https://biblio.ugent.be/ Ghent University Academic Bibliography 2000-01-01T00:00+00:00 1 daily https://biblio.ugent.be/publication/01KKBF7BVVZ60PXSB5PCRYF0TZ Vitoratou, Dimitra-Irinna Dimakopoulou, Konstantina Mavrogianni, Christina Karaglani, Eva Argyropoulou, Matzourana Cardon, Greet Usheva, Natalya Iotova, Violeta Tankova, Tsvetalina Giménez-Legarre, Natalia Moreno, Luis A. Toti, Florian Makrilakis, Konstantinos Doracaj, Ditila Imre, Rurik Torzsa, Péter Lindström, Jaana Panagiotakos, Demosthenes Manios, Yannis 2026 Aim: Τo develop a revised version of the FINDRISC tailored to improve the identification of individuals at high risk for type 2 diabetes (T2D) across diverse populations. Methods: The revised-FINDRISC was developed using pooled harmonized baseline data from the multinational Feel4Diabetes (NCT02393872; N = 3526) and DigiCare4You (NCT05648383; N = 2156) studies. Validation utilized data from the 20-year ATTICA cohort study in Greece. Original FINDRISC components were analyzed using Fisher’s Linear Discriminant Analysis followed by supervised stepwise logistic regression to identify significant T2D cross-sectional predictors. The revised-FINDRISC was developed by re-scoring or excluding original items and incorporating new predictors, generating an integer-based score to enhance usability. Results: The revised-FINDRISC significantly improved accuracy in identifying current T2D risk over the original, with an overall AUC of 0.911(95%CI: 0.901,0.922) versus 0.832(0.815,0.846). When stratified by country economic classification, the revised score outperformed the original across all groups: LMICs: 0.881(0.864,0.898) vs. 0.815(0.793,0.837), South European-HICs: 0.891(0.867,0.916) vs. 0.839(0.811,0.869), and North European- HICs: 0.921(0.872,0.971) vs. 0.844(0.742,0.949). A clinical threshold score of 13/24 in the revised-FINDRISC offers optimal sensitivity and specificity for identifying individuals at risk of T2D. Conclusion: Enhanced with demographic, socio-economic, and clinical factors, the revised-FINDRISC potentially represents a substantive advancement in T2D screening, supporting early detection and targeted prevention. application/pdf https://biblio.ugent.be/publication/01KKBF7BVVZ60PXSB5PCRYF0TZ http://hdl.handle.net/1854/LU-01KKBF7BVVZ60PXSB5PCRYF0TZ http://doi.org/10.1016/j.annepidem.2026.110064 https://biblio.ugent.be/publication/01KKBF7BVVZ60PXSB5PCRYF0TZ/file/01KKBFC0HG60P816YF09WQ9CP0 eng info:eu-repo/semantics/openAccess ANNALS OF EPIDEMIOLOGY ISSN: 1047-2797 ISSN: 1873-2585 Medicine and Health Sciences Social Sciences Type 2 diabetes Risk Epidemiology Prevention Screening The revised-FINDRISC : a tool for type 2 diabetes risk screening across diverse populations incorporating sociodemographic indicators journalArticle info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion