations and causality between SAF, smoking and COPD.Take-home messageSkin AGEs associated with prevalence and severity of COPD and lung function in the general population with a stronger effect in COPD, calling for further research into interrelations and causality between SAF, smoking and COPD.application/pdfhttps://biblio.ugent.be/publication/01HRSNZA9AB2XB2BKMWREC84G8http://hdl.handle.net/1854/LU-01HRSNZA9AB2XB2BKMWREC84G8http://doi.org/10.1186/s12931-024-02698-1https://biblio.ugent.be/publication/01HRSNZA9AB2XB2BKMWREC84G8/file/01HRW6RJ3X43C115SGZYZV7WGAengCreative Commons Attribution 4.0 International Public License (CC-BY 4.0)info:eu-repo/semantics/openAccessRESPIRATORY RESEARCHISSN: 1465-993XMedicine and Health SciencesGLYCATION END-PRODUCTSSOLUBLE RECEPTORADVANCED GLYCOXIDATIONENDPRODUCTSASTHMASKINCOMORBIDITIESACCUMULATIONMECHANISMSS100A12Advanced glycation end products (AGEs)Skin autofluorescence (SAF)Chronic obstructive pulmonary disease (COPD)SpirometryLung functionThe AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam studyjournalArticleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion