https://biblio.ugent.be/ Ghent University Academic Bibliography 2000-01-01T00:00+00:00 1 daily https://biblio.ugent.be/publication/01KXK5A3D1X812XSRCA5JPKS40 Pruss, Kali M. Kao, Clara Byrne, Alexandra E. Chen, Robert Y. Di Luccia, Blanda Karvelyte, Laura Coskun, Reyan Lemieux, Mackenzie Nepal, Keshav Webber, Daniel M. Hibberd, Matthew C. Wang, Yi Liu, Haoxin Rodionov, Dmitry A. Osterman, Andrei L. Colonna, Marco Maueröder, Christian Ravichandran, Kodi Barratt, Michael J. Ahmed, Tahmeed Gordon, Jeffrey I. 2026 Environmental enteric dysfunction (EED), a small intestinal disorder prevalent in undernourished children with stunted growth and their undernourished mothers, is associated with gut mucosal barrier disruption and decreased absorptive capacity. Here we provide preclinical evidence that intergenerational transmission of a perturbed small intestinal microbiota contributes to pathogenesis. One of two bacterial consortia cultured from duodenal aspirates obtained from Bangladeshi children with EED induced local and systemic inflammation in female gnotobiotic mice, resulting in impaired prenatal and postnatal growth in their offspring. Immunologic changes in pups phenocopied features of EED in children, and dam-to-pup transmission of this consortium altered signalling pathways related to intestinal epithelial cell renewal, barrier integrity and immune function. Screening of co-housed mice harbouring the inflammatory or non-inflammatory consortia identified Campylobacter concisus as an inducer of pro-inflammatory cytokine signalling in a host nitric oxide synthase-dependent manner. This preclinical model could facilitate small intestinal microbiota-targeted therapeutics for intergenerational undernutrition. application/pdf https://biblio.ugent.be/publication/01KXK5A3D1X812XSRCA5JPKS40 http://hdl.handle.net/1854/LU-01KXK5A3D1X812XSRCA5JPKS40 http://doi.org/10.1038/s41564-026-02394-4 https://biblio.ugent.be/publication/01KXK5A3D1X812XSRCA5JPKS40/file/01KXK5JDVAKM7AKWPQ1NJ7WZ5C eng info:eu-repo/semantics/openAccess NATURE MICROBIOLOGY ISSN: 2058-5276 Biology and Life Sciences Medicine and Health Sciences Enteropathy produced in mice by intergenerational transmission of small intestinal microbiota from undernourished children journalArticle info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://biblio.ugent.be/publication/1934468 Gámez, Juan Carlos Gibaja, Eva Lucrecia Olivares, Joaquín Palomares, José Manuel Soto, José Manuel Zafra, Amelia Pons, José Enrique Billiet, Christophe De Tré, Guy Pons, Olga De Paermentier, Els Deploige, Jeroen 2011 application/pdf https://biblio.ugent.be/publication/1934468 http://hdl.handle.net/1854/LU-1934468 https://biblio.ugent.be/publication/1934468/file/6738975 spa Universidad de Córdoba info:eu-repo/semantics/openAccess Actas de las II Jornadas Andaluzas de Informatica ISBN: 9788415105374 History and Archaeology Consultas bipolares en bases de datos temporales: aplicación en bases de datos con datos históricos conference info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/publishedVersion https://biblio.ugent.be/publication/2963979 Greco, Salvatore Bouchon-Meunier, Bernadette Coletti, Giulianella Matarazzo, Benedetto Yager, Ronald R Pons, Jose Enrique Billiet, Christophe Pons Capote, Olga De Tré, Guy 2012 application/pdf https://biblio.ugent.be/publication/2963979 http://hdl.handle.net/1854/LU-2963979 http://doi.org/10.1007/978-3-642-31709-5_43 https://biblio.ugent.be/publication/2963979/file/2976736 eng Springer info:eu-repo/semantics/openAccess Communications in Computer and Information Science ISSN: 1865-0929 Technology and Engineering temporal databases fuzzy databases incompleteness information systems A possibilistic valid-time model conference info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/publishedVersion https://biblio.ugent.be/publication/2964010 Greco, Salvatore Bouchon-Meunier, Bernadette Coletti, Giulianella Matarazzo, Benedetto Yager, Ronald R Billiet, Christophe Pons, Jose Enrique Pons Capote, Olga De Tré, Guy 2012 application/pdf https://biblio.ugent.be/publication/2964010 http://hdl.handle.net/1854/LU-2964010 http://doi.org/10.1007/978-3-642-31709-5_42 https://biblio.ugent.be/publication/2964010/file/2976727 eng Springer info:eu-repo/semantics/openAccess Communications in Computer and Information Science ISSN: 1865-0929 Technology and Engineering ill-known intervals valid-time database uncertainty uncertain temporal querying Evaluating possibilistic valid-time queries conference info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/publishedVersion https://biblio.ugent.be/publication/3051015 Pons, Jose Enrique Marin, Nicolas Pons, Olga Billiet, Christophe De Tré, Guy 2012 In real world, it is very common that some objects or concepts have properties with a time-variant or time-related nature. Modelling this kind of objects or concepts in a (relational) database schema is