https://biblio.ugent.be/ Ghent University Academic Bibliography 2000-01-01T00:00+00:00 1 daily https://biblio.ugent.be/publication/01KEY2MCR3E480YBFXHNZHC8V0 Tang, T Pledts, K Moerkerke, Matthijs van der Donck, S Bollen, B Steyaert, J Alaerts, K Ortibus, E Naulaers, G Boets, B 2024 https://biblio.ugent.be/publication/01KEY2MCR3E480YBFXHNZHC8V0 http://hdl.handle.net/1854/LU-01KEY2MCR3E480YBFXHNZHC8V0 http://doi.org/10.3390/brainsci14121168 eng MDPI BRAIN SCIENCES Face Processing in Prematurely Born Individuals-A Systematic Review journalArticle info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://biblio.ugent.be/publication/01KMJHVW5KCNJP0JKD8V5X9DSF Noke, Hannah Mosey, Simon Vere, Kelly 2024 Knowledge exchange (KE) is becoming a strategic imperative for universities globally. Research examining KE has tended to focus on a limited and select group of stakeholders. This paper builds on calls for a wider consideration of KE activities and other contributors to the KE agenda. The technical community is one such group that has received little attention or acknowledgement of their part in KE. We argue that the technical community makes a significant yet overlooked contribution to a broad array of KE activities. Technicians are problem solvers that often undertake work that their academic counterparts could not do-as users and managers of complex equipment to enable innovation. To date the literature provides limited understanding of the technician's role and a lack of conceptualization of the contribution of technicians in KE. Adopting a micro-foundation approach, we present a conceptual framework which draws on the multi-level categories of individuals, processes and structures. We take a broader perspective of KE by including activities such as working with external businesses, enabling access to facilities and providing analysis, and contributing to public engagement and training. By synthesizing contemporary research with recent policy work we reveal the potential contribution of technician's talent, know-how and boundary spanning activities. We conclude with a structured agenda and conceptual framework to help guide future research, showing how investigating the integration of individual, process and structural factors affecting technicians can help reveal new insights into KE capability development at the university level. https://biblio.ugent.be/publication/01KMJHVW5KCNJP0JKD8V5X9DSF http://hdl.handle.net/1854/LU-01KMJHVW5KCNJP0JKD8V5X9DSF http://doi.org/10.1007/s10961-024-10072-y eng SPRINGER JOURNAL OF TECHNOLOGY TRANSFER ISSN: 0892-9912 ISSN: 1573-7047 Technicians Knowledge exchange Micro-foundations L26 TECHNOLOGY-TRANSFER ORGANIZATIONAL ROUTINES ACADEMIC ENTREPRENEURSHIP DYNAMIC CAPABILITIES MULTILEVEL RESEARCH INDUSTRY KNOWLEDGE DEVELOPMENT TEAMS QUADRUPLE HELIX OPEN INNOVATION MICROFOUNDATIONS Understanding university technicians' role in creating knowledge exchange routines and capabilities: a research agenda journalArticle info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://biblio.ugent.be/publication/01HZ1ME9P8QDCKGTVG2FQ0WKGS Depuydt, Emma Criel, Yana De Letter, Miet van Mierlo, Pieter 2024 application/pdf https://biblio.ugent.be/publication/01HZ1ME9P8QDCKGTVG2FQ0WKGS http://hdl.handle.net/1854/LU-01HZ1ME9P8QDCKGTVG2FQ0WKGS https://biblio.ugent.be/publication/01HZ1ME9P8QDCKGTVG2FQ0WKGS/file/01HZ1MMPDGCFW0YMV2YTF1T9PC eng info:eu-repo/semantics/openAccess Neural Traces 2024 Workshop, Abstracts Physics and Astronomy Technology and Engineering Medicine and Health Sciences Investigating the effect of average head models on event-related potential source localization conference info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/publishedVersion https://biblio.ugent.be/publication/01J1QB6JHVMABRBPZ95CW6FPD2 Pérez Baca, Maria del Rocio Palomares, Maria Vanhooydonck, Michiel D'haene, Eva Jacobs, Eva Vantomme, Lies Santos-Simarro, Fernando Lleuger-Pujol, Roser García-Miñáur, Sixto Losantos-García, Itsaso Menten, Björn Sadegheh Haghshenas, Seyyedeh Levy, Michael A. Kerkhof, Jennifer McConkey, Haley Sadikovic, Bekim Dermaut, Bart Bogaert, Elke Vergult, Sarah Callewaert, Bert Consortium, ZFHX4 2024 Neurodevelopmental disorders (NDDs) result from impaired development and functioning of the brain. Here, we identify a novel NDD caused by loss-of-function variation in ZFHX4, encoding a zinc-finger homeodomain transcription factor. In 2011, ZFHX4 haploinsufficiency was suggested as (one of) the underlying mechanism(s) in 8q21.11 microdeletions. Moreover, in 2020, ZFHX4 was reported as a novel NDD candidate gene in a large-scale exome-sequencing study. Through an international collaboration, we gathered data on 47 individuals with protein truncating variants (n=27), (micro)deletions (n=19) or an inversion (n=1) affecting