possible, but time-variant and time-related attributes have an impact on the consistency of the entire database and must be appropriately managed. Therefore, temporal database models have been proposed to deal with this problem in the literature. Time can be affected by imprecision, vagueness and / or uncertainty, since existing time measuring devices are inherently imperfect. Additionally, human beings manage time using temporal indications and temporal notions, which may also be imprecise. However, the imperfection in human-used temporal indications is supported by human interpretation, whereas information systems need appropriate support in order to accomplish this task. Several proposals for dealing with such imperfections when modelling temporal data exist. Some of these proposals transform the temporal data into a compact representation but there is not a formal model for managing and handling uncertainty regarding temporal information. In this work we present a novel model to deal with imprecision in valid-time databases together with the definition and implementation of the data manipulation language, DML. application/pdf https://biblio.ugent.be/publication/3051015 http://hdl.handle.net/1854/LU-3051015 http://doi.org/10.1080/18756891.2012.747662 https://biblio.ugent.be/publication/3051015/file/3051020 https://biblio.ugent.be/publication/3051015/file/3051020 eng info:eu-repo/semantics/restrictedAccess INTERNATIONAL JOURNAL OF COMPUTATIONAL INTELLIGENCE SYSTEMS ISSN: 1875-6883 Technology and Engineering INTERVALS TEMPORAL KNOWLEDGE DATABASES fuzzy temporal database A relational model for the possibilistic valid-time approach journalArticle info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://biblio.ugent.be/publication/3069078 De Tré, Guy Bronselaer, Antoon Billiet, Christophe Qiang, Yi Van de Weghe, Nico De Maeyer, Philippe Pons, José Enrique Pons, Olga 2012 application/pdf https://biblio.ugent.be/publication/3069078 http://hdl.handle.net/1854/LU-3069078 https://biblio.ugent.be/publication/3069078/file/6782038 https://biblio.ugent.be/publication/3069078/file/6782038 eng info:eu-repo/semantics/restrictedAccess The 2nd world conference on soft computing : proceedings ISBN: 9789952452372 Science General Visualising and handling uncertain time intervals in a two-dimensional triangular space conference info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/publishedVersion https://biblio.ugent.be/publication/4145801 Legind Larsen, Henrik Martin-Bautista, Maria J Amparo Vila, María Andreasen, Troels Christiansen, Henning Billiet, Christophe Pons Frías, José Enrique Pons Capote, Olga De Tré, Guy 2013 Databases model parts of reality by containing data representing properties of real-world objects or concepts. Often, some of these properties are time-related. Thus, databases often contain data representing time-related information. However, as they may be produced by humans, such data or information may contain imperfections like uncertainties. An important purpose of databases is to allow their data to be queried, to allow access to the information these data represent. Users may do this using queries, in which they describe their preferences concerning the data they are (not) interested in. Because users may have both positive and negative such preferences, they may want to query databases in a bipolar way. Such preferences may also have a temporal nature, but, traditionally, temporal query conditions are handled specifically. In this paper, a novel technique is presented to query a valid-time relation containing uncertain valid-time data in a bipolar way, which allows the query to have a single bipolar temporal query condition. application/pdf https://biblio.ugent.be/publication/4145801 http://hdl.handle.net/1854/LU-4145801 http://doi.org/10.1007/978-3-642-40769-7_35 https://biblio.ugent.be/publication/4145801/file/4147888 eng Springer info:eu-repo/semantics/openAccess LECTURE NOTES IN COMPUTER SCIENCE ISSN: 0302-9743 ISBN: 9783642407680 Technology and Engineering Uncertainty Possibility Theory Temporal Databases Valid Time Ill-known Intervals Valid-time Relation Bipolar Querying Bipolar querying of valid-time intervals subject to uncertainty conference info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/publishedVersion https://biblio.ugent.be/publication/4162125 Pivert, Olivier Zadrozny, Slawomir Pons Frías, José Enrique Billiet, Christophe Pons, Olga De Tré, Guy 2013 In reality, some objects or concepts have properties with a time-variant or time-related nature. Modelling these kinds of objects or concepts in a (relational) database schema is possible, but time-variant and time-related attributes have an impact on the consistency of the entire database. Therefore, temporal database models have been proposed to deal with this. Time itself can be at the source of imprecision, vagueness and uncertainty, since existing time measuring devices are inherently imperfect. Accordingly, human beings manage time using temporal indications and temporal notions, which may contain imprecision, vagueness and uncertainty. However, the imperfection in human-used temporal indications is supported by human interpretation, whereas information systems need extraordinary support for this. Several proposals for dealing with such imperfections when modelling temporal aspects exist. Some of these proposals consider the basis of the system to be the conversion of the specificity of temporal notions between used temporal expressions. Other proposals consider the temporal indications in the used temporal expressions to be the source of imperfection. In this chapter, an overview is given, concerning the basic concepts and issues related to the modelling of time as such or in (relational) database models and the imperfections that may arise during or as a result of this modelling. Next to this, a novel and currently researched technique for handling some of these imperfections is presented. application/pdf https://biblio.ugent.be/publication/4162125 http://hdl.handle.net/1854/LU-4162125 http://doi.org/10.1007/978-3-319-00954-4 https://biblio.ugent.be/publication/4162125/file/4162139 eng Springer info:eu-repo/semantics/openAccess Flexible approaches in data, information and knowledge management ISSN: 1860-949X ISBN: 9783319009537 Technology and Engineering Aspects of dealing with imperfect data in temporal databases bookChapter info:eu-repo/semantics/bookPart info:eu-repo/semantics/publishedVersion https://biblio.ugent.be/publication/4162152 Atanassov, Krassimir Homenda, Wladyslaw Hryniewicz, Olgierd Kacprzyk, Janusz Krawczak, Maciej Nahorski, Zbigniew Szmidt, Eulalia Zadrozny, Slawomir Billiet, Christophe Pons Frías, José Enrique Pons, Olga De Tré, Guy 2013 A database represents part of reality by containing data representing properties of real objects or concepts. To many real-world concepts or objects, time is an essential aspect and thus it should often be (implicitly) represented by databases, making these temporal databases. However, like other data, the time-related data in such databases may also contain imperfections such as uncertainties. One of the main purposes of a database is to allow the retrieval of information or knowledge deduced from its data, which is often done by querying the database. Because users may have both positive and negative preferences, they may want to query a database in a bipolar way. Moreover, their demands may have some temporal aspects. In this paper, a novel technique is presented, to query a valid-time relation containing uncertain valid-time data in a heterogeneously bipolar way, allowing every elementary query constraint a specific temporal constraint. application/pdf https://biblio.ugent.be/publication/4162152 http://hdl.handle.net/1854/LU-4162152 https://biblio.ugent.be/publication/4162152/file/4162157 eng SRI PAS/IBS PAN info:eu-repo/semantics/openAccess New trends in fuzzy sets, intuitionistic fuzzy sets, generalized nets and related topics volume II : applications ISBN: 9788389475473 Technology and Engineering Temporal Databases Bipolar Querying Ill-known Time Intervals Valid-time Relation Uncertainty Bipolarity in the querying of temporal databases bookChapter info:eu-repo/semantics/bookPart info:eu-repo/semantics/publishedVersion https://biblio.ugent.be/publication/5715044 Angelov, P Atanassov, KT Doukovska, L Hadjiski, M Jotsov, V Kacprzyk, J Kasabov, N Sotirov, S Szmidt, E Zadrozny, S Billiet, Christophe De Tré, Guy 2015 Database systems contain data representing properties of real-life objects or concepts. Many of these data represent time indications and such time indications are often subject to imperfections. Although several existing proposals deal with the modeling of uncertainty or vagueness in time indications in database systems, only a few of them summarily examine the interpretation and semantics of such imperfections. The work presented in this paper starts at a more thorough examination of the semantics and modeling of uncertainty or vagueness in time intervals in database systems and presents methods to model combinations of uncertainty and vagueness in time intervals in database systems, based on examinations of their requisite interpretations. application/pdf https://biblio.ugent.be/publication/5715044 http://hdl.handle.net/1854/LU-5715044 http://doi.org/10.1007/978-3-319-11313-5_32 https://biblio.ugent.be/publication/5715044/file/5715234 eng Springer info:eu-repo/semantics/openAccess INTELLIGENT SYSTEMS'2014, VOL 1: MATHEMATICAL FOUNDATIONS, THEORY, ANALYSES ISSN: 2194-5357 ISSN: 2194-5365 ISBN: 9783319113128 ISBN: 9783319113135 Technology and Engineering MODEL SETS DATABASE VALID-TIME FUZZY INTERVALS Combining uncertainty and vagueness in time intervals conference info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/publishedVersion