ZFHX4. Loss-of-function of ZFHX4 consistently associates with ID, morphological abnormalities of the central nervous system, short stature, hypotonia and distinctive facial characteristics as supported by artificial intelligence (Face2Gene), and, occasionally, cleft palate and anterior segment dysgenesis. We identified a preliminary mild common DNA methylation profile in leukocyte-derived DNA of patients with truncating variants and with (micro)deletions affecting ZFHX4. Via data-mining and multiple in vitro models we identified ZFHX4 as a nuclear protein and found increasing expression during human brain development and neuronal differentiation. First-generation (F0) zfhx4 crispant zebrafish - (mosaic) mutant for zfhx4 loss-of-function variants - have significantly smaller Meckel’s cartilages and ethmoid plates in comparison with control zebrafish upon Alcian blue staining. To get a better understanding of its role during neurodevelopment, we are currently assessing the interaction partners and downstream targets of ZFHX4 in neural progenitor cells and neural crest cells. In conclusion, ZFHX4 appears to be essential for neural and craniofacial development and ZFHX4 loss-of-function variants are associated with a novel form of syndromic ID. application/vnd.openxmlformats-officedocument.wordprocessingml.document https://biblio.ugent.be/publication/01J1QB6JHVMABRBPZ95CW6FPD2 http://hdl.handle.net/1854/LU-01J1QB6JHVMABRBPZ95CW6FPD2 https://biblio.ugent.be/publication/01J1QB6JHVMABRBPZ95CW6FPD2/file/01J1QCV7C23VZGDPA9J2R5NPG0 eng info:eu-repo/semantics/openAccess Belgian Society for Human Genetics (BeSHG) Annual Symposium 2024 : Single Cells : to care or not to care, Abstracts Medicine and Health Sciences Biology and Life Sciences Loss-of-function of the Zinc Finger Homeobox 4 (ZFHX4) gene causes a novel neurodevelopmental disorder conference info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/publishedVersion https://biblio.ugent.be/publication/01HVRMR53RQ0R4Z1PFARV8B9XF Vandenbussche, Nele Lintermans, Béatrice Merckaert, Tijs Fieuws, Charlotte Gevaert, Kris Claes, Kathleen 2024 With its increasing incidence and dismal prognosis, pancreatic ductal adenocarcinoma (PDAC) is becoming a global oncologic problem. In PDAC patients the presence of circulating tumor cells (CTCs) in the bloodstream is associated with poor overall survival, making CTCs an interesting biomarker. However, detecting CTCs in PDAC patients remains challenging since they are found at very low numbers in blood and consist of various subtypes. The Parsortix® device captures CTCs from blood samples based on cell size and deformability. We evaluated its ability to enrich and capture different subtypes of pancreatic cancer cells. Three pancreatic cancer cell lines, mimicking different CTC subtypes (epithelial, mesenchymal, and intermediate), were stained with a CellTracker Dye and spiked into blood samples from healthy donors. These samples were then processed using the Parsortix® and recovery rates were determined by quantifying the number of cancer cells present after enrichment. The mesenchymal cell line had a lower recovery rate (32.8 ± 10.2%) compared to the epithelial cell line (62.6 ± 18.5%). Using proteomics by data-independent acquisition (DIA)-mass spectrometry (MS), differentially expressed proteins and pathways were identified. The Rho signaling pathway was found downregulated in the mesenchymal cell line compared to the epithelial cell line. This pathway is a key regulator of the cytoskeleton and implicated in cell contractility. Therefore, we are currently investigating if activating the Rho signaling pathway can induce a stiffer cellular phenotype, reduce deformability, and improve Parsortix®-based cell enrichment. Our study highlights the importance of evaluating the recovery rates for different CTC subtypes to develop more effective methods for capturing the heterogeneity of CTCs in liquid biopsies. We hypothesize that introducing an activator of the Rho pathway into PDAC patient blood samples to stiffen CTCs, could enhance recovery rates and facilitate downstream analyses, potentially enhancing the diagnostic and therapeutic utility of CTCs in pancreatic cancer. application/pdf https://biblio.ugent.be/publication/01HVRMR53RQ0R4Z1PFARV8B9XF http://hdl.handle.net/1854/LU-01HVRMR53RQ0R4Z1PFARV8B9XF https://biblio.ugent.be/publication/01HVRMR53RQ0R4Z1PFARV8B9XF/file/01HVRMYZZ37ZXNPPA521QQH1GV eng info:eu-repo/semantics/openAccess Belgian Society for Human Genetics (BeSHG) Annual Symposium 2024 : Single Cells : to care or not to care, Abstracts Medicine and Health Sciences Towards improved Parsortix® efficiency for circulating tumor cell enrichment in pancreatic cancer conference info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/publishedVersion